Longitudinal Academic Performance in Children with a History of Neonatal Abstinence Syndrome

有新生儿戒断综合症病史的儿童的纵向学业表现

• 批准号: 10608149
• 负责人: Tammy E Corr
• 金额: $ 19.94万
• 依托单位: PENNSYLVANIA STATE UNIV HERSHEY MED CTR
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-05-01 至 2027-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10608149
• 关键词: 3 year old; Academic Medical Centers; Academic achievement; Accounting; Achievement; Adult; Affect; Age; Biological; Biometry; Caregivers; Caring; Child; Child Welfare; Childhood; Clinical; Clinical Research; Communities; Community Health; Complement; Complex; Conduct Clinical Trials; Crime; Data; Databases; Deterioration; Development; Developmental Delay Disorders; Diagnosis; Disparity; Drug Exposure; Early Intervention; Education; Environment; Epidemiology; Evaluation; Family; Foundations; Future; Generations; Goals; Grant; Health; Health Care Rationing; Illicit Drugs; Incidence; Individual; Infant; Influentials; Information Systems; Intervention; Intervention Studies; Interview; K-Series Research Career Programs; Learning; Link; Measures; Mentorship; Methodology; Methods; Mothers; Neonatal; Neonatal Abstinence Syndrome; Newborn Infant; Nursery Schools; Opioid; Outcome; Parents; Pennsylvania; Performance; Physicians; Policies; Pregnant Women; Problem behavior; Productivity; Public Health; Race; Recording of previous events; Reporting; Research; Research Design; Research Methodology; Research Personnel; Resolution; Resources; Risk; School-Age Population; Schools; Scientist; Services; Severities; Social Environment; Social Welfare; Socioeconomic Factors; Special Education; Symptoms; Syndrome; Testing; Time; Toddler; Training; Translating; United States National Institutes of Health; United States Substance Abuse and Mental Health Services Administration; Withdrawal; achievement test; career development; clinical practice; cost; data warehouse; design; drug exposure in utero; early childhood; effective intervention; experience; health economics; improved; improved outcome; in utero; inattention; neonate; neurodevelopment; opioid epidemic; patient oriented; postnatal; research and development; sex; success

Project Summary/Abstract The objectives of this project are to more thoroughly understand the relationship between neonatal abstinence syndrome (NAS) and longitudinal academic performance. NAS is a withdrawal condition due to in utero drug exposure, most commonly opioids. The syndrome affects more than 32,000 newborns annually in the U.S., and its incidence continues to rise. Researchers report poorer development in toddler and preschool years, higher rates of inattention and behavioral problems, and worse and deteriorating school performance in children with a history of NAS, indicating the effects of NAS may last well beyond the newborn period. However, these existing studies do not sufficiently account for the complex interaction of biologic, health, and socioenvironmental influences on childhood development. Thus, the relationship between NAS and long-term neurodevelopment and academic achievement remains largely unknown. As school achievement is directly associated with adult productivity and negatively correlated with participation in crime, a better understanding of NAS and academic performance is urgently needed to optimize outcomes across a lifetime. This proposal aims to assess the independent relationship between NAS, NAS severity, NAS treatment, in utero drug exposure and longitudinal academic performance after controlling for relevant biologic, health, and socioenvironmental variables; to explore the moderator effects of early community and school resource support on NAS; and to learn how families’ school experiences may explain childhood academic performance. The former aims will be accomplished using an inclusive, uniquely-integrated South Carolinian data warehouse. With this data system, a child with a diagnosis of NAS can be linked with his/her mother, and the dyad can be followed so that a broad range of childhood outcomes can be examined in the context of relevant, influential factors. In addition, through qualitative interviews with parents and guardians of children with a history of NAS followed at a Pennsylvania academic medical center, the project will 1) explore if and how caregivers’ experiences regarding early community and school resource support are related to childhood academic performance and 2) analyze themes that emerge around barriers and facilitators of academic achievement in children with NAS. Under this career development award, the applicant receives training in methodology of data-driven, public health studies and patient-oriented, clinical research design; epidemiology, mixed methodologies, community health, and applying public health principles to clinical practice; and moving research to policy. Successful completion of the project will not only provide data to serve as the foundation for future studies evaluating NAS outcomes and treatment, but, in addition to her training and mentorship plan, will prepare the applicant to become an independent physician-scientist able to conduct clinical trials aimed at improving outcomes of children affected by NAS.

项目摘要/摘要 这个项目的目标是更彻底地了解新生儿和 戒断综合症(NAS)与纵向学习成绩的关系。由于In，NAS是退出条件 宫内药物暴露，最常见的是阿片类药物。这种综合征每年影响超过32,000名新生儿 在美国，而且它的发病率继续上升。研究人员报告幼儿和学龄前儿童发育较差 年，注意力不集中和行为问题的比率更高，学校表现更差和恶化 有NAS病史的儿童，表明NAS的影响可能会持续到新生儿期以后。 然而，这些现有的研究没有充分考虑到生物、健康和 社会环境对儿童发展的影响。因此，NAS与长期 神经发育和学术成就在很大程度上仍然不为人知。因为学校的成绩直接 与成人生产力相关，与参与犯罪负相关，更好地理解 我们迫切需要NAS和学习成绩的综合评价来优化一生的成果。 本提案旨在评估NAS、NAS严重程度、NAS治疗、 子宫药物暴露和纵向学术表现在控制了相关的生物、健康和 社会环境变量；探索早期社区和学校资源的调节作用 对NAS的支持；以及了解家庭的在校经历如何解释儿童的学习表现。 前一个目标将使用包容的、唯一整合的南卡罗来纳州数据来实现 仓库。有了这个数据系统，被诊断为NAS的儿童可以与他/她的母亲联系起来， 可以跟踪DYAD，以便可以在相关的、 影响因素。此外，通过对患有艾滋病儿童的父母和监护人进行定性采访， 在宾夕法尼亚州的一个学术医疗中心，该项目将跟踪NAS的历史，探索是否以及如何 照顾者在早期社区和学校资源支持方面的经验与童年有关 学术表现和2)分析围绕学术障碍和促进者出现的主题 NAS儿童的成就。 根据这一职业发展奖，申请人接受数据驱动的公共方法论方面的培训 健康研究和以患者为中心的临床研究设计；流行病学、混合方法、社区 将公共卫生原则应用于临床实践；将研究转化为政策。成功 该项目的完成不仅将提供数据，作为未来评估NAS的研究的基础 结果和治疗，但除了她的培训和指导计划外，还将使申请者准备 成为一名独立的内科科学家，能够进行旨在改善治疗结果的临床试验 受NAS影响的儿童。