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Multimodal Musical Stimulation for Healthy Neurocognitive Aging

多模式音乐刺激促进健康的神经认知衰老

基本信息

批准号：
10351738
负责人：
Edward W Large
金额：
$ 19.74万
依托单位：
NORTHEASTERN UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-03-15 至 2024-02-29
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10351738
关键词：
Acoustic Stimulation Acoustics Address Affect Aging Alzheimer&apos s disease model Alzheimer’s disease biomarker Amyloid beta-Protein Animal Model Attention Auditory Behavior Behavioral Biological Models Brain Cognition Cognitive Cognitive aging Collaborations Comprehension Computer software Coupled Coupling Dementia Development Devices Double-Blind Method Elderly Electroencephalography Feasibility Studies Frequencies Gene Expression Geriatrics Health Human Impaired cognition Individual Knowledge Light Link Longevity Memory Methods Microglia Modeling Motor Music Neural Network Simulation Neurocognitive Neurologic Neurology Neurons Neurosciences Nonlinear Dynamics Pattern Perception Performance Periodicity Photic Stimulation Placebo Control Population Process Randomized Randomized Controlled Trials Research Personnel Role Scalp structure Science Sensory Short-Term Memory Signal Transduction Synapses System Testing Time Transcranial magnetic stimulation Visual Work cell type experience improved indexing innovation mouse model multimodality neurophysiology neuroregulation noninvasive brain stimulation optogenetics relating to nervous system signal processing tool young adult

项目摘要

Abstract Music that we encounter every day contains amplitude and frequency modulations, rapid changes in acoustic signals that convey meaningful information to the listener. The human brain’s ability to receive and interpret meaning from these signals is implemented by networks of neural oscillations: firing patterns of groups of neurons that track the music with rhythmic activity. Neural oscillations in different frequency bands subserve attention and memory, as well as perception and comprehension; they develop over the lifespan and are reduced in aging, especially in dementia. Being able to understand and causally control neural oscillations will have crucial implications for healthy neurocognitive aging. Since music naturally stimulates the brain with its rhythmic content over time, we hypothesize that music can be used as a sustainable, naturalistic form of brain stimulation to induce oscillatory in neuronal populations. Furthermore, we hypothesize that by inserting gamma-band energy as sensory stimulation during music listening, we can increase gamma-band activity in the brain in a way that is frequency-tuned to the brain’s intrinsic network dynamics, thus replacing the decreased neural oscillations that are reduced in aging, and improving memory and cognition in older adults. We hypothesize that gamma-band modulations inserted in lights, when coupled with music listening, can improve memory in older adults by frequency-tuning to intrinsic individual brain network dynamics. Here we propose the first randomized, double-blind, placebo-controlled feasibility study, to test the effects of music-coupled gamma-band stimulation on EEG and behavioral indices of working memory in older adults. Results will test the causal role of oscillatory mechanisms of the brain on cognition. If successful, this trial will lay the groundwork to the first musical, neurophysiologically targeted, brain-stimulation device for reversing cognitive decline in aging.

摘要