Multimodal Musical Stimulation for Healthy Neurocognitive Aging

多模式音乐刺激促进健康的神经认知衰老

• 批准号: 10351738
• 负责人: Edward W Large
• 金额: $ 19.74万
• 依托单位: NORTHEASTERN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-03-15 至 2024-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10351738
• 关键词: Acoustic Stimulation; Acoustics; Address; Affect; Aging; Alzheimer' s disease model; Alzheimer’s disease biomarker; Amyloid beta-Protein; Animal Model; Attention; Auditory; Behavior; Behavioral; Biological Models; Brain; Cognition; Cognitive; Cognitive aging; Collaborations; Comprehension; Computer software; Coupled; Coupling; Dementia; Development; Devices; Double-Blind Method; Elderly; Electroencephalography; Feasibility Studies; Frequencies; Gene Expression; Geriatrics; Health; Human; Impaired cognition; Individual; Knowledge; Light; Link; Longevity; Memory; Methods; Microglia; Modeling; Motor; Music; Neural Network Simulation; Neurocognitive; Neurologic; Neurology; Neurons; Neurosciences; Nonlinear Dynamics; Pattern; Perception; Performance; Periodicity; Photic Stimulation; Placebo Control; Population; Process; Randomized; Randomized Controlled Trials; Research Personnel; Role; Scalp structure; Science; Sensory; Short-Term Memory; Signal Transduction; Synapses; System; Testing; Time; Transcranial magnetic stimulation; Visual; Work; cell type; experience; improved; indexing; innovation; mouse model; multimodality; neurophysiology; neuroregulation; noninvasive brain stimulation; optogenetics; relating to nervous system; signal processing; tool; young adult

Abstract Music that we encounter every day contains amplitude and frequency modulations, rapid changes in acoustic signals that convey meaningful information to the listener. The human brain’s ability to receive and interpret meaning from these signals is implemented by networks of neural oscillations: firing patterns of groups of neurons that track the music with rhythmic activity. Neural oscillations in different frequency bands subserve attention and memory, as well as perception and comprehension; they develop over the lifespan and are reduced in aging, especially in dementia. Being able to understand and causally control neural oscillations will have crucial implications for healthy neurocognitive aging. Since music naturally stimulates the brain with its rhythmic content over time, we hypothesize that music can be used as a sustainable, naturalistic form of brain stimulation to induce oscillatory in neuronal populations. Furthermore, we hypothesize that by inserting gamma-band energy as sensory stimulation during music listening, we can increase gamma-band activity in the brain in a way that is frequency-tuned to the brain’s intrinsic network dynamics, thus replacing the decreased neural oscillations that are reduced in aging, and improving memory and cognition in older adults. We hypothesize that gamma-band modulations inserted in lights, when coupled with music listening, can improve memory in older adults by frequency-tuning to intrinsic individual brain network dynamics. Here we propose the first randomized, double-blind, placebo-controlled feasibility study, to test the effects of music-coupled gamma-band stimulation on EEG and behavioral indices of working memory in older adults. Results will test the causal role of oscillatory mechanisms of the brain on cognition. If successful, this trial will lay the groundwork to the first musical, neurophysiologically targeted, brain-stimulation device for reversing cognitive decline in aging.

抽象的 我们每天遇到的音乐都包含振幅和频率调制， 声音信号的快速变化向听众传达有意义的信息。 人脑接收和解释这些信号含义的能力是 由神经振荡网络实现：神经元组的放电模式 通过有节奏的活动来追踪音乐。不同频段的神经振荡 促进注意力和记忆力，以及感知和理解力；他们 在整个生命周期中都会发展，并随着衰老而减少，尤其是在痴呆症中。能够 理解和因果控制神经振荡将对 健康的神经认知衰老。由于音乐自然会刺激大脑 随着时间的推移，有节奏的内容，我们假设音乐可以被用作可持续的、 大脑刺激的自然形式，可引起神经元群的振荡。 此外，我们假设通过插入伽马能带能量作为感觉 听音乐时的刺激，我们可以增加大脑中的伽马带活动 一种根据大脑内在网络动态进行频率调整的方法，从而取代 神经振荡减少，随着年龄的增长而减少，并改善记忆力和 老年人的认知能力。我们假设伽玛波段调制插入 灯光与音乐相结合可以通过以下方式改善老年人的记忆力： 频率调谐到内在的个体大脑网络动态。在这里我们建议 第一项随机、双盲、安慰剂对照的可行性研究，以测试效果 音乐耦合伽玛波段刺激对脑电图和工作行为指数的影响 老年人的记忆力。结果将测试振荡机制的因果作用 大脑的认知。如果成功的话，这次试验将为第一部音乐剧奠定基础 以神经生理学为目标的大脑刺激装置，用于逆转认知能力下降 老化。