Zebrafish Inner Ear Regeneration
斑马鱼内耳再生
基本信息
- 批准号:10349933
- 负责人:
- 金额:$ 22.32万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-01-01 至 2023-12-31
- 项目状态:已结题
- 来源:
- 关键词:Aminoglycoside AntibioticsAminoglycoside resistanceAnimalsBirdsBody SurfaceCapsaicinCell physiologyClustered Regularly Interspaced Short Palindromic RepeatsCommunitiesConsumptionDevelopmentEarExposure toFishesFluorescent in Situ HybridizationFutureGene ExpressionGene TargetingGeneticGenetic ModelsGoalsGrowthHairHair CellsHearing problemHourHumanInner Hair CellsLabyrinthLocationMammalsMapsMediatingMethodsModelingMolecular AnalysisNatural regenerationNuclearOrganPathway interactionsPharmaceutical PreparationsPredispositionProcessPropertyProteinsReagentRecoveryRegenerative capacityRegenerative researchReproducibilityResolutionSensory HairSeriesStudy modelsSupporting CellSystemTestingTimeToxic effectTransgenic OrganismsWorkZebrafishcell typeequilibration disorderexperimental studyfunctional restorationgenetic analysishair cell regenerationin vivoin vivo imaginglateral linemethod developmentpostnatal developmentrapid techniqueregenerativerestorationsingle cell analysissingle-cell RNA sequencingtooltranscriptome sequencingtranslational approachtranslational therapeuticswater flow
项目摘要
PROJECT SUMMARY
Mechanosensory hair cell loss in the inner ear is a leading cause of hearing and balance disorders.
Unfortunately hair cell loss is permanent as humans have little or no capacity for regenerative recovery of hair
cells. Although there has been recent progress in the restoration of hair cells in mammals by promoting
expression of genes and pathways used during development, functional restoration is largely incomplete and
within a limited window of postnatal development. By contrast non-mammalian species from fish to birds
readily replace hair cells from surrounding supporting cell precursors. Critical to understanding hair cell
regeneration is the identification of the subpopulations of supporting cells that sustain regeneration. The
zebrafish is well established as a system to study regeneration with the advantages of advanced genetics and
in vivo imaging of living animals. Considerable progress has been made on understanding regeneration in the
lateral line system, the series of mechanosensory hair cells on the surface of the body used detect water flow
that share many properties with hair cells of the inner ear. By contrast there have been very few studies of hair
cell regeneration in the zebrafish inner ear, mainly because there has been no reliable method for causing
rapid and reproducible damage. In addition little is known about supporting cell types in the zebrafish inner
ear. Overcoming both of these obstacles would establish the zebrafish inner ear as a new model for hair cell
regeneration. We propose to develop tools for rapid, reproducible damage and regeneration in the zebrafish
inner ear. We also propose to identify inner ear supporting cell types, including potential hair cell precursors.
Successful completion of these aims will provide important tools for the community to begin new studies in
zebrafish inner ear regeneration.
项目总结
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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David W Raible其他文献
David W Raible的其他文献
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{{ truncateString('David W Raible', 18)}}的其他基金
Mitochondrial function and dysfunction in hair cells
毛细胞的线粒体功能和功能障碍
- 批准号:
9215463 - 财政年份:2016
- 资助金额:
$ 22.32万 - 项目类别:
Mitochondrial function and dysfunction in hair cells
毛细胞的线粒体功能和功能障碍
- 批准号:
10056217 - 财政年份:2016
- 资助金额:
$ 22.32万 - 项目类别:
CRISPR Screen for Hair Cell Development and Regeneration Regulators
毛细胞发育和再生调节因子的 CRISPR 筛选
- 批准号:
9186821 - 财政年份:2016
- 资助金额:
$ 22.32万 - 项目类别:
2013 Neural Crest & Cranial Placodes Gordon Research Conference
2013 神经嵴
- 批准号:
8594021 - 财政年份:2013
- 资助金额:
$ 22.32万 - 项目类别:
Drug Discovery for the Prevention of Hearing Loss
预防听力损失的药物发现
- 批准号:
8517843 - 财政年份:2011
- 资助金额:
$ 22.32万 - 项目类别:
Drug Discovery for the Prevention of Hearing Loss
预防听力损失的药物发现
- 批准号:
8877478 - 财政年份:2011
- 资助金额:
$ 22.32万 - 项目类别:
Drug Discovery for the Prevention of Hearing Loss
预防听力损失的药物发现
- 批准号:
8128231 - 财政年份:2011
- 资助金额:
$ 22.32万 - 项目类别:
Drug Discovery for the Prevention of Hearing Loss
预防听力损失的药物发现
- 批准号:
8287577 - 财政年份:2011
- 资助金额:
$ 22.32万 - 项目类别:
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