2013 Neural Crest & Cranial Placodes Gordon Research Conference

描述(由申请人提供)：神经脊和颅骨胎盘细胞对胚胎结构有广泛的贡献，对了解许多先天性疾病具有重要意义。神经脊来源的细胞作为干细胞一直存活到成年，他们的研究为干细胞生物学提供了广泛的见解。它们是胚胎发生期间高度迁移的细胞群体，了解它们的运动性调节也可能有助于揭示转移性肿瘤细胞的错误侵袭性。对神经脊和安慰剂的研究已经有了丰富的历史，并且一直在不断地发展，所以令人惊讶的是，到目前为止还没有专门讨论这一主题的常设会议。这次会议将促进我们对两个在发育、进化和临床上重要的细胞群体的理解的分享和进步。会议的最终目标将是加速不同模型系统之间的信息交换，并促进技术创新和基因组规模对支配神经脊和颅骨安慰剂形成和随后分化的机制的理解。

DESCRIPTION (provided by applicant): Neural crest and cranial placodal cells make extensive contributions to embryonic structures, and are of central importance to understanding many congenital disorders. Neural crest-derived cells persist as stem cells into adulthood, and their study has provided broad insights into stem cell biology. They are a highly migratory population of cells during embryogenesis, understanding the regulation of their motility may also shed light on the misregulated invasiveness of metastatic tumor cells. The study of the neural crest and placodes has a rich history, and has been constantly growing, so it is somewhat surprising that to date there has not been a standing meeting dedicated to this topic. This conference will facilitate shared insights and fuel advances in our understanding of two developmentally, evolutionarily, and clinically important populations of cells. The ultimate goal o the conference will be to accelerate the exchange of information across different model systems, and to promote technological innovations and a genome scale understanding of the mechanisms that govern the formation, and subsequent differentiation, of the neural crest and cranial placodes.