Discovery and Characterization of Novel Sepsis Proteome Biomarkers
新型脓毒症蛋白质组生物标志物的发现和表征
基本信息
- 批准号:10364288
- 负责人:
- 金额:$ 55.43万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-09-10 至 2025-08-31
- 项目状态:未结题
- 来源:
- 关键词:AccountingAcuteAddressBacteremiaBacteriaBioinformaticsBiologicalBiological MarkersBlood TestsBlood specimenCardiovascular DiseasesCause of DeathCessation of lifeClinicalComplexCoupledDataData SetDevelopmentDiabetes MellitusDiagnosisDiagnosticDiseaseDoseEarly DiagnosisEarly treatmentEscherichia coliEvaluationFoundationsFunctional disorderFutureGoalsHospital CostsHumanImmune responseImmune systemImmunoassayInfectionInfrastructureLifeMalignant NeoplasmsMass Spectrum AnalysisMethodsMissionModelingMonitorNational Institute of General Medical SciencesOklahomaOrganPapioPathologistPatientsPlasmaPositioning AttributePrognosisProteomeProteomicsPublic HealthRaceResearchResourcesSamplingScientistSepsisSeptic ShockSepticemiaSourceSpecialistStandardizationStaphylococcus aureusSyndromeTestingTherapeuticTimeTissue SampleTranslatingValidationbasebiomarker developmentbiomarker discoverybiomarker panelbiomarker signaturebiomarker validationcandidate markerclinical developmentcohortcomorbiditydifferential expressiondrug developmentearly detection biomarkersexperienceexperimental studyimproved outcomeinstrumentationmedical attentionmicrobialmultidisciplinarynonhuman primatenovelnovel markernovel therapeuticspathogenpatient stratificationperformance testspersonalized medicinepredictive markerprotein biomarkersproteomic signatureresearch clinical testingseptic patientsspecific biomarkersstatisticstargeted treatmenttooltreatment strategyvalidation studies
项目摘要
ABSTRACT
This project will use mass spectrometry-based proteomics for biomarker discovery and validation and will
perform early evaluation of strong candidate biomarkers and biomarker signatures that might form the foundation
for new clinical blood tests. These biomarkers can be used as diagnostic tools for early detection of sepsis and/or
facilitate the clinical development of sepsis therapeutics.
Objectives: The focus of this application is on the identification and initial biological, analytical and clinical
evaluation of biomarkers and biomarker signatures for sepsis that will be ready for definitive analytical and clinical
validation.
Central hypothesis: Discovery proteomics using blood samples from well-standardized non-human primate
sepsis models followed by validation in clinical samples has the potential to reveal new biomarker and biomarker
panels for early detection, prognosis and therapy monitoring of sepsis patients.
Rationale: Sepsis is a complex, heterogeneous disease that frequently is complicated with comorbidities (e.g.,
cancer, diabetes, cardiovascular disease) that can alter the host responses to pathogens, thus making it difficult
to determine the spectrum of sepsis-specific biomarkers by discovery proteomics in clinical plasma samples. We
propose to use unbiased proteomics, coupled with robust bioinformatics to discover novel predictive biomarkers.
We are in a unique position to achieve these goals, having access to well-characterized plasma samples from
historical time-course experiments using baboon models of Gram-negative or Gram-positive bacteremia –
coupled with access to a NIGMS national proteomics resource equipped with world-class instrumentation and
expertise. Further, quantitative proteomics and immunoassays will be used for qualification and validation of the
novel biomarkers in human plasma from sepsis patients.
Specific Aim 1: Identification and organ mapping of early stage biomarkers during the time course of
experimental sepsis in baboons.
Specific Aim 2: Validation and performance testing of biomarker candidates in clinical samples.
Impact: Our short-term goals are to identify biomarkers and biomarker signatures for sepsis in baboons and
perform the initial biological, analytical and clinical evaluation in humans using carefully standardized samples
and datasets. The long-term goal of our project is to deliver novel candidate biomarkers that are ready for
definitive analytical and clinical validation studies. These biomarkers will allow early diagnosis and monitoring of
sepsis progression and will help patient stratification for targeted therapies.
摘要
项目成果
期刊论文数量(0)
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FLOREA LUPU的其他文献
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{{ truncateString('FLOREA LUPU', 18)}}的其他基金
COBRE: OK MED RES FOUND: CORE I: IN VITRO MICROSCOPY CORE
COBRE:确定医学研究成果:核心 I:体外显微镜核心
- 批准号:
8168454 - 财政年份:2010
- 资助金额:
$ 55.43万 - 项目类别:
EPCR, TAFI as Regulators of PMN/Endothelial Interaction
EPCR、TAFI 作为 PMN/内皮相互作用的调节剂
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7939125 - 财政年份:2009
- 资助金额:
$ 55.43万 - 项目类别:
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