Determinants of 5 Year Progression of Muscle Dysfunction and Inactivity in COPDGene Participants Diversity Supplement

COPDGene 参与者的肌肉功能障碍和缺乏活动 5 年进展的决定因素 Diversity Supplement

• 批准号: 10361279
• 负责人: Alessandra Adami
• 金额: $ 7.02万
• 依托单位: LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-05-01 至 2023-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10361279
• 关键词: 2019-nCoV; Acute; Affect; Binge Eating; Breathing; COVID-19; Cardiovascular Diseases; Career Choice; Cause of Death; Centers for Disease Control and Prevention (U.S.); Characteristics; Chronic; Chronic Disease; Chronic Obstructive Airway Disease; Chronic lung disease; Communities; Country; Dimensions; Disease; Dyspnea; Elderly; Face; Fatigue; Functional disorder; Future; Glucose; Health; Health Status; Health behavior; Home; Household; Human; Impairment; Individual; Infection; Inflammatory; Lipids; Lung; Lung diseases; Malignant Neoplasms; Mental Depression; Mental Health; Muscle; Muscular Atrophy; Oxidative Stress; Parents; Participant; Pathogenesis; Pathology; Patients; Physical Exercise; Physical activity; Publishing; Quality of life; Reporting; Respiratory Therapy; Rhode Island; Risk; Severities; Shelter facility; Sleep Disorders; Social Interaction; Students; Symptoms; Time; Training; Universities; Virus Diseases; exercise capacity; exercise intolerance; mortality; muscle form; novel coronavirus; physical inactivity; programs; pulmonary function; pulmonary rehabilitation; severe COVID-19; social; tool; transmission process; virtual

ABSTRACT COVID-19 disease is a highly transmittable viral infection caused by the novel coronavirus severe acute respiratory syndrome coronavirus 2. Rapid human-to-human transmission has forced countries to implement restrictions to reduce the rate and impact of community spread. Advice for social restrictions was especially directed to the elderly and individuals with pre-existing chronic conditions, who are at greater risk of developing severe COVID-19 disease. These restrictions led to many individuals sheltering in their homes, in solitary or household isolation, for weeks or more at a time, affecting their social interactions and increasing poor health behaviors such as binge eating and physical inactivity. Reduced daily physical activity underlies many detrimental facets to health, including but not limited to poor glucose and lipid control, cardiovascular disease, cancer and a pro-inflammatory state. The CDC has identified physical inactivity as an “actual cause” of chronic disease, which contributes to the pathology and progression of many diseases including chronic obstructive pulmonary disease (COPD). COPD is a progressive lung disease that causes breathing difficulties, and, until COVID-19, was the 4th leading cause of death in the USA. In COPD, physical inactivity is associated with muscle dysfunction (e.g., loss of muscle mass, low oxidative capacity and increased oxidative stress) and exercise intolerance. Physical activity and exercise capacity are the strongest predictors of early mortality in COPD, rather than the severity of pulmonary function impairment. Many COPD patients report that the social restrictions imposed to mitigate COVID-19 exacerbated physical inactivity, increased depression and reduced quality-of-life. This study will assess the effect of COVID-19 restrictions on physical activity, symptoms, depression and quality-of-life. Fifty individuals who had these assessments made prior to COVID-19 restrictions in the parent Muscle Health Study (R01HL151452), will repeat these assessments now, after COVID-19 restrictions were implemented. In the past twelve months several studies were published elucidating the characteristics, pathogenesis and acute complications of COVID-19 disease, however the longer-term consequences are still unknown. Future impacts are especially relevant for patients with lung conditions such as COPD who are at greater risk of persistent consequences for at least 6 months after infection (e.g., dyspnea, fatigue, poor mental health, sleep problems). This proposal will provide evidence to support and promote efforts to re-tool pulmonary rehabilitation programs to impart impactful benefits in the COPD patients using virtual formats. Furthermore, this study would pave a career path for Mr. Baez, a Master’s Student at the University of Rhode Island, to pursue his training in respiratory therapy for chronic lung disease patients.

摘要 COVID-19疾病是一种由新型冠状病毒严重急性 呼吸道综合征冠状病毒2.快速的人际传播迫使各国实施 限制，以减少社区传播的速度和影响。特别是对社会限制的建议 针对老年人和患有预先存在的慢性病的人，他们有更大的发展风险， 严重的COVID-19疾病。这些限制导致许多人在家中、单独或 家庭隔离，一次长达数周或更长时间，影响他们的社会交往，并使健康状况恶化 暴饮暴食和缺乏运动等行为。日常体力活动减少是许多 对健康有害的方面，包括但不限于葡萄糖和脂质控制不良，心血管疾病， 癌症和促炎状态。疾病预防控制中心已经确定身体不活动是慢性疾病的“实际原因”。 疾病，这有助于许多疾病的病理和进展，包括慢性阻塞性肺疾病 肺疾病（COPD）。 COPD是一种导致呼吸困难的进行性肺部疾病，在COVID-19之前， 美国的死因。在COPD中，缺乏身体活动与肌肉功能障碍有关（例如，损失 肌肉质量、低氧化能力和增加的氧化应激）和运动不耐受。身体活动 和运动能力是COPD早期死亡率的最强预测因子，而不是COPD的严重程度。 肺功能损害许多COPD患者报告说，为缓解COPD而施加的社会限制 COVID-19加剧了身体活动不足，增加了抑郁症，降低了生活质量。本研究将 评估COVID-19限制对身体活动、症状、抑郁和生活质量的影响。五十 在母体肌肉健康研究中，在COVID-19限制之前进行这些评估的个人 （R 01 HL 151452）将在COVID-19限制措施实施后重复这些评估。 在过去的12个月里，发表了几项研究，阐明了其特征、发病机制和 COVID-19疾病的急性并发症，但长期后果仍未知。未来 影响对于患有肺部疾病的患者尤其相关，例如COPD，他们的风险更大， 感染后至少6个月的持续后果（例如，呼吸困难、疲劳、心理健康状况差、睡眠 问题）。这项提案将提供证据，支持和促进重新装备肺 康复计划，使用虚拟格式为COPD患者带来有影响力的益处。此外，委员会认为， 这项研究将为罗得岛大学的硕士生贝兹先生铺平职业道路， 继续接受为慢性肺病患者进行呼吸治疗的培训。