BIOLOGICAL TESTING FACILITY - "CONTRACEPTIVE TARGET WEB APPLICATIONS"
BIOLOGICAL TESTING FACILITY - "CONTRACEPTIVE TARGET WEB APPLICATIONS"
批准号:
10361637
负责人:
Toufan Parman
金额:
$19.98万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2021
资助国家:
美国
项目状态:
已结题
起止时间:
2021-01-07 至 2023-01-06
关键词:
AreaBioinformaticsBiological TestingClinicalClinical TrialsCollaborationsContraceptive AgentsContraceptive AvailabilityContraceptive DevicesDataDatabasesDevelopmentDevicesDrug FormulationsEvaluationIn VitroInternetInvestigational New Drug ApplicationKnowledgeMaintenancePharmaceutical PreparationsPhasePreparationProcessResearch PersonnelSafetySystemToxicologyUpdateWorkcontraceptive targetdesigndrug discoverydrug testingefficacy evaluationin vivonext generationnovelnovel strategiespre-clinicalreproductivestability testinguser-friendlyweb appweb site
中文摘要
早期非甾体避孕药发现和发展的一个主要障碍是
英文摘要
One major obstacle in early phase non-steroidal contraceptive discovery and development is
limited by known targets and readily accessibility of this information. It is important to facilitate
the discovery, curation and availability of contraceptive targets with the aim of developing new
approaches to advance next generation of safe contraceptive drug/device. To alleviate this
obstacle, bioinformatics driven approach to identify and curate those targets from the existing
databases was established. To further allow easy accessibility and friendly user interface for this
database, a web application is needed. The Biological Testing Facility has bioinformatics and web
design and application capability to achieve this task, in addition to permit rapid evaluation (in
vitro and in vivo) of new compositions of matter to the target, efficacy evaluation, safety/
toxicology assessment, drug formulations, delivery systems, and devices for contraceptives
followed by clinical batch preparation/ release and continued stability testing of drugs to be
evaluated in clinical trials. The BTF provides overall project management and the capabilities to
support all phases of novel target product identification, drug discovery/ optimization, preclinical
activities and development of contraceptives and associated tasks leading to the filing of
investigational new drug (IND) applications.
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