BIOLOGICAL TESTING FACILITY - "CONTRACEPTIVE TARGET WEB APPLICATIONS"

早期非类固醇避孕药发现和开发的一个主要障碍是 受限于已知目标和这些信息的易获得性。重要的是要促进 避孕目标的发现、管理和可用性，目的是开发新的 推进下一代安全避孕药/避孕器具的途径。来缓解这种状况 障碍，生物信息学驱动的方法，从现有的识别和管理这些目标 建立了数据库。为了进一步允许轻松访问和友好的用户界面， 数据库，则需要Web应用程序。生物检测机构拥有生物信息学和网络 设计和应用能力以实现这一任务，此外还允许快速评估(在 体外和体内)新物质组合物对靶的作用、疗效评价、安全性/ 毒理学评估、药物配方、给药系统和避孕用具 其次是临床批次制剂/释放和药物的持续稳定性试验 在临床试验中进行评估。BTF提供了全面的项目管理和以下功能 支持新目标产品识别、药物发现/优化、临床前的所有阶段 避孕药具的活动和发展以及相关任务，导致提交 研究中的新药(IND)应用。

One major obstacle in early phase non-steroidal contraceptive discovery and development is limited by known targets and readily accessibility of this information. It is important to facilitate the discovery, curation and availability of contraceptive targets with the aim of developing new approaches to advance next generation of safe contraceptive drug/device. To alleviate this obstacle, bioinformatics driven approach to identify and curate those targets from the existing databases was established. To further allow easy accessibility and friendly user interface for this database, a web application is needed. The Biological Testing Facility has bioinformatics and web design and application capability to achieve this task, in addition to permit rapid evaluation (in vitro and in vivo) of new compositions of matter to the target, efficacy evaluation, safety/ toxicology assessment, drug formulations, delivery systems, and devices for contraceptives followed by clinical batch preparation/ release and continued stability testing of drugs to be evaluated in clinical trials. The BTF provides overall project management and the capabilities to support all phases of novel target product identification, drug discovery/ optimization, preclinical activities and development of contraceptives and associated tasks leading to the filing of investigational new drug (IND) applications.