Administrative Supplement to Regulators of retinal metabolism in healthy and degenerating retinas

摘要： 视网膜有很高的代谢活性，视网膜退行性变与 线粒体功能障碍、代谢失调和毒性氧化损伤。然而， 关于新陈代谢在正常情况下是如何维持的，或者新陈代谢是如何失调的，我们知之甚少 在退化的视网膜中。AMPK(AMP-激活蛋白激酶)是一种重要的代谢调节因子 在高度代谢的组织中，是调节光感受器新陈代谢的候选分子，其 在这项拟议的项目中，将严格研究视网膜新陈代谢中的作用，使用 功能和丧失功能的方法。过氧化物酶体增殖物激活受体γ 辅活化子-α(pgc-1α)和β(pgc-1β)是线粒体生物发生的关键调节因子。 AMPK是PGC-1的重要调节因子 活动。我们在这项研究中的目标是确定AMPK和PGC-1在视网膜中的作用 光感受器。

Abstract: The retina hashigh metabolic activity,and retinal degenerations have been associated with mitochondrial dysfunction, dysregulation of metabolism, and toxic oxidative damage. However, little is known about how metabolism is maintained under normal conditions or is dysregulated in degenerating retinas. AMPK (AMP-activated protein kinase)is a key regulator of metabolism in highly metabolic tissues and is a candidate to regulate metabolism in photoreceptors, and its role in retinal metabolism will be rigorously studied in this proposed project using both gain-of- function and loss-of-function approaches. Peroxisome proliferator-activated receptor gamma coactivator-alpha (PGC-1α) and beta (PGC-1β) are key regulators of mitochondrialbiogenesis. Adenosine monophosphate dependent kinase (AMPK) is an important regulator of PGC-1 activity. Our goal in this study isto determine the rolesof AMPK and PGC-1activity in retinal photoreceptors.