Comprehensive Genomics Shared Facility

综合基因组学共享设施

• 批准号: 10362781
• 负责人: MICHAEL R CROWLEY
• 金额: $ 17.29万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-03-28 至 2022-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10362781
• 关键词: Animal Model; Bacterial Genome; Basic Science; Biological Assay; Biotechnology; CSF3 gene; Cancer Center; Cancer cell line; ChIP-seq; Clinic; Clinical; Clinical Research; Comprehensive Cancer Center; Consult; Consultations; Custom; DNA; DNA sequencing; Data; Data Analyses; Data Set; Development; Dideoxy Chain Termination DNA Sequencing; Environment; Equipment; Genes; Genetic; Genomics; Genotype; Gnotobiotic; Goals; Grant; Homeostasis; Human Cell Line; Human Genome; Human body; Individual; Institutes; Investments; Malignant Neoplasms; Metabolism; Metagenomics; Methodology; MicroRNAs; Microarray Analysis; Mission; Mitochondria; Modernization; Molecular; Molecular Analysis; Molecular Biology; Molecular Conformation; Neoplasm Metastasis; Patients; Population; Production; Provider; Recommendation; Research; Research Design; Research Personnel; Resources; Ribosomes; Running; SNP genotyping; Sampling; Services; Site; Technology; Translational Research; anticancer research; arm; cancer genomics; cancer type; cell type; clinical sequencing; cost; design; exome sequencing; experimental analysis; experimental study; gene cloning; genetic technology; genome sequencing; genomic platform; genomic tools; high dimensionality; instrument; member; microbial; microbiome; mutation screening; next generation; next generation sequencing; personalized medicine; precision medicine; research study; tool; transcriptome sequencing; tumor; whole genome

MOLECULAR ANALYSIS / TRANSLATION RESEARCH GROUP COMPREHENSIVE GENOMICS SHARED FACILITY (CGSF) ABSTRACT The goal of the Comprehensive Genomics Shared Facility (CGSF) is to provide Cancer Center investigators access to cutting-edge genomic resources and methodologies designed to facilitate and strengthen the quality of genetic, genomic, and molecular studies in cancer related research. The Comprehensive Genomics Shared Facility accomplishes this goal through two interrelated components: the on campus UAB Next-Generation and Sanger Sequencing (NGSS) arm, and the HudsonAlpha Institute for Biotechnology (HAIB) Next-Generation and Clinical Sequencing arm. This arrangement provides UAB Cancer Center members unprecedented access to state-of-the-art technologies for genetic and genomic analysis for basic research and clinical studies. Each component brings valuable resources to center members. The NGSS provides onsite consultation and service for various projects that require different types of genomic technologies. These include standard Sanger sequencing, human cell line identification (including cancer cell lines), SNP genotyping assays and Next-Generation Sequencing services (RNA-Seq, ChIP-Seq, microRNA-Seq, Exome-Seq, Custom amplicons, Microbiome, Metagenomics, and mitochondrial sequencing). The HAIB component offers very high throughput services for production-level whole genome sequencing and support for development and routine processing of clinical samples that require or benefit from a CLIA environment. The CGSF supports basic researchers investigating the mechanisms of cancer development, progression and metastasis as well as clinical researchers pursuing precision medicine approaches and provides the tools they need to efficiently and effectively contribute significant findings to the field of cancer research.

分子分析/翻译研究组 综合基因组学共享因子（CGSF） 摘要 综合基因组学共享设施（CGSF）的目标是为癌症中心的研究人员提供 获得旨在促进和加强质量的尖端基因组资源和方法 癌症相关研究中的遗传、基因组和分子研究。共享的综合基因组学 设施通过两个相互关联的组成部分来实现这一目标：校园UAB下一代和 桑格测序（NGSS）臂，和哈德逊阿尔法生物技术研究所（HAIB）下一代 这项安排为UAB癌症中心成员提供了前所未有的 为基础研究和临床研究提供最先进的遗传和基因组分析技术。 每个组件都为中心成员带来了宝贵的资源。NGSS提供现场咨询， 为需要不同类型基因组技术的各种项目提供服务。其中包括标准 桑格测序、人细胞系鉴定（包括癌细胞系）、SNP基因分型测定和 下一代测序服务（RNA-Seq，ChIP-Seq，microRNA-Seq，Exome-Seq，定制扩增子， 微生物组学、宏基因组学和线粒体测序）。HAIB组件提供非常高的吞吐量 提供生产级全基因组测序服务，并为开发和常规处理提供支持 需要或受益于CLIA环境的临床样本。CGSF支持基础研究人员 研究癌症发生、发展和转移的机制以及临床 研究人员追求精确的医学方法，并提供他们需要的工具， 有效地为癌症研究领域做出重大贡献。