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COPY NUMBER VARIATION AND LUNG CANCER: DISEASE RISK, PREDICTION AND MECHANISM

COPY NUMBER VARIATION AND LUNG CANCER: DISEASE RISK, PREDICTION AND MECHANISM
拷贝数变异与肺癌:疾病风险、预测和机制
批准号:
10615939
负责人:
Feifei Xiao
金额:
$22.61万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2022
资助国家:
美国
项目状态:
已结题
起止时间:
2022-04-30 至 2023-08-31

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中文摘要
翻译
项目总结
英文摘要
PROJECT SUMMARY Lung cancer (LC) is the leading cause of cancer related death in the United States. Although genome-wide association studies have identified many LC susceptibility loci, most of its heritability remains hidden and might be further explained by copy number variation. To date, studies have provided robust evidence to support the unique roles of copy number variants (CNVs) in many cancer types, however, their risk effect and molecular mechanisms contributing to LC is still unclear. The overall objective of this R21 is to conduct a comprehensive study leveraging datasets from the large-scale Transdisciplinary Research in Cancer of the Lung (TRICL) consortium, a Lung eQTL dataset and two public data resources to discover high confidence CNVs predisposing to LC across histological subtypes. The central hypothesis is that CNVs are associated with LC susceptibility, regulate gene expression and have a potential to serve as novel biomarkers for prediction of LC. This hypothesis will be tested by pursuing two specific aims: 1) Determine the effect of CNVs on LC risk; and 2) Characterize the regulatory impact of CNVs on gene expression. In Aim 1, with a large collection of data from LC patients and controls (n=36,068 total) from the TRICL consortium, we will rigorously evaluate CNVs as novel biomarkers for lung cancer predisposition. First, CNVs will be generated by a change- point based method, modSaRa2, and a Hidden Markov Model based approach, PennCNV. Then using a gene- based collapsing association test, duplications or deletions associated with LC will be determined. These significant associations will be validated by an independent replication dataset, the Environment and Genetics in Lung cancer Etiology (EAGLE) dataset (n=4,221). We will identify novel pathways, networks, and interactions underlying LC, which are significantly enriched by LC-susceptibility CNVs. Gaining insight into the underlying biological mechanisms of the influence of CNVs on LC risk is critical; therefore, in Aim 2, we will evaluate the regulatory impact of CNVs on gene expression, which is intermediate to many complex phenotypes. Genomic measures from the Lung eQTL study (n=1,038) and the public dataset GTEx (n=383) will be used to evaluate the associations between the identified LC-susceptibility CNVs and expression of their corresponding genes. A functional study with experimental design will be followed to test the downstream functions of the newly identified CNV regulated gene expression in growth and progression of cancer cells. This project has the potential to fill a gap in current knowledge about the utility of CNV as a new type of genetic variation influencing the risk of LC and provide a better understanding of the underlying molecular mechanisms. Our innovative, integrative genetics, genomics and bioinformatics approaches will identify novel genetic predictors that predispose to LC. This study has enormous potential for providing critical new directions that will allow exploration of a range of research questions about how CNV characteristics can be utilized for future risk management and treatment of human complex diseases.
期刊论文(4)
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科研奖励(0)
会议论文
Shall genomic correlation structure be considered in copy number variants detection?
拷贝数变异检测中是否应考虑基因组相关结构?
DOI: 10.1093/bib/bbab215
发表时间: 2021
期刊: Briefings in bioinformatics
影响因子: 9.5
作者: [Qin,Fei, Luo,Xizhi, Cai,Guoshuai, Xiao,Feifei]
通讯作者: Xiao,Feifei
BMI-CNV: a Bayesian framework for multiple genotyping platforms detection of copy number variants.
BMI-CNV:用于检测拷贝数变异的多个基因分型平台的贝叶斯框架。
DOI: 10.1093/genetics/iyac147
发表时间: 2022
期刊: Genetics
影响因子: 3.3
作者: [Luo,Xizhi, Cai,Guoshuai, Mclain,AlexanderC, Amos,ChristopherI, Cai,Bo, Xiao,Feifei]
通讯作者: Xiao,Feifei
Copy Number Variation and Lung Cancer: Disease Risk and Mechanisms
国内基金
海外基金
关于群上的短零和序列及其cross number的研究
  • 批准号:
    11501561
  • 项目类别:
    青年科学基金项目
  • 资助金额:
    18.0万元
  • 批准年份:
    2015
  • 负责人:
    王林林
  • 依托单位: