Investigation of Momentary, Prospective Associations Between Working Memory and Eating Behavior in Children

儿童工作记忆与饮食行为之间的瞬时、前瞻性关联的调查

• 批准号: 10452888
• 负责人: Andrea Beth Goldschmidt
• 金额: $ 3万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-24 至 2021-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10452888
• 关键词: Investigation; Momentary; Prospective; Associations; Between

PROJECT SUMMARY/ABSTRACT - NO CHANGE FROM ORIGINAL Pediatric overweight and obesity continue to be major public health issues. Loss of control (LOC) eating is an obesity-related phenotype that affects approximately 30% of children and adolescents with overweight/obesity and may impede successful weight control. Both pediatric overweight/obesity and LOC eating are associated with relative deficiencies in executive functioning. In particular, our recently published data suggest that youth with LOC eating and concomitant overweight/obesity have poorer working memory (WM) than their overweight/obese and non-overweight peers. These decrements may inhibit their abilities to adaptively respond to environmental and internal cues related to eating. A limitation of prior research is that it has largely focused on individual differences in neurocognitive processes, thereby failing to inform our understanding of how these processes may drive eating behavior on a moment-to-moment basis and limiting development of interventions that can be delivered in real time when individuals are most at risk for engaging in LOC eating. This R03 application proposes to use ecological momentary assessment (EMA) and validated dietary assessment (Nutritional Database System for Research; NDSR) to assess eating behavior in the context of acute WM, and assess whether fluctuations in WM are related to LOC eating or excess energy intake in children (10-17 years) with LOC eating and overweight/obesity relative to their overweight/obese and non- overweight peers. The applicant is a current K23 recipient (DK-105234) whose program of research has focused on clarifying the etiology and maintenance of LOC eating in youth with overweight/obesity. The applicant's expertise in momentary assessment of affective and neurocognitive processes underlying eating- and weight-related disorders forms the basis of the current proposal. In particular, the applicant has extensive experience utilizing EMA to understand antecedents and consequences of maladaptive eating in near real time in the natural environment. EMA is ideal for investigating eating behavior in the context of WM as it allows for prospective, momentary assessment of within- and between-person variables of interest. In the proposed study, participants will monitor their eating behavior via EMA for 14 days, and dietary recalls completed on 3 randomly selected days during this same period. They will also complete EMA tasks of numerical and spatial WM. Data on potential covariates (e.g., mood) will also be collected via EMA. These data will clarify timing and trajectory of LOC eating and dietary intake in relation to WM performance. This study, which is the first to use EMA to clarify if momentary WM performance is related to eating behavior, has clear potential to advance scientific and clinical understanding of mechanisms that promote the occurrence of maladaptive eating in youth and inform interventions to alleviate their cumulative personal and societal burden. Furthermore, this proposal provides a clear pathway to independence for the investigator, and will enable her to pursue future R01 funding to understand the impact of WM training on eating- and weight-related outcomes.

项目总结/摘要-与原始文件相比无变更 儿童超重和肥胖仍然是主要的公共卫生问题。饮食失控（Loss of Control） 肥胖相关表型，影响约30%的超重/肥胖儿童和青少年 并且可能妨碍成功的体重控制。儿童超重/肥胖和暴食都与 在执行功能方面有相对缺陷。特别是，我们最近公布的数据表明， 饮食过量和伴随的超重/肥胖的人的工作记忆（WM）比他们的工作记忆（WM）更差。 超重/肥胖和非超重同龄人。这些减少可能会抑制他们的能力， 对与进食有关的环境和内部线索作出反应。先前研究的一个局限性是， 专注于神经认知过程中的个体差异，从而未能告知我们对 这些过程是如何在每时每刻驱动进食行为，并限制 当个人最有可能进行LOC饮食时，可以真实的实施干预措施。 本R 03申请建议使用生态瞬时评估（EMA）和经验证的膳食 研究营养数据库系统（Nutritional Database System for Research; NDSR），用于评估以下情况下的饮食行为： 急性WM，并评估WM的波动是否与进食或过量能量摄入有关， 与超重/肥胖和非肥胖儿童相比， 超重的同龄人申请人是目前的K23接受者（DK-105234），其研究计划 重点是阐明超重/肥胖青年暴食的病因和维持。的 申请人在瞬间评估进食背后的情感和神经认知过程方面的专业知识， 和体重相关的疾病构成了目前提案的基础。特别地，申请人具有广泛的 利用EMA了解适应不良饮食的前因和后果的经验，接近真实的时间 在自然环境中。EMA是研究WM背景下饮食行为的理想选择，因为它允许 对感兴趣的人内和人与人之间变量进行前瞻性、瞬时评估。拟议 在这项研究中，参与者将通过EMA监测他们的饮食行为14天，并在3天内完成饮食回忆。 在同一时期随机选择的日子。他们还将完成数字和空间的EMA任务 WM.潜在协变量的数据（例如，情绪）也将通过EMA收集。这些数据将澄清时间和 LOC饮食和膳食摄入量与WM表现的关系轨迹。这项研究，这是第一次使用 EMA澄清瞬时WM表现是否与饮食行为有关，具有明显的推进潜力 科学和临床的理解机制，促进发生适应不良的饮食在青年 并为干预措施提供信息，以减轻他们累积的个人和社会负担。此外，该提案 为研究者的独立性提供了明确的途径，并将使她能够寻求未来的R 01资金 了解WM训练对饮食和体重相关结果的影响。