Intrinsic Functional Architecture of Dentate Nuclei in Autism Spectrum Disorder

自闭症谱系障碍中齿状核的内在功能结构

• 批准号: 10458856
• 负责人: Sheeba Anteraper
• 金额: $ 14.68万
• 依托单位: CARLE FOUNDATION
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-03-01 至 2024-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10458856
• 关键词: Intrinsic; Functional; Architecture; Dentate; Nuclei

Summary/Abstract Functional neuroanatomy in human dentate nucleus (DN) remains largely unmapped. Functional magnetic resonance imaging research has redefined broad categories of functional division in the human brain showing that primary processing, attentional “task positive” processing, and default-mode “task negative” processing are three central poles of neural macro-scale specialization. This new macro-scale understanding of the range and poles of brain function has revealed that not only cerebral cortex, but also thalamus, striatum, and cerebellar cortex contribute to the full spectrum of human neural organization. Whether functional specialization in DN obeys a similar set of macroscale divisions, and whether DN is yet another compartment of full-spectrum representation of human brain function remains unknown. This proposal aims to explore functional territories in human DN. Preliminary results using data-driven gradient-based clustering analysis reveal three functional zones as indexed by high spatio-temporal resolution resting-state MRI, and that these three distinct territories contribute uniquely to default-mode, salience-motor, and visual brain networks. Our goal is to replicate the results in an independent larger sample to provide a systems neuroscience substrate for cerebellar output to influence all broad categories of neural control – namely default-mode, attentional, and multiple unimodal streams of information processing including motor and visual. The overarching aim of this proposal is to apply these functional territories towards clinical translation, specifically in the context of Autism Spectrum Disorder.

总结/摘要 人类齿状核（DN）的功能神经解剖学仍然在很大程度上未映射。功能磁 共振成像研究重新定义了人类大脑中功能划分的广泛类别， 初级加工、注意力“任务积极”加工和默认模式“任务消极”加工 是神经宏观特化的三个中心极点。这种新的宏观尺度的理解范围 大脑功能的两极显示，不仅大脑皮层，而且丘脑，纹状体， 小脑皮层对人类神经组织的全方位贡献。是否有效 DN中的专门化遵循一组类似的宏观划分，DN是否是另一个隔间 人类大脑功能的全谱表示仍然是未知的。该提案旨在探讨 人类DN的功能区域。使用数据驱动的基于梯度的聚类分析的初步结果 揭示了高时空分辨率静息态MRI所指示的三个功能区，并且这些功能区 三个不同的区域对默认模式、显著性运动和视觉脑网络有独特的贡献。我们 我们的目标是在一个独立的更大的样本中复制结果，以提供一个系统神经科学的基础， 小脑输出影响所有广泛类别的神经控制-即默认模式，注意力， 包括运动和视觉在内的多个单模态信息处理流。这项工作的首要目标是， 我的建议是将这些功能领域应用于临床翻译，特别是在自闭症的背景下 光谱紊乱