Intrinsic Functional Architecture of Dentate Nuclei in Autism Spectrum Disorder

自闭症谱系障碍中齿状核的内在功能结构

• 批准号: 10057096
• 负责人: Sheeba Anteraper
• 金额: --
• 依托单位: NORTHEASTERN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-05-08 至 2021-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10057096
• 关键词: Address; Anatomy; Architecture; Attention; Biological Markers; Brain; Brain imaging; Categories; Cerebellar Cortex; Cerebellar Diseases; Cerebellum; Cerebral cortex; Cluster Analysis; Communities; Corpus striatum structure; Data; Data Set; Dentate nucleus; Dorsal; Eye; Fiber; Functional Magnetic Resonance Imaging; Functional disorder; Goals; Hair; Head; Human; Knowledge; Magnetic Resonance Imaging; Methods; Motor; Neuroanatomy; Neurodevelopmental Disorder; Neurosciences; Output; Participant; Pattern; Population; Prediction of Response to Therapy; Process; Protocols documentation; Psychopathology; Research; Resolution; Rest; Sampling; Scanning; Severities; Stream; Symptoms; System; Thalamic structure; Therapeutic Intervention; Validation; Visual; analysis pipeline; autism spectrum disorder; awake; base; clinical heterogeneity; clinical translation; data acquisition; data exchange; emotional functioning; indexing; information processing; neuroimaging; neuroregulation; outcome forecast; relating to nervous system; repetitive behavior; social; spatiotemporal; structured data; targeted treatment; temporal measurement

Title: Intrinsic Functional Architecture of Dentate Nuclei in Autism Spectrum Disorder Functional neuroanatomy in human dentate nucleus (DN) remains largely unmapped. Functional magnetic resonance imaging research has redefined broad categories of functional division in the human brain showing that primary processing, attentional “task positive” processing, and default-mode “task negative” processing are three central poles of neural macro-scale specialization. This new macro-scale understanding of the range and poles of brain function has revealed that not only cerebral cortex, but also thalamus, striatum, and cerebellar cortex contribute to the full spectrum of human neural organization. Whether functional specialization in DN obeys a similar set of macroscale divisions, and whether DN is yet another compartment of full-spectrum representation of human brain function remains unknown. This proposal aims to explore functional territories in human DN. Preliminary results using data-driven gradient-based clustering analysis reveal three functional zones as indexed by high spatio-temporal resolution resting-state MRI, and that these three distinct territories contribute uniquely to default- mode, salience-motor, and visual brain networks. Our goal is to replicate the results in an independent larger sample to provide a systems neuroscience substrate for cerebellar output to influence all broad categories of neural control – namely default- mode, attentional, and multiple unimodal streams of information processing including motor and visual. The overarching aim of this proposal is to apply these functional territories towards clinical translation, specifically in the context of Autism Spectrum Disorder.

自闭症谱系中齿状核的固有功能结构 失序 人类齿状核(DN)的功能神经解剖学在很大程度上仍未被定位。 功能磁共振成像研究重新定义了广泛的类别 人脑的功能划分表明，初级加工、注意力“任务 正向加工和默认模式下的负向加工是三种核心加工方式 神经宏观专业化的两极。这种对宏观层面的新理解 大脑功能的范围和极点表明，不仅大脑皮层，而且 丘脑、纹状体和小脑皮质构成了人类神经的全谱。 组织。Dn中的函数专门化是否服从类似的宏观尺度集 除法，以及Dn是否是全谱表示的另一个隔间 人类的大脑功能仍不清楚。这项提案旨在探索功能 人类DN中的领土。使用数据驱动的基于梯度的聚类的初步结果 分析揭示了由高时空分辨率索引的三个功能区 休眠状态核磁共振，这三个不同的领域对违约有独特的贡献- 模式、突显-运动和视觉大脑网络。我们的目标是将结果复制到 一个独立的更大的样本，为 小脑输出影响所有神经控制的广泛类别--即默认-- 信息处理的模式、注意力和多个单峰数据流，包括 运动和视觉。本提案总体目标是应用这些功能 临床翻译领域，特别是在自闭症谱系背景下 无序。