Intrinsic Functional Architecture of Dentate Nuclei in Autism Spectrum Disorder

标题：自闭症谱系中齿状核的内在功能结构 紊乱 人类齿状核（DN）的功能神经解剖学在很大程度上仍然未知。 功能磁共振成像研究重新定义了广泛的类别 人脑的功能划分表明，初级处理、注意力“任务 积极”处理和默认模式的“任务消极”处理是三个核心 神经宏观尺度专业化的极点。这种新的宏观理解 大脑功能的范围和极点揭示了不仅大脑皮层，而且 丘脑、纹状体和小脑皮层对人类神经的全谱做出贡献 组织。 DN 中的功能专业化是否遵循一组相似的宏观尺度 划分，以及 DN 是否是全谱表示的另一个部分 人类大脑的功能仍然未知。本提案旨在探索功能性 人类 DN 中的领土。使用数据驱动的基于梯度的聚类的初步结果 分析揭示了高时空分辨率索引的三个功能区 静息态 MRI，这三个不同的区域对默认值有独特的贡献- 模式、显着运动和视觉大脑网络。我们的目标是复制结果 一个独立的较大样本，为系统神经科学基础提供 小脑输出影响神经控制的所有大类——即默认—— 模式、注意力和多个单峰信息处理流，包括 运动和视觉。该提案的总体目标是应用这些功能 临床转化领域，特别是在自闭症谱系的背景下 混乱。

Title: Intrinsic Functional Architecture of Dentate Nuclei in Autism Spectrum Disorder Functional neuroanatomy in human dentate nucleus (DN) remains largely unmapped. Functional magnetic resonance imaging research has redefined broad categories of functional division in the human brain showing that primary processing, attentional “task positive” processing, and default-mode “task negative” processing are three central poles of neural macro-scale specialization. This new macro-scale understanding of the range and poles of brain function has revealed that not only cerebral cortex, but also thalamus, striatum, and cerebellar cortex contribute to the full spectrum of human neural organization. Whether functional specialization in DN obeys a similar set of macroscale divisions, and whether DN is yet another compartment of full-spectrum representation of human brain function remains unknown. This proposal aims to explore functional territories in human DN. Preliminary results using data-driven gradient-based clustering analysis reveal three functional zones as indexed by high spatio-temporal resolution resting-state MRI, and that these three distinct territories contribute uniquely to default- mode, salience-motor, and visual brain networks. Our goal is to replicate the results in an independent larger sample to provide a systems neuroscience substrate for cerebellar output to influence all broad categories of neural control – namely default- mode, attentional, and multiple unimodal streams of information processing including motor and visual. The overarching aim of this proposal is to apply these functional territories towards clinical translation, specifically in the context of Autism Spectrum Disorder.