Longitudinal investigation of sociocultural and behavioral influences on symptom management, biological response, and functioning between Chinese and White breast cancer survivors.
社会文化和行为对中国和白人乳腺癌幸存者症状管理、生物反应和功能影响的纵向调查。
基本信息
- 批准号:10360588
- 负责人:
- 金额:$ 62.92万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-03-01 至 2026-02-28
- 项目状态:未结题
- 来源:
- 关键词:AcculturationAdherenceAffectAgeAnxietyAsianBehaviorBehavioralBeliefBiologicalBiologyBlood specimenBreast Cancer survivorBuffersCancer EtiologyCancer SurvivorCancer SurvivorshipChineseChinese AmericanChronicChronic stressCohort StudiesCommunicationCoping BehaviorCross-Sectional StudiesDataDevelopmentDiagnosisDietDietary PracticesDistressEatingEmotionalEmotional StressEquilibriumExerciseFatigueFeedbackFrightGrowthGuidelinesHealthHealth SciencesHydrocortisoneImmigrantImmigrationIncidenceIndividualInflammationInflammatoryIntakeInterventionInterviewInvestigationLeadLongitudinal prospective studyMalignant NeoplasmsMediatingMedicalMenopausal SymptomMental DepressionNot Hispanic or LatinoOutcomeOutcome StudyPainParticipantPathway interactionsPatient Self-ReportPhysical FunctionPhysical activityPopulationPopulation GrowthPreventionPsychological FactorsPsychological StressPsychosocial StressPublic HealthQuality of lifeRaceRecurrenceReportingResearchResourcesRiskSamplingSeveritiesSocial supportSocietiesSoy FoodsStressSurveysSymptomsTelephoneTimeTranslatingUnhealthy DietVegetablesWorkauthoritybasebehavior influencebiracialclinical carecopingcruciferous vegetablecultural valuescytokinediet and exercisedietaryfunctional declinefunctional outcomesgood dietgrasphealth care availabilityimprovedmalignant breast neoplasmpreferencepsychologicpsychological stressorpsychosocialracial differenceresilienceresponsesocialsocial culturesocioeconomic disadvantagesocioeconomicssoysymptom management
项目摘要
PROJECT SUMMARY
The number of US cancer survivors is growing rapidly, including a significant number of Chinese Americans
(CA), a group with an annual breast cancer growth rate of 1.1% and fast population growth due to immigration.
Over 63% of CAs are immigrants. Our preliminary study showed that more CA immigrant breast cancer
survivors (BCS) had fatigue, pain, and poor physical functioning relative to non-Hispanic White (NHW) BCS.
Low-acculturated CAs reported greater psychosocial stress (e.g. greater perceived threat and fear of losing
socioeconomic resources); however, they paradoxically reported less depression than NHWs. We do not know
why CA BCS appear emotionally resilient when they are physically vulnerable and often lack social resources
for coping (i.e., social support, socioeconomic resources and healthcare access). It is unclear whether such
resilience is actually a cultural response when many CAs believe that emotional stress causes cancer, and
thus they may underreport their distress. Unexpressed chronic stress is related to higher cortisol and
inflammation levels detrimental to health. It is also unknown whether CA BCS’ symptom burden persists over
time and how culture and social resources influence their ways of managing symptoms and further improving
quality of life. Prior data showed CA BCS eating more soy food and cruciferous vegetables than NHWs. Higher
soy intake reduces menopausal symptoms and fatigue. Yet, CA BCS had lower adherence to physical activity
guidelines than NHWs. Psychosocial stress, poor diet, insufficient exercise, fatigue, and pain are all related to
chronic inflammation. Yet, Chinese practices in healthy diet and emotional balance may decrease inflammation.
Our preliminary findings were based on self-reports, so we cannot explain how those multifaceted sociocultural
and individual factors are intertwined to affect inflammation in the body and outcome differences between the
two racial groups. To comprehensively understand sociocultural influence on individual coping behaviors and
how they in turn affect racial differences in biological responses (i.e., inflammation and cortisol stress markers),
symptom severity, and quality of life, we propose a bi-racial, cohort study among 260 CA BCS (1-5 years post
diagnosis) who will be age- and stage-matched to 260 NHW BCS. Utilizing a society-behavior-biology
multilevel framework, we will investigate the dynamics of sociocultural, psychological, and behavioral (diet and
exercise) influences on symptom severity, biological responses, and functional outcomes. Participants will
complete telephone survey interviews and provide blood samples at baseline and 6- and 12-month post-
baseline follow-ups. Next, in-depth individual interviews with a subset of samples will be conducted to
investigate in depth the causative factors in the pathways in order to develop individually and culturally
appropriate interventions conducive to improving clinical care for targeted cancer survivor populations. This is
well aligned with the Cancer Moonshot Initiative aimed at increasing symptom control and improving survival.
项目总结
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Judy Huei-yu Wang其他文献
Culturally Adapting a Video-Based Self-acupressure Intervention to Manage Symptoms for Black and Latina Breast Cancer Survivors
- DOI:
10.1007/s13187-025-02684-1 - 发表时间:
2025-07-12 - 期刊:
- 影响因子:1.300
- 作者:
Katarina E. AuBuchon;Amrita Bonthu;Lourdes Inbar-Albo;Thelma D. Jones;Jacqueline Beale;Claudia Campos-Galván;Laura A. Logie;Carla Arieta;Geng-Hao Liu;Alejandra Hurtado-de-Mendoza;Suzanne C. Danhauer;Kristi D. Graves;Judy Huei-yu Wang - 通讯作者:
Judy Huei-yu Wang
Judy Huei-yu Wang的其他文献
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{{ truncateString('Judy Huei-yu Wang', 18)}}的其他基金
Longitudinal investigation of sociocultural and behavioral influences on symptom management, biological response, and functioning between Chinese and White breast cancer survivors.
社会文化和行为对中国和白人乳腺癌幸存者症状管理、生物反应和功能影响的纵向调查。
- 批准号:
10595060 - 财政年份:2021
- 资助金额:
$ 62.92万 - 项目类别:
A web-based intervention to promote follow-up care communication and functional status of Chinese immigrant breast cancer survivors
基于网络的干预措施促进中国移民乳腺癌幸存者的后续护理沟通和功能状态
- 批准号:
9316194 - 财政年份:2017
- 资助金额:
$ 62.92万 - 项目类别:
Acupressure Intervention to Improve Fatigue and Physical Functioning of Chinese Immigrant Breast Cancer Survivors
穴位按摩干预改善中国移民乳腺癌幸存者的疲劳和身体机能
- 批准号:
9303325 - 财政年份:2016
- 资助金额:
$ 62.92万 - 项目类别:
Acupressure Intervention to Improve Fatigue and Physical Functioning of Chinese Immigrant Breast Cancer Survivors
穴位按摩干预改善中国移民乳腺癌幸存者的疲劳和身体机能
- 批准号:
9178314 - 财政年份:2016
- 资助金额:
$ 62.92万 - 项目类别:
A RCT TO PROMOTE MAMMOGRAPHY ADHERENCE AMONG CHINESE IMMIGRANT WOMEN
一项旨在促进中国移民女性坚持乳房X光检查的随机对照试验
- 批准号:
8102869 - 财政年份:2010
- 资助金额:
$ 62.92万 - 项目类别:
A RCT TO PROMOTE MAMMOGRAPHY ADHERENCE AMONG CHINESE IMMIGRANT WOMEN
一项旨在促进中国移民女性坚持乳房X光检查的随机对照试验
- 批准号:
8208134 - 财政年份:2010
- 资助金额:
$ 62.92万 - 项目类别:
A RCT TO PROMOTE MAMMOGRAPHY ADHERENCE AMONG CHINESE IMMIGRANT WOMEN
一项旨在促进中国移民女性坚持乳房X光检查的随机对照试验
- 批准号:
8591384 - 财政年份:2010
- 资助金额:
$ 62.92万 - 项目类别:
A RCT TO PROMOTE MAMMOGRAPHY ADHERENCE AMONG CHINESE IMMIGRANT WOMEN
一项旨在促进中国移民女性坚持乳房X光检查的随机对照试验
- 批准号:
7985939 - 财政年份:2010
- 资助金额:
$ 62.92万 - 项目类别:
A RCT TO PROMOTE MAMMOGRAPHY ADHERENCE AMONG CHINESE IMMIGRANT WOMEN
一项旨在促进中国移民女性坚持乳房X光检查的随机对照试验
- 批准号:
8410029 - 财政年份:2010
- 资助金额:
$ 62.92万 - 项目类别:
CULTURAL IMPACT ON ADAPTATION BETWEEN CHINESE AND WHITE BREAST CANCER SURVIVORS
文化对中国人和白人乳腺癌幸存者之间适应的影响
- 批准号:
7642928 - 财政年份:2009
- 资助金额:
$ 62.92万 - 项目类别:
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