Appalachian Node

阿巴拉契亚节点

• 批准号: 10359849
• 负责人: JANE M LIEBSCHUTZ
• 金额: $ 101.54万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-06-15 至 2024-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10359849
• 关键词: Academic Medical Centers; Address; Appalachian Region; Area; Bacterial Infections; Bioinformatics; Caring; Clinical; Clinical Investigator; Clinical Research; Clinical Sciences; Clinical Trials Network; Coal; Coal Mining; Collaborations; Communities; Complex; County; Data; Databases; Discipline; Distress; Economics; Electronic Health Record; Employment Opportunities; Endocarditis; Ensure; Environmental Risk Factor; Epidemic; Evidence based practice; Family; Geography; HIV; Health; Health Information System; Health Policy; Health Technology; Health system; Healthcare; Healthcare Systems; Helping to End Addiction Long-term; Hepatitis B; Hepatitis C; Incentives; Industry; Infrastructure; Institutes; Institution; Insurance Carriers; Integrated Health Care Systems; Intervention; Kentucky; Leadership; Learning; Life Expectancy; Long-Term Care; Manuals; Medical; Medicine; Morbidity - disease rate; National Institute of Drug Abuse; Neonatal Abstinence Syndrome; Ohio; Opiate Addiction; Opioid; Overdose; Patients; Pennsylvania; Persons; Pharmaceutical Preparations; Pharmacists; Pharmacy facility; Plant Roots; Play; Policies; Professional Education; Protocols documentation; Provider; Public Health; Publications; Records; Recovery; Research; Research Personnel; Resource-limited setting; Resources; Risk; Risk Factors; Role; Rural; Series; Site; System; Tennessee; Testing; Training Programs; Translational Research; Transportation; Underserved Population; Unemployment; United States National Institutes of Health; Universities; West Virginia; Work; addiction; base; buprenorphine treatment; chronic pain; college; evidence base; experience; healing; improved; injection drug use; innovation; mobile computing; mortality; multi-site trial; multidisciplinary; novel; opioid epidemic; opioid misuse; opioid mortality; opioid overdose; opioid use; opioid use disorder; outreach; overdose death; peer; practice-based research network; programs; recruit; relapse risk; response; rural area; rural counties; rurality; smartphone Application; social; social exclusion; substance misuse; substance use; substance use treatment; syndemic; treatment program; underserved rural area; urban area; wearable device

Abstract: The Appalachian Node of NIDA Clinical Trials Network (CTN) will address clinical research questions that arise from Central Appalachia, an epicenter of the current opioid epidemic. It has among the highest rates of opioid overdose deaths and related morbidities in the nation. Its rural geography, culture of independence, strained economy and lack of access to substance use treatment have all contributed to the epidemic. Joining together University of Pittsburgh (Pitt), West Virginia University (WVU) and Penn State College of Medicine (PSU), the Appalachian Node will be led by experienced clinical investigators, Drs. Jane Liebschutz (Pitt) and Judith Feinberg (WVU). The node will bring together successful multi-disciplinary co-investigators, many of whom had prior CTN experience in other established nodes and who have been recruited to these institutions to respond to the regional substance use epidemic. The affiliated academic medical centers cover central and western Pennsylvania (PA) and all of West Virginia (WV) and have extensive bioinformatics databases with electronic health record and claims data. Use of a Stakeholder Advisory Group, support from regional payors, and close ties with state and local policy and public health officials will ensure that research has relevance and a high likelihood of sustainability after study completion. The three aims of the node are to: 1) conduct multisite trials that will address the current opioid crisis (and other substance misuse), with an emphasis on conducting studies among rural and other underserved populations, 2) propose studies to test innovative uses of existing resources (local pharmacies, peer navigators/peer recovery coaches, mobile technology, state-of-the-art health information systems) to implement evidence-based practices that will extend state-of-the-art care into resource-poor regions, both rural and urban, and 3) disseminate CTN findings to regional payers and policymakers, practitioners, and the community. The node will define local solutions to overcome the complex interplay of barriers in underserved rural and urban areas. The combination of our resources and those provided by the CTN will enable us to make a significant impact on the opioid epidemic in central Appalachia and nationally. Proposed studies built on work of node investigators include: 1) Serious Bacterial Infections Related to Injection Drug Use: Quality Metrics and Intervention (Liebschutz, Pollini), 2) Pharmacist-Assisted Buprenorphine Treatment (Winstanley), 3) Leveraging the Learning Health System to Incentivize Medication-Assisted Recovery for Opioid Use Disorder (Kraemer), and 4) An “Early Warning” System for Relapse Risk with Smartphone Apps and Wearable Devices (Kawasaki, Winstanley).

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