Mechanical Regulation of Cell Fate and Multi-Scale Function in the Developing Meniscus

半月板发育中细胞命运和多尺度功能的机械调节

基本信息

  • 批准号:
    10359683
  • 负责人:
  • 金额:
    $ 51.85万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2019
  • 资助国家:
    美国
  • 起止时间:
    2019-04-01 至 2024-02-29
  • 项目状态:
    已结题

项目摘要

Abstract The meniscus plays a vital role in healthy knee function. However, given the centrality of this tissue in load transfer and the demanding physical environment, injury is common and healing in adults is limited. The current lack of regenerative solutions for knee meniscus injury arises, in part, from the significant gap in our understanding of the cellular origins and regulation of meniscus tissue during development. While it is well appreciated that the meniscus arises from a specialized progenitor cell population that first defines the forming synovial joint (interzone cells), the regulation and timing of the differentiation of these cells, their phenotypic heterogeneity, the type and timing of matrix that these cells produce within defined intervals, how this matrix matures and feeds back to influence cell function and fate, and the role of active mechanical forces (that begin during the first stages of joint motion), remain poorly understood. To address these limitations, this proposal uses a series of novel mouse models and micro-scale experimental techniques to investigate the origin and track the fate and function of cells that comprise the mature meniscus. We will also define the time-evolving structural and mechanical features of the developing matrix, and query the role of joint loading and cellular response to mechanical inputs in this developmental paradigm. Our central hypothesis is that a common pool of meniscal progenitor cells arises from the interzone, that these cells are acted on by microenvironmental cues defined by early matrix assembly and active mechanical signals (that arise with joint loading), and that these inputs act together to refine and direct meniscus maturation, enabling its adult function.
摘要

项目成果

期刊论文数量(0)
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EIKI KOYAMA其他文献

EIKI KOYAMA的其他文献

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{{ truncateString('EIKI KOYAMA', 18)}}的其他基金

Evaluation of Prg4 as a New Therapy for TMJ Disc Degeneration
Prg4 作为 TMJ 椎间盘退变新疗法的评估
  • 批准号:
    10525000
  • 财政年份:
    2022
  • 资助金额:
    $ 51.85万
  • 项目类别:
Evaluation of Prg4 as a New Therapy for TMJ Disc Degeneration
Prg4 作为 TMJ 椎间盘退变新疗法的评估
  • 批准号:
    10677033
  • 财政年份:
    2022
  • 资助金额:
    $ 51.85万
  • 项目类别:
Mechanical Regulation of Cell Fate and Multi-Scale Function in the Developing Meniscus
半月板发育中细胞命运和多尺度功能的机械调节
  • 批准号:
    9903234
  • 财政年份:
    2019
  • 资助金额:
    $ 51.85万
  • 项目类别:
Mechanical Regulation of Cell Fate and Multi-Scale Function in the Developing Meniscus
半月板发育中细胞命运和多尺度功能的机械调节
  • 批准号:
    10589080
  • 财政年份:
    2019
  • 资助金额:
    $ 51.85万
  • 项目类别:
Mechanical Regulation of Cell Fate and Multi-Scale Function in the Developing Meniscus
半月板发育中细胞命运和多尺度功能的机械调节
  • 批准号:
    9764868
  • 财政年份:
    2019
  • 资助金额:
    $ 51.85万
  • 项目类别:
Mechanisms of TMJ development and long-term function
颞下颌关节发育和长期功能的机制
  • 批准号:
    8887326
  • 财政年份:
    2014
  • 资助金额:
    $ 51.85万
  • 项目类别:
Mechanisms of TMJ development and long-term function
颞下颌关节发育和长期功能的机制
  • 批准号:
    8614830
  • 财政年份:
    2014
  • 资助金额:
    $ 51.85万
  • 项目类别:
Pathogenic Mechanisms in Hereditary Multiple Exostoses Syndrome
遗传性多发性外生骨疣综合征的发病机制
  • 批准号:
    8475565
  • 财政年份:
    2011
  • 资助金额:
    $ 51.85万
  • 项目类别:
Pathogenic Mechanisms in Hereditary Multiple Exostoses Syndrome
遗传性多发性外生骨疣综合征的发病机制
  • 批准号:
    8294622
  • 财政年份:
    2011
  • 资助金额:
    $ 51.85万
  • 项目类别:
Pathogenic Mechanisms in Hereditary Multiple Exostoses Syndrome
遗传性多发性外生骨疣综合征的发病机制
  • 批准号:
    8183318
  • 财政年份:
    2011
  • 资助金额:
    $ 51.85万
  • 项目类别:

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