Transcriptome regulation during mitosis

有丝分裂期间的转录组调控

基本信息

  • 批准号:
    10359186
  • 负责人:
  • 金额:
    $ 33.99万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2017
  • 资助国家:
    美国
  • 起止时间:
    2017-09-01 至 2024-02-29
  • 项目状态:
    已结题

项目摘要

Project Summary Accurate chromosome segregation during mitosis and meiosis is critical for viability and development. Errors in chromosome segregation lead to aneuploidy, which is closely correlated with cancer. In order to ensure accurate chromosome segregation duplicated sister chromatids must be dramatically condensed and individualized upon entry into mitosis. Accurate chromosome distribution during mitosis depends on the interaction of duplicated sister chromatids with the microtubules of the mitotic spindle. Each chromosome contains one centromere that serves as the site for the formation of the kinetochore. At nuclear envelope breakdown, proteins important for kinetochore:microtubule (K:MT) attachment and signaling molecules that monitor K:MT attachment are recruited to the kinetochore. Successful completion of cell division requires the coordinated regulation of centromere/kinetochore assembly, kinetochore:microtubule attachment and chromosome condensation. Decades of work have identified hundreds of proteins that regulate various aspects of mitosis. However, very little is known about regulation of the transcriptome during mitosis. Recent work has demonstrated that remodeling of the transcriptome plays an important role in mitotic regulation. This proposal will study two fundamental aspects of transcriptome remodeling during mitosis. First, during mitosis, the majority of nuclear transcription is blocked, however, centromeres escape transcriptional down-regulation. Surprisingly, very little is known about the mechanism of transcriptional inhibition during mitosis or how disruption of mitotic transcriptional inhibition impacts the fidelity of chromosome segregation. It is also unknown if the process of mitotic transcriptional inhibition contributes to changing gene expression patterns. Second, during interphase hundreds to thousands of RNAs are retained in the nucleus where they bind to chromatin and regulate nuclear organization and gene expression. During mitosis many nuclear RNAs are released from chromatin, yet little is known about the mechanism of RNA removal from chromatin during mitosis. Additionally, it is unknown how disruption of RNA release from chromatin impacts the process of chromosome segregation or gene expression following mitosis. Our work will investigate how the transcriptome is remodeled during mitosis and how this contributes to accurate chromosome segregation.
项目总结

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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Michael Demian Blower其他文献

Michael Demian Blower的其他文献

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{{ truncateString('Michael Demian Blower', 18)}}的其他基金

Analysis of chromatin-RNA interactions during the cell cycle.
细胞周期中染色质-RNA 相互作用的分析。
  • 批准号:
    10338329
  • 财政年份:
    2022
  • 资助金额:
    $ 33.99万
  • 项目类别:
Analysis of chromatin-RNA interactions during the cell cycle.
细胞周期中染色质-RNA 相互作用的分析。
  • 批准号:
    10593100
  • 财政年份:
    2022
  • 资助金额:
    $ 33.99万
  • 项目类别:
Transcriptome regulation during mitosis
有丝分裂期间的转录组调控
  • 批准号:
    9285488
  • 财政年份:
    2017
  • 资助金额:
    $ 33.99万
  • 项目类别:
Transcriptome regulation during mitosis
有丝分裂期间的转录组调控
  • 批准号:
    9884164
  • 财政年份:
    2017
  • 资助金额:
    $ 33.99万
  • 项目类别:
Transcriptome regulation during mitosis
有丝分裂期间的转录组调控
  • 批准号:
    10212833
  • 财政年份:
    2017
  • 资助金额:
    $ 33.99万
  • 项目类别:
Transcriptome regulation during mitosis
有丝分裂期间的转录组调控
  • 批准号:
    10571877
  • 财政年份:
    2017
  • 资助金额:
    $ 33.99万
  • 项目类别:
Transcriptome regulation during mitosis
有丝分裂期间的转录组调控
  • 批准号:
    10252761
  • 财政年份:
    2017
  • 资助金额:
    $ 33.99万
  • 项目类别:
Genome-wide analysis of polyadenylation and translation in Xenopus
非洲爪蟾多聚腺苷酸化和翻译的全基因组分析
  • 批准号:
    8892211
  • 财政年份:
    2014
  • 资助金额:
    $ 33.99万
  • 项目类别:
Genome-wide analysis of polyadenylation and translation in Xenopus
非洲爪蟾多聚腺苷酸化和翻译的全基因组分析
  • 批准号:
    9220834
  • 财政年份:
    2014
  • 资助金额:
    $ 33.99万
  • 项目类别:
Genome-wide analysis of polyadenylation and translation in Xenopus
非洲爪蟾多聚腺苷酸化和翻译的全基因组分析
  • 批准号:
    8742224
  • 财政年份:
    2014
  • 资助金额:
    $ 33.99万
  • 项目类别:

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