Core A: Administration

摘要 本计划项目的行政核心A旨在提供科学的领导，有效地 通信和行政支持结构，以确保所有计划的协调 项目活动。2015年，这份多PI P01提案的四个PI在《自然》杂志上报道 低分割放疗和双检查点阻断对小鼠抗肿瘤T细胞免疫功能的影响 小鼠和患者通过非冗余机制，解释了明显的协同作用。这是最新的 拟议的计划项目寻求深入扩展我们对辐射相交的知识 以及癌症的免疫疗法。拟议的方案有三个项目和三个核心， 多个学科的高级领导与更初级的教职调查人员一起工作的平衡 一队。我们利用了庞大而高效的行政人员和集中的 宾夕法尼亚大学艾布拉姆森癌症中心(ACC)的研究机构 实现我们的目标。来自ACC和宾夕法尼亚大学的强有力的机构承诺帮助奠定了 为我们的科学和翻译成就奠定了基础。由政府提供的基本服务 核心A包括：为每个项目和核心中的所有调查员提供行政支助；财政 管理和监督计划项目的所有组成部分；以及组织和 所有计划项目会议和活动的沟通。这个核心的总体目标是有效的 以及对P01的高效领导。核心董事、联席董事和行政人员的角色 是在促进交流的同时促进科技互动。为了 为了实现这一目标，核心确定了三个目标：(1)建立和维持一个 为所有计划项目活动提供支持和管理的行政结构，(2) 营造一种环境，以最大限度地提高计划项目调查员和 其他P01和NCI倡议之间的关系，以及(3)确保遵守所有机构、政府 和NCI的法规和政策。

SUMMARY The Administrative Core A of this Program Project is designed to provide scientific leadership, effective communication and an administrative support structure to ensure the coordination of all Program Project activities. In 2015, the four PIs of this multiple PI P01 proposal reported in Nature that hypofractionated radiation and dual checkpoint blockade activated anti-tumor T cell immunity in both mice and patients via non-redundant mechanisms, explaining the apparent synergy. This newly proposed Program Project seeks to deeply extend our knowledge regarding the intersection of radiation and immunotherapy of cancer. The proposed program has three projects and three cores, with a balance of senior leaders in multiple disciplines working alongside more junior faculty investigators as a team. We have taken advantage of the large and efficient administrative staff and the centralized research organizations at the Abramson Cancer Center (ACC) of the University of Pennsylvania to achieve our objectives. Strong institutional commitment from the ACC and Penn has helped lay the foundation for our scientific and translational achievements. The essential services provided by the Core A include: administrative support for all of the investigators in each project and core; fiscal management and oversight for all components of the Program Project; and organization and communication of all Program Project meetings and activities. The overall goal of this Core is effective and efficient leadership of the P01. The roles of the Core Director, Co-Director and administrative staff are to facilitate communication while stimulating scientific and technological interactions. In order to achieve this goal, the Core has established three objectives: (1) Establish and maintain an administrative structure to provide support for and management of all Program Project activities, (2) Foster an environment to maximize collaborative research among Program Project investigators and between other P01 and NCI initiatives, and (3) Ensure compliance with all institutional, governmental and NCI regulations and policies.