Core A: Administration

核心A：管理

• 批准号: 10005186
• 负责人: ROBERT H VONDERHEIDE
• 金额: $ 6.77万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-08-01 至 2023-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10005186
• 关键词: Abramson Cancer Center at the University of Pennsylvania; Achievement; Cancer Center; Communication; Discipline; Ensure; Environment; Equilibrium; Faculty; Fostering; Foundations; Goals; Government; Immunity; Immunotherapy; Knowledge; Leadership; Malignant Neoplasms; Mus; Nature; Patients; Policies; Radiation; Regulation; Reporting; Research; Research Personnel; Role; Services; Structure; T-Lymphocyte; cancer immunotherapy; design; immune checkpoint blockade; meetings; programs; synergism; tumor

SUMMARY The Administrative Core A of this Program Project is designed to provide scientific leadership, effective communication and an administrative support structure to ensure the coordination of all Program Project activities. In 2015, the four PIs of this multiple PI P01 proposal reported in Nature that hypofractionated radiation and dual checkpoint blockade activated anti-tumor T cell immunity in both mice and patients via non-redundant mechanisms, explaining the apparent synergy. This newly proposed Program Project seeks to deeply extend our knowledge regarding the intersection of radiation and immunotherapy of cancer. The proposed program has three projects and three cores, with a balance of senior leaders in multiple disciplines working alongside more junior faculty investigators as a team. We have taken advantage of the large and efficient administrative staff and the centralized research organizations at the Abramson Cancer Center (ACC) of the University of Pennsylvania to achieve our objectives. Strong institutional commitment from the ACC and Penn has helped lay the foundation for our scientific and translational achievements. The essential services provided by the Core A include: administrative support for all of the investigators in each project and core; fiscal management and oversight for all components of the Program Project; and organization and communication of all Program Project meetings and activities. The overall goal of this Core is effective and efficient leadership of the P01. The roles of the Core Director, Co-Director and administrative staff are to facilitate communication while stimulating scientific and technological interactions. In order to achieve this goal, the Core has established three objectives: (1) Establish and maintain an administrative structure to provide support for and management of all Program Project activities, (2) Foster an environment to maximize collaborative research among Program Project investigators and between other P01 and NCI initiatives, and (3) Ensure compliance with all institutional, governmental and NCI regulations and policies.

概括 该计划项目的行政核心 A 旨在提供科学领导、有效 沟通和行政支持结构，以确保所有计划的协调 项目活动。 2015年，这项多项PI P01提案的四位PI在《自然》杂志上报道称： 大分割放疗和双重检查点阻断均激活了抗肿瘤 T 细胞免疫 小鼠和患者通过非冗余机制进行研究，解释了明显的协同作用。这个新 拟议的计划项目旨在深入扩展我们关于辐射交叉点的知识 和癌症的免疫治疗。拟议的计划有三个项目和三个核心，其中 平衡多个学科的高级领导与更多初级教员研究人员一起工作 团队。我们利用了庞大而高效的行政人员和集中的 宾夕法尼亚大学艾布拉姆森癌症中心 (ACC) 的研究组织 实现我们的目标。 ACC 和宾夕法尼亚大学强有力的机构承诺帮助奠定了 我们的科学和转化成就的基础。所提供的基本服务 核心 A 包括：为每个项目和核心的所有研究人员提供行政支持；财 管理和监督计划项目的所有组成部分；和组织和 所有计划项目会议和活动的沟通。该核心的总体目标是有效的 和 P01 的高效领导。核心董事、联席董事和行政人员的角色 旨在促进交流，同时促进科学和技术互动。为了 为了实现这一目标，核心确立了三个目标：（1）建立并维持 为所有计划项目活动提供支持和管理的行政结构，(2) 营造一个环境，以最大限度地提高计划项目研究人员和 其他 P01 和 NCI 举措之间的关系，以及 (3) 确保遵守所有机构、政府 以及 NCI 法规和政策。