Adult Cognitive and Neurobiological Indicators of Aging: Impact of Adversity and Social Support

成人衰老的认知和神经生物学指标：逆境和社会支持的影响

• 批准号: 10365348
• 负责人: ELIZABETH A CARLSON
• 金额: $ 61.94万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-15 至 2027-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10365348
• 关键词: Address; Adult; Adverse event; Age; Aging; Animals; Behavioral; Behavioral Research; Biological; Birth; Brain; Buffers; Chronic; Cognition; Cognitive; Cohort Studies; DNA Methylation; Data; Data Analytics; Development; Emotions; Epigenetic Process; Event; Exposure to; Foundations; Genetic; Growth; Hippocampus (Brain); Human; Individual; Intercept; Intervention; Investigation; Length; Life; Life Cycle Stages; Link; Longitudinal Studies; Measures; Methodology; Minnesota; Modeling; Neurobiology; Neurophysiology - biologic function; Outcome; Participant; Policies; Prefrontal Cortex; Prevention; Prevention approach; Process; Public Health; Research; Retrospective Studies; Risk; Role; Sampling; Sensorimotor functions; Social support; Structure; Techniques; Testing; Variant; Work; age related; base; biobehavior; biological systems; brain health; caregiving; cognitive function; connectome; cost; design; early experience; early life adversity; epigenetic marker; epigenetic variation; experience; longitudinal dataset; neurotoxicity; novel; physical conditioning; preventive intervention; prospective; psychosocial; public health relevance; social relationships; telomere

Project Summary/Abstract Using a unique longitudinal data set and linear growth modeling analytic techniques, the proposed research will examine relations between early and life course trajectories of adversity and adult biobehavioral markers of aging. Animal and human studies suggest that early exposure to adversity may negatively impact developing biological systems altering long term structural and functional trajectories, and accelerating aging processes. The proposed research will examine this neurotoxicity hypothesis in relation to brain neurobiology (structure, function, connectivity) and related cognitive and epigenetic markers sensitive to adversity and aging. The research will also examine the role of protective social relationships (especially positive early caregiving) in moderating the adversity-related effects. Based in the Minnesota Longitudinal Study of Risk and Adaptation (Sroufe et al., 2005) and drawing on methodology from the Human Connectome Project in Aging (HCP-A; Bookheimer et al., 2019), the study addresses significant gaps in both neurobiological and behavioral investigations of the origins of adult aging processes and the effects of adversity on development. Unlike concurrent and retrospective studies of risk and protective influences on aging, the proposed study employs a prospective multilevel design with a sample of individuals assessed from birth to middle adulthood. The proposed assessments of neurobiological and cognitive functioning will contribute to an understanding of the impact of exposure to adversity on adult brain health (structure, function, connectivity) and age-related cognition. Specifically, we will examine the timing and chronicity (onset and trajectory) of adversity in relation to adult outcomes. Genetic data will permit analyses of associations between adversity, epigenetic variation (i.e., telomere length, DNA methylation age), and concurrent neural and cognitive functioning. The proposed work will address critical research, policy, and practice questions regarding the effects of adverse experience on the human brain, the cognitive and biological correlates of neurobiological change, and the potential moderating influence of early caregiving experience on these relations, generating testable research hypotheses and contributing to the development of targeted prevention and intervention efforts.

项目摘要/摘要 使用独特的纵向数据集和线性增长建模分析技术， 拟议的研究将研究早期和生命过程之间的关系 和成人衰老的生物行为标记。动物和人类研究表明 暴露于逆境可能会对发展长期改变生物系统的发展产生负面影响 结构和功能轨迹，以及加速衰老过程。拟议的研究 将检查与脑神经生物学有关的这种神经毒性假设（结构，功能， 连通性）以及对逆境和衰老敏感的相关认知和表观遗传标记。这 研究还将研究保护性社会关系的作用（尤其是积极的早期 护理）调节与逆境相关的效果。 基于明尼苏达州的风险和适应纵向研究（Sroufe等，2005）和 利用衰老的人类连接符项目的方法（HCP-A； Bookheimer et Al。，2019年），该研究解决了神经生物学和行为的显着差距 研究成人衰老过程的起源以及逆境对 发展。与并发和回顾性研究以及对风险和保护性影响的研究 衰老，拟议的研究采用了预期的多级设计，并用一个个体样本 从出生到成年中的评估。拟议的神经生物学评估和 认知功能将有助于理解暴露于逆境的影响 关于成人大脑健康（结构，功能，连通性）和与年龄有关的认知。具体来说， 我们将研究与成人有关的逆境的时机和慢性（发作和轨迹） 结果。遗传数据将允许分析逆境，表观遗传学之间的关联 变异（即端粒长度，DNA甲基化年龄）和并发神经和认知 功能。拟议的工作将解决关键研究，政策和实践问题 关于不利经验对人脑，认知和 神经生物学变化的生物学相关性，以及潜在的调节作用 这些关系的早期护理经验，产生可检验的研究假设 并为有针对性的预防和干预工作做出贡献。