Neural Mechanisms of Visual Crowding

视觉拥挤的神经机制

基本信息

  • 批准号:
    10365136
  • 负责人:
  • 金额:
    $ 41.76万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2022
  • 资助国家:
    美国
  • 起止时间:
    2022-01-01 至 2026-12-31
  • 项目状态:
    未结题

项目摘要

Project Summary Visual perception is an active process of information selection. Two critical components of this selection process are the mechanisms of spatial attention and saccadic eye-movements. Attention allows us to deploy limited neural resources for privileged processing of salient stimuli; saccades allow us to bring stimuli of interest to the center of gaze for detailed inspection. The dynamic interplay of attention and saccades is particularly prominent in peripheral vision where inappropriate integration of contextual information has been proposed as one of the underlying mechanisms of visual crowding. Visual crowding is the inability to identify stimuli amidst clutter and is a fundamental bottleneck to object recognition in peripheral vision. It is particularly detrimental in the case of patients with central vision loss such as macular degeneration (MD), since these individuals rely on a peripheral retinal locus (PRL) for object recognition tasks. Crowding zones, the area in visual space over which distractors affect target identification, are markedly elongated along the radial axis aligned with the fovea in normal vision. Crowding zones undergo systematic reorganization in MD patients with an elongated component along the radial PRL axis. Despite decades of research, the neural underpinnings of crowding and that of the elongated shape of crowding zones remain unknown. In this proposal we will bridge these knowledge gaps in the context of the activity of six neural sub-populations – two cell classes (inhibitory and excitatory neurons) in three layers (superficial, input, deep) – that are fundamental components of the sensory laminar cortical circuit. Our broad hypothesis is that sub-population specific activity dynamics form the substrate for contextual interactions underlying crowding and for the formation and re-organization of crowding zones. We propose to answer several key questions regarding this hypothesis. What are the laminar mechanisms of contextual modulation in crowding zones (Aim 1)? What the spatio-temporal dynamics of peri- saccadic activity in the laminar cortical circuit (Aim 2)? What are the neural mechanisms of crowding zone reorganization following central vision zone (Aim 3)? We will achieve these aims using high-density laminar neural recordings in visual area V4 of awake non-human primates. V4, a critical node in the object recognition pathway, that also receives strong attention related and oculomotor signals, is ideally suited for these investigations. The results of these investigations will uncover the neural mechanisms of crowding, provide a broad framework for visual form processing in the periphery and inform possible future intervention studies in central vision loss.
项目总结

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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Anirvan S. Nandy其他文献

Saccade-distorted image statistics explain target-flanker and flanker-flanker interactions in crowding
扫视扭曲图像统计解释了拥挤中的目标-侧翼和侧翼-侧翼相互作用
  • DOI:
  • 发表时间:
    2010
  • 期刊:
  • 影响因子:
    0
  • 作者:
    B. Tjan;Anirvan S. Nandy
  • 通讯作者:
    Anirvan S. Nandy
Higher dopamine D1 receptor expression in prefrontal parvalbumin neurons underlies higher distractibility in marmosets versus macaques
在绒猴中前额叶小白蛋白神经元中较高的多巴胺 D1 受体表达是其相对于猕猴更高的分心能力的基础
  • DOI:
    10.1038/s42003-025-08297-0
  • 发表时间:
    2025-07-01
  • 期刊:
  • 影响因子:
    5.100
  • 作者:
    Mary Kate P. Joyce;Tsvetoslav G. Ivanov;Fenna M. Krienen;Jude F. Mitchell;Shaojie Ma;Wataru Inoue;Anirvan S. Nandy;Dibyadeep Datta;Alvaro Duque;Jon I. Arellano;Rahul Gupta;Guillermo Gonzalez-Burgos;David A. Lewis;Nenad Sestan;Steven A. McCarroll;Julio Martinez-Trujillo;Seán Froudist-Walsh;Amy F. T. Arnsten
  • 通讯作者:
    Amy F. T. Arnsten
Spatial context non-uniformly modulates inter-laminar information flow in the primary visual cortex
空间上下文非均匀地调节主要视觉皮层中的层间信息流
  • DOI:
    10.1016/j.neuron.2024.09.021
  • 发表时间:
    2024-12-18
  • 期刊:
  • 影响因子:
    15.000
  • 作者:
    Xize Xu;Mitchell P. Morton;Sachira Denagamage;Nyomi V. Hudson;Anirvan S. Nandy;Monika P. Jadi
  • 通讯作者:
    Monika P. Jadi
State-dependent modulation of dependencies in a laminar cortical circuit
层状皮质回路中依赖性的状态相关调制
  • DOI:
  • 发表时间:
    2023
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Anirban Das;Alec G. Sheffield;Anirvan S. Nandy;M. Jadi
  • 通讯作者:
    M. Jadi
Population Statistics
人口统计
  • DOI:
  • 发表时间:
    1937
  • 期刊:
  • 影响因子:
    64.8
  • 作者:
    Anirvan S. Nandy;T. Sharpee;J. Reynolds;Jude F. Mitchell
  • 通讯作者:
    Jude F. Mitchell

Anirvan S. Nandy的其他文献

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{{ truncateString('Anirvan S. Nandy', 18)}}的其他基金

Neural Mechanisms of Visual Crowding
视觉拥挤的神经机制
  • 批准号:
    10540782
  • 财政年份:
    2022
  • 资助金额:
    $ 41.76万
  • 项目类别:

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