Administrative core

项目概要（核心1、行政核心、Sil） 我们的目标是建立一个充满活力和富有成效的球孢子菌病合作研究中心 （CCRC），题目为Molecules and Pathways at the Coccidioides Host-Pathogen Interface。我们带来 由基础科学家、临床研究人员和技术专家组成的骨干队伍将研究发病机制， 和宿主反应的细微差别在模型系统中，在慢性球孢子菌病， 球孢子菌性脑膜炎总之，我们将提供的见解，将弥合差距，诊断，治疗， 以及球孢子菌病的潜在疫苗设计。 行政核心是整合每个项目成果的关键， 组，并通过指导发展的球孢子菌病领域招募初级研究人员 研究计划倡议。我们将提供科学的，组织的和行政的领导， 财务监督。科学进步将通过每季度对数据进行广泛审查来促进和评估。 所有CCRC成员参加的会议。此外，我们还将每年举行一次全体会议， 参与者所有与每个项目和核心相关的研究人员将评估每个项目和核心的科学进展。 小组和提供建设性的反馈，这将支持受训者的发展，同时促进科学卓越。 此外，如果该CCRC获得资助，我们将建立一个外部科学咨询委员会（SAB）， 基础真菌学、微生物学、真菌免疫学、传染病和宿主反应方面的专家。因此我们 我期待这一提案的所有要素之间产生独特的协同作用，使我们能够支持经验丰富的 初级研究人员在球孢子菌领域，并作出新的和关键的贡献，诊断和 防治球孢子菌病的治疗策略。

Project Summary (Core 1, Administrative Core, Sil) Our goal is to establish a vibrant and productive Coccidioidomycosis Collaboration Research Center (CCRC) entitled Molecules and Pathways at the Coccidioides Host-Pathogen Interface. We are bringing together a cadre of basic scientists, clinical investigators, and technologists who will interrogate the pathogenesis of Coccidioides and the nuances of the host response in model systems, in chronic coccidiomycosis, and in coccidioidal meningitis. Taken together, we will provide insights that will bridge gaps in diagnostics, therapeutics, and potentially vaccine design for coccidioidomycosis. The Administrative Core is key to integrating the findings of each project, fostering synergy between our groups, and recruiting junior investigators to the coccidioidomycosis field via the mentored Developmental Research Program initiative. We will provide scientific, organizational, and administrative leadership as well as financial oversight. Scientific progress will be fostered and evaluated by extensive review of data at quarterly meetings attended by all of the CCRC members. In addition, we will have an annual in-person meeting for all participants. All investigators affiliated with each project and core will evaluate the scientific progress of each group and give constructive feedback that will support trainee development while fostering scientific excellence. Additionally, if this CCRC is funded, we will establish an external scientific advisory board (SAB) comprised of experts in basic mycology, microbiology, immunology of fungi, infectious disease, and host response. Thus we expect a unique synergy between all elements of this proposal that will allow us to support both seasoned and junior investigators in the Coccidioides field and make novel and critical contributions to diagnostic and therapeutic strategies to combat coccidioidomycosis.