Clinical and Diagnostics Core

摘要 核心3：临床和诊断核心联席董事：(Thompson And Kenyon) Core 3将提供基础设施和分析，以支持跨学科发现和翻译研究 本申请项目中提出的目标。核心3资源将支持调查 球孢子菌病和治疗中病谱的免疫和代谢相关性 成果(项目3)。通过采集脑脊液和外周血液样本，Core 3将提供样本 用于研究播散性球虫的宿主转录反应(项目2)。酷睿3将支持 评价项目1和2中确定的球虫抗原和宿主生物标记物的诊断潜力 在项目2中确定。 核心3的具体目标如下：(1)开发球虫患者样本库， 通过支持发现和翻译研究的独特数据库链接到临床患者信息 球孢子菌病。(2)利用资源，增加球孢子菌病研究合作 可通过加州大学戴维斯临床和翻译科学中心(CTSC)获得，西海岸代谢组学 中心(WCMC)和其他技术核心。 总而言之，核心3将在支持项目1、2和3的研究调查方面发挥关键作用 通过提供来自球虫感染患者的明确的临床样本。与 CTSC，核心3将提供球孢子菌病的临床(已确认)数据和血清学结果 诊断实验室。因此，Core 3将成为包括血清在内的临床样本的重要来源， 脑脊液和外周血单核细胞样本。此外，核心3将评估球虫抗原的诊断潜力 项目1和2中确定的生物标志物和项目2中确定的宿主生物标记物。如果这些候选对象显示出希望， 将通过诊断实验室进行进一步的研究，以便将这些试剂推进到 诊所。

Summary Core 3: Clinical and Diagnostics Core Co-Directors: (Thompson and Kenyon) The Core 3 will provide infrastructure and assays to support interdisciplinary discovery and translational research objectives proposed in the Projects of this application. The Core 3 resources will support the investigation of immune and metabolic correlates of the spectrum of disease encountered in coccidioidomycosis and treatment outcomes (Project 3). Through the collection of CSF and peripheral blood samples, Core 3 will provide samples for investigating host transcriptomic response in disseminated Coccidioides (Project 2). Core 3 will support an evaluation of the diagnostic potential of Coccidioides antigens identified in Projects 1 and 2 and host biomarkers identified in Project 2. The Specific Aims of the Core 3 are the following: (1) To develop Coccidioides patient sample repositories that link to clinical patient information through unique databases that support discovery and translational research on coccidioidomycosis. (2) To increase coccidioidomycosis research collaborations by leveraging resources available through the UC Davis Clinical and Translational Science Center (CTSC), West Coast Metabolomics Center (WCMC) and other technology cores. In summary, Core 3 will play a critical role in supporting the research investigations for the Projects 1, 2 and 3 by providing well defined clinical samples from patients with Coccidioides infection. In collaboration with the CTSC, Core 3 will provide clinical (deidentified) data and serological findings from the Coccidioidomycosis Diagnostic laboratory. Thus, Core 3 will serve as an important source of the clinical samples including serum, CSF and PBMC samples. Additionally, Core 3 will evaluate the diagnostic potential of Coccidioides antigens identified in the Projects 1 and 2 and host biomarkers identified in Project 2. If these candidates show promise, further studies will be performed through the Diagnostic laboratory so that these reagents can be advanced to the clinic.