Prediction of Alcohol Use Disorder and PTSD After Trauma in Adolescents
青少年创伤后酒精使用障碍和创伤后应激障碍 (PTSD) 的预测
基本信息
- 批准号:10367692
- 负责人:
- 金额:$ 94.79万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-09-05 至 2027-06-30
- 项目状态:未结题
- 来源:
- 关键词:AccelerationAccident and Emergency departmentAcousticsAcuteAddressAdolescenceAdolescentAdultAgeAgingAlcohol dependenceAnti-Inflammatory AgentsAutonomic nervous systemBiologicalBiological MarkersBloodBrainCessation of lifeChildClinicClinics and HospitalsCognitiveCollectionCross-Sectional StudiesDNA MethylationDSM-VDataData SetDevelopmentDiagnosisDiseaseEarly InterventionElectrocardiogramElectromyographyEmotionalEnrollmentEpigenetic ProcessExhibitsExposure toFamily StudyGalvanic Skin ResponseGenetic RiskGenomicsHeart RateHeritabilityHospitalsIndividualInflammationInflammatoryInflammatory ResponseInjuryInterferon Type IILongitudinal StudiesMachine LearningMeasurementMeasuresMedicalMedical centerModelingNeuraxisNeurobiologyOutcomePathogenesisPathway interactionsPatientsPhenotypePhysiologicalPost-Traumatic Stress DisordersProspective StudiesPsychophysiologyRNAReflex actionResearchRiskRisk FactorsRoleSamplingSiteStartle ReactionStatistical ModelsStressTNF geneTechniquesTexasTimeTissuesTraumaTwin StudiesUniversitiesUntranslated RNAValidationWorkalcohol riskalcohol use disorderaustinbasebiosignaturecohortcomorbiditycytokinedesigndisorder riskdrinking onsetearly onsetepidemiology studyepigenomicsfollow-upgenomic predictorsheart rate variabilityhigh riskindexingmolecular markernovelpolygenic risk scorepost-traumapredictive markerpredictive modelingpredictive toolsprospectiveresponsesexual violencesocioeconomicsstatisticstooltranscriptomicstrauma centerstrauma exposure
项目摘要
PROJECT SUMMARY
Acute trauma, defined by the DSM-5 criterion A for the diagnosis of post-traumatic stress disorder (PTSD) as
exposure to actual or threatened death, serious injury or sexual violence, is associated with an increase in the
development of both Alcohol Use Disorder (AUD) and PTSD. It is well established that patients with PTSD
have a markedly increased risk for AUD. Furthermore, understanding risk for AUD during development,
particularly in adolescents is critical, as early onset drinking is one of the highest risk factors for lifetime alcohol
addiction. This current proposal seeks to further explore the relationship of AUD and PTSD in adolescents
exposed to acute trauma by focusing on biological predictors of AUD and/or PTSD development. In brief, 500
adolescents will be studied in the immediate aftermath of trauma in emergency departments, hospital clinics or
psychiatric settings in Austin, Texas (Dell Children’s Medical Center) and Galveston, Texas (University of
Texas Medical Branch (UTMB) affiliated hospitals). Using emerging statistical techniques and machine
learning-based analytics, we will identify predictive: 1. Genomic and epigenomic, 2. Inflammatory, and 3.
Psychophysiological biomarkers of risk for AUD and PTSD. Although several risk factors have been identified
in adults for the development of these two disorders, relatively little data is available in adolescents. Family and
twin studies have provided estimates of genetic risk for AUD and PTSD of 50% and 30-40%, respectively. We
will utilize the latest AUD and PTSD polygenic risk factor scores for these disorders, together with epigenomic
analysis. Previous work has implicated alterations in inflammatory response in both AUD and PTSD and we
will assess this in the immediate aftermath of the trauma. Finally, measures of autonomic nervous system
(including skin conductance response [SCR], heart rate and heart rate variability [HRV] via electrocardiography
[ECG]) and central nervous system (acoustic startle response assessed via electromyography [EMG])
reactivity will be assessed immediately after post-trauma medical clearance. Using state of the art statistical
modeling, we will identify biological predictors of AUD and PTSD and their interrelationship. These data will be
used to develop novel tools to predict which adolescents exposed to trauma will likely develop AUD and/or
PTSD, allowing for early intervention at this critical time in development.
项目摘要
急性创伤,根据DSM-5创伤后应激障碍(PTSD)诊断标准A定义为:
暴露于实际或威胁的死亡、严重伤害或性暴力,
酒精使用障碍(AUD)和PTSD的发展。创伤后应激障碍患者
患AUD的风险显著增加。此外,了解开发过程中AUD的风险,
特别是在青少年中是至关重要的,因为早发性饮酒是终生饮酒的最高风险因素之一。
成瘾本研究旨在进一步探讨青少年AUD与PTSD的关系
通过关注AUD和/或PTSD发展的生物学预测因素,暴露于急性创伤。简而言之,
青少年将在急诊室、医院诊所或其他医疗机构接受创伤后立即进行研究。
德克萨斯州奥斯汀(戴尔儿童医疗中心)和德克萨斯州加尔维斯顿(德克萨斯大学)的精神病机构
德克萨斯州医疗分支(UTMB)附属医院)。利用新兴的统计技术和机器
基于学习的分析,我们将确定预测:1.基因组学和表观基因组学,2。炎症,3。
AUD和PTSD风险的心理生理学生物标志物尽管已经确定了几个风险因素,
在成年人中,这两种疾病的发展,在青少年中的数据相对较少。家庭和
双胞胎研究估计AUD和PTSD的遗传风险分别为50%和30- 40%。我们
将利用这些疾病的最新AUD和PTSD多基因风险因素评分,以及表观基因组
分析.以前的研究表明,AUD和PTSD的炎症反应发生了改变,我们认为,
将在创伤发生后立即评估这一点。最后,自主神经系统的测量
(包括通过心电图的皮肤电导反应[SCR]、心率和心率变异性[HRV]
[心电图])和中枢神经系统(通过肌电图[EMG]评估的声音惊吓反应)
将在创伤后体检合格后立即评估反应性。使用最先进的统计技术
模型,我们将确定AUD和PTSD的生物学预测因子及其相互关系。这些数据将
用于开发新的工具,以预测哪些青少年暴露于创伤可能会发展AUD和/或
创伤后应激障碍,允许在这个发展的关键时刻进行早期干预。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
CHARLES B NEMEROFF其他文献
CHARLES B NEMEROFF的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('CHARLES B NEMEROFF', 18)}}的其他基金
Prediction of Alcohol Use Disorder and PTSD After Trauma in Adolescents
青少年创伤后酒精使用障碍和创伤后应激障碍 (PTSD) 的预测
- 批准号:
10693806 - 财政年份:2022
- 资助金额:
$ 94.79万 - 项目类别:
1/3 Understanding PTSD through Postmortem Targeted Brain Multi-omics
1/3 通过死后靶向脑多组学了解 PTSD
- 批准号:
9815771 - 财政年份:2018
- 资助金额:
$ 94.79万 - 项目类别:
1/3 Understanding PTSD through Postmortem Targeted Brain Multi-omics
1/3 通过死后靶向脑多组学了解 PTSD
- 批准号:
9924647 - 财政年份:2018
- 资助金额:
$ 94.79万 - 项目类别:
1/3 Understanding PTSD through Postmortem Targeted Brain Multi-omics
1/3 通过死后靶向脑多组学了解 PTSD
- 批准号:
10159964 - 财政年份:2018
- 资助金额:
$ 94.79万 - 项目类别:
1/3 Understanding PTSD through Postmortem Targeted Brain Multi-omics
1/3 通过死后靶向脑多组学了解 PTSD
- 批准号:
10405109 - 财政年份:2018
- 资助金额:
$ 94.79万 - 项目类别:
Stem Cell Therapy, Inflammation and Treatment Response inAlcoholism-Depression Comorbidity
干细胞疗法、酒精中毒抑郁症合并症的炎症和治疗反应
- 批准号:
9380069 - 财政年份:2017
- 资助金额:
$ 94.79万 - 项目类别:
1 of 2 - Prospective Determination of Psychobiological Risk Factors for PTSD
1 of 2 - PTSD 心理生物学风险因素的前瞻性确定
- 批准号:
8290799 - 财政年份:2012
- 资助金额:
$ 94.79万 - 项目类别:
1 of 2 - Prospective Determination of Psychobiological Risk Factors for PTSD
1 of 2 - PTSD 心理生物学风险因素的前瞻性确定
- 批准号:
8659508 - 财政年份:2012
- 资助金额:
$ 94.79万 - 项目类别:
1 of 2 - Prospective Determination of Psychobiological Risk Factors for PTSD
1 of 2 - PTSD 心理生物学风险因素的前瞻性确定
- 批准号:
8470246 - 财政年份:2012
- 资助金额:
$ 94.79万 - 项目类别:
EARLY LIFE STRESS IN NON HUMAN PRIMATES AND HUMANS
非人类灵长类动物和人类的早期生活压力
- 批准号:
7958154 - 财政年份:2009
- 资助金额:
$ 94.79万 - 项目类别: