Prediction of Alcohol Use Disorder and PTSD After Trauma in Adolescents

青少年创伤后酒精使用障碍和创伤后应激障碍 (PTSD) 的预测

基本信息

  • 批准号:
    10693806
  • 负责人:
  • 金额:
    $ 85.42万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2022
  • 资助国家:
    美国
  • 起止时间:
    2022-09-05 至 2027-06-30
  • 项目状态:
    未结题

项目摘要

PROJECT SUMMARY Acute trauma, defined by the DSM-5 criterion A for the diagnosis of post-traumatic stress disorder (PTSD) as exposure to actual or threatened death, serious injury or sexual violence, is associated with an increase in the development of both Alcohol Use Disorder (AUD) and PTSD. It is well established that patients with PTSD have a markedly increased risk for AUD. Furthermore, understanding risk for AUD during development, particularly in adolescents is critical, as early onset drinking is one of the highest risk factors for lifetime alcohol addiction. This current proposal seeks to further explore the relationship of AUD and PTSD in adolescents exposed to acute trauma by focusing on biological predictors of AUD and/or PTSD development. In brief, 500 adolescents will be studied in the immediate aftermath of trauma in emergency departments, hospital clinics or psychiatric settings in Austin, Texas (Dell Children’s Medical Center) and Galveston, Texas (University of Texas Medical Branch (UTMB) affiliated hospitals). Using emerging statistical techniques and machine learning-based analytics, we will identify predictive: 1. Genomic and epigenomic, 2. Inflammatory, and 3. Psychophysiological biomarkers of risk for AUD and PTSD. Although several risk factors have been identified in adults for the development of these two disorders, relatively little data is available in adolescents. Family and twin studies have provided estimates of genetic risk for AUD and PTSD of 50% and 30-40%, respectively. We will utilize the latest AUD and PTSD polygenic risk factor scores for these disorders, together with epigenomic analysis. Previous work has implicated alterations in inflammatory response in both AUD and PTSD and we will assess this in the immediate aftermath of the trauma. Finally, measures of autonomic nervous system (including skin conductance response [SCR], heart rate and heart rate variability [HRV] via electrocardiography [ECG]) and central nervous system (acoustic startle response assessed via electromyography [EMG]) reactivity will be assessed immediately after post-trauma medical clearance. Using state of the art statistical modeling, we will identify biological predictors of AUD and PTSD and their interrelationship. These data will be used to develop novel tools to predict which adolescents exposed to trauma will likely develop AUD and/or PTSD, allowing for early intervention at this critical time in development.
项目总结

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

CHARLES B NEMEROFF其他文献

CHARLES B NEMEROFF的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('CHARLES B NEMEROFF', 18)}}的其他基金

Prediction of Alcohol Use Disorder and PTSD After Trauma in Adolescents
青少年创伤后酒精使用障碍和创伤后应激障碍 (PTSD) 的预测
  • 批准号:
    10367692
  • 财政年份:
    2022
  • 资助金额:
    $ 85.42万
  • 项目类别:
1/3 Understanding PTSD through Postmortem Targeted Brain Multi-omics
1/3 通过死后靶向脑多组学了解 PTSD
  • 批准号:
    9815771
  • 财政年份:
    2018
  • 资助金额:
    $ 85.42万
  • 项目类别:
1/3 Understanding PTSD through Postmortem Targeted Brain Multi-omics
1/3 通过死后靶向脑多组学了解 PTSD
  • 批准号:
    9924647
  • 财政年份:
    2018
  • 资助金额:
    $ 85.42万
  • 项目类别:
1/3 Understanding PTSD through Postmortem Targeted Brain Multi-omics
1/3 通过死后靶向脑多组学了解 PTSD
  • 批准号:
    10159964
  • 财政年份:
    2018
  • 资助金额:
    $ 85.42万
  • 项目类别:
1/3 Understanding PTSD through Postmortem Targeted Brain Multi-omics
1/3 通过死后靶向脑多组学了解 PTSD
  • 批准号:
    10405109
  • 财政年份:
    2018
  • 资助金额:
    $ 85.42万
  • 项目类别:
Stem Cell Therapy, Inflammation and Treatment Response inAlcoholism-Depression Comorbidity
干细胞疗法、酒精中毒抑郁症合并症的炎症和治疗反应
  • 批准号:
    9380069
  • 财政年份:
    2017
  • 资助金额:
    $ 85.42万
  • 项目类别:
1 of 2 - Prospective Determination of Psychobiological Risk Factors for PTSD
1 of 2 - PTSD 心理生物学风险因素的前瞻性确定
  • 批准号:
    8290799
  • 财政年份:
    2012
  • 资助金额:
    $ 85.42万
  • 项目类别:
1 of 2 - Prospective Determination of Psychobiological Risk Factors for PTSD
1 of 2 - PTSD 心理生物学风险因素的前瞻性确定
  • 批准号:
    8659508
  • 财政年份:
    2012
  • 资助金额:
    $ 85.42万
  • 项目类别:
1 of 2 - Prospective Determination of Psychobiological Risk Factors for PTSD
1 of 2 - PTSD 心理生物学风险因素的前瞻性确定
  • 批准号:
    8470246
  • 财政年份:
    2012
  • 资助金额:
    $ 85.42万
  • 项目类别:
EARLY LIFE STRESS IN NON HUMAN PRIMATES AND HUMANS
非人类灵长类动物和人类的早期生活压力
  • 批准号:
    7958154
  • 财政年份:
    2009
  • 资助金额:
    $ 85.42万
  • 项目类别:
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了