Prenatal and lifetime exposure to pesticides and particulate matter and respiratory health in young adults from the CHAMACOS birth

CHAMACOS 出生后年轻人的产前和终生接触农药和颗粒物以及呼吸系统健康

• 批准号: 10367205
• 负责人: Robert Gunier
• 金额: $ 58.71万
• 依托单位: UNIVERSITY OF CALIFORNIA BERKELEY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-02-10 至 2026-11-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10367205
• 关键词: 21 year old; 7 year old; Absenteeism; Address; Adolescence; Adult; Age; Age-Years; Agriculture; Air; Air Pollutants; Air Pollution; Airway Disease; Asthma; Biological; Biological Markers; Birth; California; Cells; Child; Childhood; Childhood Asthma; Cohort Studies; Complex; Cross-Sectional Studies; DNA; DNA Methylation; Data; Data Reporting; Disease; Environment; Environmental Exposure; Epigenetic Process; Epithelial Cells; Ethylenes; Etiology; Exposure to; Family; Future; Genes; Goals; Grant; Growth; Hypersensitivity; Individual; Industrial fungicide; Inflammation; Joints; Life; Link; Longitudinal Studies; Measures; Methylation; Mexican Americans; Morbidity - disease rate; Mothers; Nasal Epithelium; Nose; Occupational; Occupational Exposure; Organophosphates; Outcome; Participant; Particulate Matter; Pathway interactions; Persons; Pesticides; Play; Policies; Predisposition; Pregnancy; Prospective Studies; Pulmonary function tests; Quality of life; Research; Respiratory Disease; Respiratory Signs and Symptoms; Risk; Role; Salinas Valley; Schools; Site; Societies; Spirometry; Structure of mucous membrane of nose; Study of Latinos; Sulfur; Symptoms; Testing; Tissues; Visit; Work; agricultural community; agricultural pesticide; air monitoring; airway inflammation; base; cohort; cost; design; early life exposure; emerging adult; epigenetic marker; farm worker; health assessment; methylome; mortality; nasal swab; novel; pesticide exposure; pollutant; potential biomarker; pregnant; prenatal; prospective; pulmonary function; remote sensing; respiratory health; response; urban area; young adult

Abstract In the U.S., there are currently 22.7 million people living with asthma with a large cost to society estimated at $89 billion. Environmental exposures have been identified as playing a role in asthma etiology and lung function growth and the relationship with air pollution exposure is well established in more urban areas. Pesticide exposure has also been related to asthma and decline in lung function in workers. In the Center for the Health Assessment of Mothers And Children Of Salinas (CHAMACOS) Study, a longitudinal study of Latino farmworker families in Salinas California, we observed that early life exposure to several pesticides, as measured by biomarkers or residential proximity to agricultural use, were associated with childhood asthma and poorer lung function at age 7. It is unknown if these relationships persist into adulthood. Few studies have examined the impact of exposure to mixtures of pollutants such as particulate matter and pesticides. Methylation of DNA from nasal cells has been related to asthma and airway inflammation and there is evidence of differential methylation with exposure to pollutants, suggesting a possible link between environmental exposures and respiratory health. The long-term goal of our research is to identify modifiable factors related to respiratory health in a birth cohort that has reached young adulthood. We will leverage the unique CHAMACOS prospective birth cohort study to address these questions. Participants are currently 21 years of age and 500 participants still live near the Salinas Valley, and 250 completed lung function testing at 7 years of age. Our objectives in this proposal are to determine whether early life exposure to pesticides continue to impact their respiratory health in adulthood, identify the relative importance of pesticide and air pollution exposures, periods of susceptibility (prenatal, early life and childhood/adolescence), factors that modify these relationships and potential mechanisms involving the methylation of nasal cells. We hypothesize that higher exposure to pesticides and air pollutants in early life will result in poorer respiratory health and that DNA methylation will be a biomarker of these relationships. We will conduct spirometry testing at 22y and estimate pesticide exposure using California’s unique Pesticide Use Report data for the prenatal, early life (0-3y), childhood/adolescence (4-20y) and recent (previous year) periods. We will estimate exposure to particulate matter air pollution by combining remote sensing and air monitoring data. We will measure methylation in DNA collected from nasal swabs. We will assess whether associations observed in the CHAMACOS cohort between pesticide exposure and respiratory health at 7y persist into early adulthood and determine associations of exposure to a mixture of pesticides and particulate matter with respiratory symptoms, asthma, allergy, and lung function. We will characterize associations of DNA methylation with environmental exposures and respiratory health. In this study, we expect to identify the most important exposures and periods of exposure related to adverse respiratory health. Our findings will help inform future policies related to pesticide use and air quality designed to protect respiratory health.

抽象的 在美国，目前有 2270 万人患有哮喘，估计给社会造成巨大损失 890亿美元。环境暴露已被确定在哮喘病因学和肺部疾病中发挥着重要作用。 在更多城市地区，功能增长以及与空气污染暴露的关系已得到充分证实。农药 接触该物质还与工人的哮喘和肺功能下降有关。在健康中心 萨利纳斯母亲和儿童评估 (CHAMACOS) 研究，一项针对拉丁裔农场工人的纵向研究 在加利福尼亚州萨利纳斯的家庭中，我们观察到，生命早期接触过几种农药，通过测量 生物标志物或居住地靠近农业用途，与儿童哮喘和肺功能较差有关 7岁时就开始发挥功能。目前尚不清楚这些关系是否会持续到成年。很少有研究考察过 接触颗粒物和农药等污染物混合物的影响。 DNA 甲基化 鼻细胞与哮喘和气道炎症有关，并且有证据表明存在差异甲基化 与接触污染物有关，表明环境暴露与呼吸系统健康之间可能存在联系。 我们研究的长期目标是确定与出生时呼吸健康相关的可改变因素 已达到青年期的队列。我们将利用独特的 CHAMACOS 前瞻性出生队列 研究解决这些问题。参与者目前年龄为 21 岁，500 名参与者仍居住在附近 萨利纳斯山谷，250 名 7 岁时完成了肺功能测试。我们在此提案中的目标是 确定生命早期接触农药是否会继续影响成年后的呼吸系统健康， 确定农药和空气污染暴露的相对重要性、易感期（产前、早期 生活和童年/青春期），改变这些关系的因素和涉及的潜在机制 鼻细胞甲基化。我们假设，在生命早期接触更多的农药和空气污染物会导致 导致呼吸系统健康状况恶化，DNA 甲基化将成为这些关系的生物标志物。我们将 在 22 岁时进行肺活量测定测试，并使用加州独特的农药使用来估计农药暴露量 报告产前、生命早期（0-3 岁）、儿童/青春期（4-20 岁）和最近（前一年）时期的数据。 我们将结合遥感和空气监测来估算颗粒物空气污染暴露程度 数据。我们将测量从鼻拭子中收集的 DNA 的甲基化。我们将评估协会是否 在 CHAMACOS 队列中观察到 7 岁时农药接触与呼吸系统健康之间的关系持续到早期 成年期并确定接触农药和颗粒物混合物与 呼吸道症状、哮喘、过敏和肺功能。我们将描述 DNA 甲基化关联的特征 与环境暴露和呼吸系统健康有关。在这项研究中，我们希望确定最重要的 与呼吸道健康不良相关的暴露和暴露时间。我们的发现将有助于为未来提供信息 旨在保护呼吸道健康的与农药使用和空气质量相关的政策。