Prenatal and lifetime exposure to pesticides and particulate matter and respiratory health in young adults from the CHAMACOS birth

CHAMACOS 出生后年轻人的产前和终生接触农药和颗粒物以及呼吸系统健康

• 批准号: 10367205
• 负责人: Robert Gunier
• 金额: $ 58.71万
• 依托单位: UNIVERSITY OF CALIFORNIA BERKELEY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-02-10 至 2026-11-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10367205
• 关键词: 21 year old; 7 year old; Absenteeism; Address; Adolescence; Adult; Age; Age-Years; Agriculture; Air; Air Pollutants; Air Pollution; Airway Disease; Asthma; Biological; Biological Markers; Birth; California; Cells; Child; Childhood; Childhood Asthma; Cohort Studies; Complex; Cross-Sectional Studies; DNA; DNA Methylation; Data; Data Reporting; Disease; Environment; Environmental Exposure; Epigenetic Process; Epithelial Cells; Ethylenes; Etiology; Exposure to; Family; Future; Genes; Goals; Grant; Growth; Hypersensitivity; Individual; Industrial fungicide; Inflammation; Joints; Life; Link; Longitudinal Studies; Measures; Methylation; Mexican Americans; Morbidity - disease rate; Mothers; Nasal Epithelium; Nose; Occupational; Occupational Exposure; Organophosphates; Outcome; Participant; Particulate Matter; Pathway interactions; Persons; Pesticides; Play; Policies; Predisposition; Pregnancy; Prospective Studies; Pulmonary function tests; Quality of life; Research; Respiratory Disease; Respiratory Signs and Symptoms; Risk; Role; Salinas Valley; Schools; Site; Societies; Spirometry; Structure of mucous membrane of nose; Study of Latinos; Sulfur; Symptoms; Testing; Tissues; Visit; Work; agricultural community; agricultural pesticide; air monitoring; airway inflammation; base; cohort; cost; design; early life exposure; emerging adult; epigenetic marker; farm worker; health assessment; methylome; mortality; nasal swab; novel; pesticide exposure; pollutant; potential biomarker; pregnant; prenatal; prospective; pulmonary function; remote sensing; respiratory health; response; urban area; young adult

Abstract In the U.S., there are currently 22.7 million people living with asthma with a large cost to society estimated at $89 billion. Environmental exposures have been identified as playing a role in asthma etiology and lung function growth and the relationship with air pollution exposure is well established in more urban areas. Pesticide exposure has also been related to asthma and decline in lung function in workers. In the Center for the Health Assessment of Mothers And Children Of Salinas (CHAMACOS) Study, a longitudinal study of Latino farmworker families in Salinas California, we observed that early life exposure to several pesticides, as measured by biomarkers or residential proximity to agricultural use, were associated with childhood asthma and poorer lung function at age 7. It is unknown if these relationships persist into adulthood. Few studies have examined the impact of exposure to mixtures of pollutants such as particulate matter and pesticides. Methylation of DNA from nasal cells has been related to asthma and airway inflammation and there is evidence of differential methylation with exposure to pollutants, suggesting a possible link between environmental exposures and respiratory health. The long-term goal of our research is to identify modifiable factors related to respiratory health in a birth cohort that has reached young adulthood. We will leverage the unique CHAMACOS prospective birth cohort study to address these questions. Participants are currently 21 years of age and 500 participants still live near the Salinas Valley, and 250 completed lung function testing at 7 years of age. Our objectives in this proposal are to determine whether early life exposure to pesticides continue to impact their respiratory health in adulthood, identify the relative importance of pesticide and air pollution exposures, periods of susceptibility (prenatal, early life and childhood/adolescence), factors that modify these relationships and potential mechanisms involving the methylation of nasal cells. We hypothesize that higher exposure to pesticides and air pollutants in early life will result in poorer respiratory health and that DNA methylation will be a biomarker of these relationships. We will conduct spirometry testing at 22y and estimate pesticide exposure using California’s unique Pesticide Use Report data for the prenatal, early life (0-3y), childhood/adolescence (4-20y) and recent (previous year) periods. We will estimate exposure to particulate matter air pollution by combining remote sensing and air monitoring data. We will measure methylation in DNA collected from nasal swabs. We will assess whether associations observed in the CHAMACOS cohort between pesticide exposure and respiratory health at 7y persist into early adulthood and determine associations of exposure to a mixture of pesticides and particulate matter with respiratory symptoms, asthma, allergy, and lung function. We will characterize associations of DNA methylation with environmental exposures and respiratory health. In this study, we expect to identify the most important exposures and periods of exposure related to adverse respiratory health. Our findings will help inform future policies related to pesticide use and air quality designed to protect respiratory health.

摘要 在美国，据估计，目前有2270万人患有哮喘， 890亿美元。环境暴露已被确定为在哮喘病因和肺损伤中发挥作用。 在更多的城市地区，功能增长和与空气污染暴露的关系得到了很好的确立。农药 接触也与工人的哮喘和肺功能下降有关。在健康中心 萨利纳斯母亲和儿童评估（CHAMACOS）研究，拉丁美洲农场工人的纵向研究 在加州萨利纳斯的家庭中，我们观察到，早期生活中暴露于几种农药， 生物标志物或住宅接近农业使用，与儿童哮喘和较差的肺 在7岁时就开始工作了。目前还不清楚这些关系是否会持续到成年。很少有研究检查 暴露于污染物混合物（如颗粒物和农药）的影响。DNA的甲基化 鼻细胞与哮喘和气道炎症有关，有证据表明存在差异甲基化 这表明环境暴露与呼吸系统健康之间可能存在联系。 我们研究的长期目标是确定与出生时呼吸健康相关的可改变因素 已进入青年期的群体。我们将利用独特的CHAMACOS前瞻性出生队列 研究解决这些问题。参与者目前年龄为21岁，500名参与者仍居住在 Salinas Valley，250名儿童在7岁时完成了肺功能测试。我们在这项建议中的目标是 为了确定生命早期接触农药是否会继续影响他们成年后的呼吸系统健康， 确定农药和空气污染暴露的相对重要性，易感时期（产前，早期 生活和童年/青春期），改变这些关系的因素和涉及这些关系的潜在机制。 鼻细胞的甲基化。我们假设，在生命早期接触杀虫剂和空气污染物的程度较高， 导致更差的呼吸系统健康，DNA甲基化将是这些关系的生物标志物。我们将 在22岁时进行肺量计测试，并使用加州独特的农药使用评估农药暴露 报告产前、生命早期（0- 3岁）、儿童/青春期（4- 20岁）和最近（前一年）的数据。 我们将结合遥感和空气监测来估计暴露于颗粒物空气污染 数据我们将测量从鼻拭子收集的DNA中的甲基化。我们将评估协会是否 在CHAMACOS队列中观察到的农药暴露与7年呼吸系统健康之间的关系持续到早期， 并确定暴露于农药和颗粒物的混合物与 呼吸道症状哮喘过敏和肺功能我们将描述DNA甲基化 环境暴露和呼吸系统健康。在这项研究中，我们希望找出最重要的 与有害呼吸系统健康有关的接触和接触时间。我们的研究结果将有助于未来 与农药使用和空气质量有关的政策，旨在保护呼吸系统健康。