Effects of exposure to maternal psychosocial stress and stress hormones during peregnancy on endocrine, cardiovascular, metabolic and immune parameters in 6-7 year old children: a prospective cohort study

孕期母亲心理社会压力和应激激素暴露对6-7岁儿童内分泌、心血管、代谢和免疫参数的影响：一项前瞻性队列研究

• 批准号: 45584454
• 负责人: Professorin Dr. Sonja Entringer
• 金额: --
• 依托单位: Behavioral Perinatology Research Program (aufgelöst)
• 依托单位国家: 德国
• 项目类别: Research Fellowships
• 财政年份: 2007
• 资助国家: 德国
• 起止时间: 2006-12-31 至 2010-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/45584454?language=en
• 关键词: Effects; exposure; maternal; psychosocial; stress

Empirical studies support a significant role for prenatal stress exposure as an independent risk factor for a host of adverse infant and adult health outcomes. In humans, the major limitations in this field are that an overwhelming majority of these studies have (a) employed a retrospective design, and (b) used indirect markers of adverse prenatal conditions such as reduced birth weight/size and length of gestation as predictors of subsequent health outcomes. To address the above limitations, the goal of the present study proposal is to prospectively assess the effects of prenatal stress exposure (psychosocial stress of the mother during pregnancy and maternal-placental stress hormone levels during pregnancy) on endocrine, cardiovascular, metabolic and immune parameters in 6-7 year old children whose mothers’ pregnancies were followed with multiple serial measures. Moreover, instead of relying exclusively on self-report measures of maternal psychosocial stress collected during pregnancy, measures of maternal-placental stress hormones (levels of cortisol and corticotropin releasing hormone, CRH) that also were collected at multiple time points over the course of the index pregnancy will be used as biological markers of fetal exposure to a prenatal stress. Results of the proposed study will contribute to further understand whether conditions during fetal development account for variation in the function of important biological systems that underlie subsequent health and disease risk.

实证研究支持产前压力暴露作为一个独立的危险因素，对一系列不利的婴儿和成人的健康结果的重要作用。在人类中，这一领域的主要局限性是绝大多数研究（a）采用了回顾性设计，（B）使用了不良产前状况的间接标志物，如出生体重/体型减少和妊娠期长短作为随后健康结局的预测因子。为了解决上述局限性，本研究的目的是前瞻性地评估产前压力暴露（母亲在怀孕期间的心理社会压力和母亲在怀孕期间的胎盘应激激素水平）对6-7岁儿童的内分泌，心血管，代谢和免疫参数的影响，这些儿童的母亲怀孕后进行了多次连续测量。此外，而不是完全依赖于在怀孕期间收集的母亲心理社会压力的自我报告措施，母亲-胎盘应激激素（皮质醇和促肾上腺皮质激素释放激素，CRH的水平），也收集了在多个时间点的过程中的索引怀孕将被用作胎儿暴露于产前压力的生物标志物。拟议研究的结果将有助于进一步了解胎儿发育期间的条件是否会导致重要生物系统功能的变化，这些变化是随后健康和疾病风险的基础。