Colorectal tumorigenesis on a cricket powder-based diet versus diets based on more typical protein sources

基于蟋蟀粉的饮食与基于更典型蛋白质来源的饮食的结直肠肿瘤发生

基本信息

  • 批准号:
    10368084
  • 负责人:
  • 金额:
    $ 7.55万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2021
  • 资助国家:
    美国
  • 起止时间:
    2021-03-08 至 2023-08-31
  • 项目状态:
    已结题

项目摘要

Although some debate continues over the precise strength of the scientific evidence, there remains a strong consensus that habitual consumption of processed meat is a prominent causal risk factor for colorectal cancer (CRC). Two recent systematic reviews have concluded that each additional 50 gram serving/day of processed meat conveys an 18-23% increased risk, a figure highly relevant to U.S. adults whose mean daily consumption of processed meat is 50-60 grams. Substituting a modest proportion of that meat with an alternative protein source with lesser risk could therefore have a major impact on reducing the societal burden of CRC. Although an important protein source in many cultures for centuries, only recently have select insect species begun to gain traction as an acceptable protein source in North America. Cricket powder, comprised of ground, whole roasted crickets, can be incorporated into many foodstuffs with little or no discernible change in taste, making it an excellent candidate for acceptance in a culture naïve to entomophagy. Moreover, not only is its protein content very high, but qualitatively it is a complete protein. Further, cricket powder’s unique array of physiochemical features indicate it may possess cancer-preventive properties. Nevertheless an examination of insect-based foodstuffs for the purpose of cancer prevention has never before been explored, so the scope of this exploratory proposal is highly consistent with the spirit of the R03 mechanism. Achieving protein requirements through entomophagy has the further advantage of promoting sustainable agriculture, a longstanding goal of the U.S. Department of Agriculture. We hypothesize that in a well-accepted animal model of CRC, tumorigenesis will be diminished by a diet whose protein is largely derived from cricket powder compared to one whose protein is derived from processed meat, and will be non-inferior to the tumorigenesis observed with diets whose protein is derived from the conventional non-meat sources, dairy and soy. Our long-term goal is to identify a novel approach to CRC prevention that is effective, non-invasive, well- tolerated, and low cost, and thus will have wide application both domestically and globally. A secondary long- term goal is to promote sustainable food systems. We propose to conduct a study in a murine model of obesity- promoted colorectal carcinogenesis to: 1) determine whether substitution with cricket powder attenuates the enhanced risk of colorectal neoplasia that accompanies the habitual consumption of processed meat, 2) examine whether tumorigenesis generated by a cricket powder-based diet is non-inferior to diets whose protein is derived from soy flour or whole milk solids, and 3) begin to delineate the biochemical, molecular, and cytokinetic pathways by which a cricket-powder based diet generates less tumorigenesis than a processed meat one. My laboratory has successfully pursued a wide array of research topics in the nutritional chemoprevention of colorectal carcinogenesis in various animal models for over 25 years, providing us with all the necessary expertise to conduct the proposed study expeditiously and with scientific rigor.
尽管对科学证据的确切强度仍有一些争论,但仍然有一个强有力的

项目成果

期刊论文数量(1)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Protein binding assays for an accurate differentiation of vitamin B12 from its inactive analogue. A study on edible cricket powder.
蛋白质结合测定法,以准确分化维生素B12与其无活性类似物的分化。一项关于食用板球粉的研究。
  • DOI:
    10.1016/j.fochx.2023.100824
  • 发表时间:
    2023-10-30
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Fedosov SN;Nexo E;Heegaard CW;Goldin J;Mason JB
  • 通讯作者:
    Mason JB
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JOEL B MASON其他文献

JOEL B MASON的其他文献

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{{ truncateString('JOEL B MASON', 18)}}的其他基金

FASEB SRC: The Folate, Vitamin B12, and One-Carbon Metabolism Conference
FASEB SRC:叶酸、维生素 B12 和一碳代谢会议
  • 批准号:
    10539408
  • 财政年份:
    2022
  • 资助金额:
    $ 7.55万
  • 项目类别:
Colorectal tumorigenesis on a cricket powder-based diet versus diets based on more typical protein sources
基于蟋蟀粉的饮食与基于更典型蛋白质来源的饮食的结直肠肿瘤发生
  • 批准号:
    10198460
  • 财政年份:
    2021
  • 资助金额:
    $ 7.55万
  • 项目类别:
Defining the promoting effect of folate on colorectal cancer in a novel animal mo
在新型动物模型中确定叶酸对结直肠癌的促进作用
  • 批准号:
    8213454
  • 财政年份:
    2011
  • 资助金额:
    $ 7.55万
  • 项目类别:
Defining the promoting effect of folate on colorectal cancer in a novel animal mo
在新型动物模型中确定叶酸对结直肠癌的促进作用
  • 批准号:
    8049302
  • 财政年份:
    2011
  • 资助金额:
    $ 7.55万
  • 项目类别:
The MTHFR C677T SNP exerts bipolar effects on colorectal cancer risk through the
MTHFR C677T SNP 通过以下方式对结直肠癌风险产生双极效应:
  • 批准号:
    7713460
  • 财政年份:
    2009
  • 资助金额:
    $ 7.55万
  • 项目类别:
The MTHFR C677T SNP exerts bipolar effects on colorectal cancer risk through the
MTHFR C677T SNP 通过以下方式对结直肠癌风险产生双极效应:
  • 批准号:
    7944033
  • 财政年份:
    2009
  • 资助金额:
    $ 7.55万
  • 项目类别:
The role of the extracellular calcium-sensing receptor in dietary Ca2+ chemopreve
细胞外钙敏感受体在膳食 Ca2 化学预防中的作用
  • 批准号:
    7270119
  • 财政年份:
    2006
  • 资助金额:
    $ 7.55万
  • 项目类别:
One-carbon nutrients in cancer prevention
一碳营养素预防癌症
  • 批准号:
    6598043
  • 财政年份:
    2003
  • 资助金额:
    $ 7.55万
  • 项目类别:
One-carbon nutrients in cancer prevention
一碳营养素预防癌症
  • 批准号:
    7114292
  • 财政年份:
    2003
  • 资助金额:
    $ 7.55万
  • 项目类别:
One-carbon nutrients in cancer prevention
一碳营养素预防癌症
  • 批准号:
    7284838
  • 财政年份:
    2003
  • 资助金额:
    $ 7.55万
  • 项目类别:

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