FASEB SRC: The Folate, Vitamin B12, and One-Carbon Metabolism Conference

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The biennial conference entitled “Folate, Vitamin B12 and One-Carbon Metabolism” will be held at the Renaissance Hotel in Asheville, NC, August 14-19, 2022. This conference, which is part of the Federation of American Societies for Experimental Biology (FASEB) Summer Research Conference (SRC) series has been convened every two years since its inception in 1986. The philosophy of the conference is to bring together basic researchers, clinicians, and public health experts to present and discuss the latest developments related to B vitamins and one-carbon metabolism. The conference is typically attended by the most prominent experts in the field from around the world, as well as young investigators completing their doctoral and postdoctoral studies. The Specific Aims of the conference are to: 1) convene world experts and trainees in the area of B vitamins and one-carbon metabolism to present and discuss the latest, cutting edge research, emphasizing unpublished data; 2) provide opportunities for trainees and investigators new to this meeting to present their work, receive feedback from established investigators in the field, and develop collaborations and professional connections; and 3) promote attendance at the conference by providing travel funding for invited speakers and awarding travel prizes to graduate and postdoctoral trainees for outstanding oral and poster presentations. Funds are allocated to enhance attendance by under-represented minorities and to enhance their active participation. Scientific highlights of the 2022 meeting include sessions on: 1) 1-carbon nutrients, their metabolism, and cancer, 2) the roles of the microbiome in 1-carbon metabolism, 3) basic aspects of one-carbon metabolism and their clinical implications, 4) the role of 1-carbon nutrients and their metabolism in chronic disease, 5) hereditary disorders of 1-carbon metabolism, 6) the updates required for the Dietary Recommended Intakes (DRIs) of 1-carbon nutrients (a workshop format), 7) potential adverse effects of excess intake of folic acid: an ongoing controversy, 8) the relationship between 1-carbon metabolism and maternal and offspring health, and 9) the idiosyncratic dependence of methionine by cancer cells. The specific aims will be achieved through 10 sessions consisting of oral presentations from invited speakers (30 minute talks) and from selected abstracts submitted to the conference (15 minute talks; expanding opportunities for trainees to give oral presentations), two poster sessions (2 hours each), and two ‘meet-the- expert/career development’ sessions in which trainees and young investigators will meet with senior investigators to discuss research and professional development. There also will be ample opportunities for informal interactions among the participants during meals, breaks, poster sessions, and outdoor recreational activities. These interactions will catalyze new research directions and collaborations, promote the professional development of young investigators, and invigorate the future of the field.