Cardiopulmonary effects induced by electronic-cigarette and JUUL aerosols in both in vivo and in vitro models.

电子烟和 JUUL 气雾剂在体内和体外模型中诱导的心肺效应。

基本信息

项目摘要

PROJECT SUMMARY/ABSTRACT Candidate background: I received my PhD from the University of Montreal (Canada) with a dissertation on pulmonary responses induced by inhaled TiO2 nanoparticles. This research provided me with a solid expertise in lung biology and inhalation toxicology. During my post-doctorate at Louisiana State University (LSU) under the supervision of Dr. Arthur Penn, I received high quality training in tobacco science, including on second-hand smoke and electronic-cigarettes (e-cigs). I am currently an Assistant Professor at LSU, with a research program that focuses on electronic nicotine delivery systems (ENDS) and their pulmonary health effects. Career goals and objectives: My long-term career goals are to become a well-funded independent scientist in the fields of tobacco regulatory science, as well as to attain a tenured Professorship in a research-intensive academic institution. My research goals are to enhance our understanding of the impact of e-cig and JUUL aerosol exposures on lung development and on cardiopulmonary responses. This mentored award will support my career goals by providing protected time to learn new techniques and expertise from my mentoring team. Career development and training activities: I plan to use this mentored award to gain expertise in lung immunology and cardiovascular effects caused by exposures to tobacco-related products to complement my expertise in tobacco-related pulmonary effects. This will be supported by my mentoring team. Dr. Stephania Cormier will be my primary mentor in flow cytometry and lung immunity. Dr. Kent Pinkerton’s mentoring will allow me to expand from solely pulmonary assessment to cardiovascular evaluations of effects induced by ENDS. Dr. Tammy Dugas will be my primary mentor in assessing vascular function in mouse models following exposures to ENDS aerosols. I will also complete a bioinformatics course, attend seminars and present at conferences. Research strategy – Summary: The prevalence of ENDS use in the US is 8 million adults, of whom 70% are dual-users of classic cigarettes and e-cigs. Little is known regarding the cardiopulmonary effects due to chronic inhalation of ENDS aerosols. Clinical evidence demonstrates declines in lung function and increases in risks of myocardial infarction in healthy dual-users. Since biomarkers of harm with predictive value for cardiopulmonary diseases in dual-users exist, we hypothesize that these biomarkers can serve as a basis for the evaluation of cardiopulmonary toxicity related to long-term inhalation exposures to e-cig or JUUL in single-users. We will study how two ENDS products of different design -- 1) open system e-cig devices, and 2) closed system JUUL devices -- impact individual or combinations of the constituents found in these aerosols, and their toxicity. Our goals are A) to examine the roles that e-liquid constituents play in the chemical profile and in vitro toxicity of ENDS aerosols; and B) to define a panel of biomarkers for cardiopulmonary effects following exposures to either dual- use of cigarettes and e-cigs, or sole exposures to e-cig or JUUL aerosols using in vivo models. Thus, this study has a high societal impact since it will help inform the regulatory agencies and the 8 million adults ENDS users.
项目摘要/摘要 候选人背景:我在蒙特利尔大学(加拿大)获得博士学位,博士学位论文是关于 吸入纳米二氧化钛引起的肺部反应。这项研究为我提供了坚实的专业知识 肺部生物学和吸入毒理学。我在路易斯安那州立大学(LSU)攻读博士后期间 在Arthur Penn博士的指导下,我接受了高质量的烟草科学培训,包括二手烟草 吸烟和电子烟(电子烟)。我目前是路易斯安那州立大学的助理教授,有一个研究项目 重点是电子尼古丁递送系统(END)及其对肺部健康的影响。 职业目标和目标:我的长期职业目标是成为一名资金雄厚的独立科学家 烟草监管科学领域,以及在一个研究密集型的终身教授职位 学术机构。我的研究目标是加深我们对电子烟和JUUL的影响的了解 气溶胶暴露对肺发育和心肺反应的影响。这一指导奖将支持 我的职业目标是提供受保护的时间,从我的指导团队那里学习新的技术和专业知识。 职业发展和培训活动:我计划利用这个指导奖来获得肺方面的专业知识 烟草相关产品暴露引起的免疫学和心血管效应 烟草相关肺部影响方面的专业知识。这将得到我的指导团队的支持。斯蒂芬尼娅博士 科米尔将是我在流式细胞术和肺免疫方面的主要导师。肯特·平克顿博士的指导将允许 我将从单纯的肺评估扩展到心血管评估,以评估EDS的影响。Dr。 塔米·杜加斯将是我评估暴露后小鼠模型血管功能的主要导师 结束气雾剂。我还将完成一门生物信息学课程,参加研讨会并出席会议。 研究策略-综述:美国终端使用率为800万成年人,其中70%是 古典香烟和电子烟的双重使用者。慢性阻塞性肺疾病对心肺的影响知之甚少 吸入末端气雾剂。临床证据表明,肺功能下降,风险增加 健康的双重使用者中的心肌梗死。由于生物标志物对心肺功能具有预测价值 疾病的存在,我们假设这些生物标志物可以作为评估的基础 单一使用者与长期吸入e-cig或jul有关的心肺毒性。我们会研究 不同设计的两个终端产品--1)开放系统电子CIG设备,2)封闭系统JUUL设备 -影响在这些气雾剂中发现的单个或组合的成分及其毒性。我们的目标是 A)审查电子液体成分在末端化合物的化学特性和体外毒性中的作用 气雾剂;以及B)定义一组生物标志物,用于在暴露于两种环境中的一种情况下对心肺的影响。 使用香烟和电子烟,或使用活体模型单独暴露于电子烟或Juul气雾剂。因此,这项研究 具有很高的社会影响,因为它将有助于向监管机构和800万成年人最终用户提供信息。

项目成果

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Alexandra Noel其他文献

Alexandra Noel的其他文献

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{{ truncateString('Alexandra Noel', 18)}}的其他基金

Effects of nicotine salt-rich JUUL aerosols on the mouse developing lung
富含尼古丁盐的 JUUL 气雾剂对小鼠肺部发育的影响
  • 批准号:
    10194831
  • 财政年份:
    2020
  • 资助金额:
    $ 16.99万
  • 项目类别:
Cardiopulmonary effects induced by electronic-cigarette and JUUL aerosols in both in vivo and in vitro models.
电子烟和 JUUL 气雾剂在体内和体外模型中诱导的心肺效应。
  • 批准号:
    10563196
  • 财政年份:
    2020
  • 资助金额:
    $ 16.99万
  • 项目类别:
Inhalation Toxicology Core (ITC)
吸入毒理学核心 (ITC)
  • 批准号:
    10576459
  • 财政年份:
    2009
  • 资助金额:
    $ 16.99万
  • 项目类别:
Inhalation Toxicology Core (ITC)
吸入毒理学核心 (ITC)
  • 批准号:
    10116405
  • 财政年份:
    2009
  • 资助金额:
    $ 16.99万
  • 项目类别:
Inhalation Toxicology Core (ITC)
吸入毒理学核心 (ITC)
  • 批准号:
    10341191
  • 财政年份:
    2009
  • 资助金额:
    $ 16.99万
  • 项目类别:

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