Alcohol-related sleep disturbances and circuit dynamics of arousal neuropeptides
酒精相关的睡眠障碍和唤醒神经肽的回路动力学
基本信息
- 批准号:10373277
- 负责人:
- 金额:$ 24.9万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-06-01 至 2024-05-31
- 项目状态:已结题
- 来源:
- 关键词:AffectAlcohol consumptionAlcohol withdrawal syndromeAlcoholismAlcoholsAmygdaloid structureAnatomyAnimal ModelAnimalsAnxietyArousalAutomobile DrivingAxonBehavioralBlood alcohol level measurementBrainCalciumCellsCharacteristicsChronicChronic DiseaseCorticotropin-Releasing HormoneDevelopmentDrug abuseElectroencephalogramElectroencephalographyFiberFluorescenceFunctional Magnetic Resonance ImagingFutureHeavy DrinkingHyperactivityHypothalamic structureIndividualKnowledgeLaboratoriesLateralLifeLinkMeasurementMediatingMetabolicMethodsMonitorMotivationMusNegative ReinforcementsNeurobiologyNeurocognitiveNeuronal PlasticityNeuronsNeuropeptidesOutputPathway interactionsPatternPharmaceutical PreparationsPhotometryPhysiologicalPhysiologyPopulationProcessPublic HealthReceptor SignalingRelapseResearchRestRewardsRodentScientific Advances and AccomplishmentsSeizuresSignal TransductionSleepSleep DeprivationSleep Wake CycleSleep disturbancesSleeplessnessSocietiesStressStructureStructure of terminal stria nuclei of preoptic regionSubgroupSystemTechniquesTestingTimeVentral Tegmental AreaViralWakefulnessWaterWithdrawaladdictionalcohol effectalcohol exposurealcohol monitoringalcohol seeking behavioralcohol use disorderallostasisallostatic loadanxiety-like behaviorbinge drinkingcell typecircadiandesigndrinkingdrug relapsedrug rewarddrug withdrawalemotional behavioremotional stimulusexperimental studyhypocretinimprovedin vivonegative emotional stateneural circuitneuroimagingneurophysiologynew technologynext generationnon rapid eye movementoptogeneticspoor sleepproblem drinkerrelating to nervous systemresponsesleep qualitytool
项目摘要
Project Summary
Alcoholism is a chronic disorder with severe consequences to physiology of affected individuals, and far-
reaching effects on society in general. In particular, further research is required to advance scientific
knowledge of the intricate neurobiology underlying the relationship between excessive alcohol drinking and
deficits in sleep, a fundamental component of life. This proposal will integrate in vivo measurements of neural
calcium activity with electroencephalogram sleep recordings in animal models of long-term, free-choice
intermittent heavy alcohol exposure, in order to establish (or refute) causal relationships between the
hypothalamic hypocretin system, extended amygdala corticotropin-releasing factor system, and stress-like
states of hyperarousal (disrupted sleep) during alcohol withdrawal. Knowledge gained from the proposed
experiments will inform future strategies for mitigation of drug abuse and relapse.
项目摘要
酒精中毒是一种慢性疾病,对受影响的个人的生理造成严重后果,
对整个社会产生影响。特别是,需要进一步研究,
关于过量饮酒与神经系统疾病之间关系的复杂神经生物学知识,
睡眠不足是生命的基本组成部分这项建议将整合在体内测量的神经
在长期自由选择的动物模型中,
间歇性重度酒精暴露,以建立(或反驳)
下丘脑下丘脑分泌素系统、杏仁核促肾上腺皮质激素释放因子系统和应激样
酒精戒断期间的过度觉醒状态(睡眠中断)。从拟议方案中获得的知识
实验将为今后减少药物滥用和复吸的战略提供信息。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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William J Giardino其他文献
William J Giardino的其他文献
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{{ truncateString('William J Giardino', 18)}}的其他基金
Alcohol-related sleep disturbances and circuit dynamics of arousal neuropeptides
酒精相关的睡眠障碍和唤醒神经肽的回路动力学
- 批准号:
10405071 - 财政年份:2021
- 资助金额:
$ 24.9万 - 项目类别:
Alcohol-related sleep disturbances and circuit dynamics of arousal neuropeptides
酒精相关的睡眠障碍和唤醒神经肽的回路动力学
- 批准号:
10630278 - 财政年份:2021
- 资助金额:
$ 24.9万 - 项目类别:
Alcohol-related sleep disturbances and circuit dynamics of arousal neuropeptides
酒精相关的睡眠障碍和唤醒神经肽的回路动力学
- 批准号:
10617073 - 财政年份:2021
- 资助金额:
$ 24.9万 - 项目类别:
Alcohol-related sleep disturbances and circuit dynamics of arousal neuropeptides
酒精相关的睡眠障碍和唤醒神经肽的回路动力学
- 批准号:
10846888 - 财政年份:2021
- 资助金额:
$ 24.9万 - 项目类别:
Optogenetic studies of hypocretin in binge drinking and negative hedonic valence
酗酒和负享乐价中下丘脑分泌素的光遗传学研究
- 批准号:
8648432 - 财政年份:2013
- 资助金额:
$ 24.9万 - 项目类别:
Optogenetic studies of hypocretin in binge drinking and negative hedonic valence
酗酒和负享乐价中下丘脑分泌素的光遗传学研究
- 批准号:
8974206 - 财政年份:2013
- 资助金额:
$ 24.9万 - 项目类别:
Edinger-Westphal Urocortin-1 Involvement in Binge Ethanol Intake and Reward
Edinger-Westphal Urocortin-1 参与暴饮暴食乙醇摄入和奖励
- 批准号:
8356258 - 财政年份:2011
- 资助金额:
$ 24.9万 - 项目类别:
Edinger-Westphal Urocortin-1 Involvement in Binge Ethanol Intake and Reward
Edinger-Westphal Urocortin-1 参与暴饮暴食乙醇摄入和奖励
- 批准号:
8251695 - 财政年份:2011
- 资助金额:
$ 24.9万 - 项目类别:
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