Alcohol-related sleep disturbances and circuit dynamics of arousal neuropeptides

酒精相关的睡眠障碍和唤醒神经肽的回路动力学

• 批准号: 10373277
• 负责人: William J Giardino
• 金额: $ 24.9万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-06-01 至 2024-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10373277
• 关键词: Affect; Alcohol consumption; Alcohol withdrawal syndrome; Alcoholism; Alcohols; Amygdaloid structure; Anatomy; Animal Model; Animals; Anxiety; Arousal; Automobile Driving; Axon; Behavioral; Blood alcohol level measurement; Brain; Calcium; Cells; Characteristics; Chronic; Chronic Disease; Corticotropin-Releasing Hormone; Development; Drug abuse; Electroencephalogram; Electroencephalography; Fiber; Fluorescence; Functional Magnetic Resonance Imaging; Future; Heavy Drinking; Hyperactivity; Hypothalamic structure; Individual; Knowledge; Laboratories; Lateral; Life; Link; Measurement; Mediating; Metabolic; Methods; Monitor; Motivation; Mus; Negative Reinforcements; Neurobiology; Neurocognitive; Neuronal Plasticity; Neurons; Neuropeptides; Output; Pathway interactions; Pattern; Pharmaceutical Preparations; Photometry; Physiological; Physiology; Population; Process; Public Health; Receptor Signaling; Relapse; Research; Rest; Rewards; Rodent; Scientific Advances and Accomplishments; Seizures; Signal Transduction; Sleep; Sleep Deprivation; Sleep Wake Cycle; Sleep disturbances; Sleeplessness; Societies; Stress; Structure; Structure of terminal stria nuclei of preoptic region; Subgroup; System; Techniques; Testing; Time; Ventral Tegmental Area; Viral; Wakefulness; Water; Withdrawal; addiction; alcohol effect; alcohol exposure; alcohol monitoring; alcohol seeking behavior; alcohol use disorder; allostasis; allostatic load; anxiety-like behavior; binge drinking; cell type; circadian; design; drinking; drug relapse; drug reward; drug withdrawal; emotional behavior; emotional stimulus; experimental study; hypocretin; improved; in vivo; negative emotional state; neural circuit; neuroimaging; neurophysiology; new technology; next generation; non rapid eye movement; optogenetics; poor sleep; problem drinker; relating to nervous system; response; sleep quality; tool

Project Summary Alcoholism is a chronic disorder with severe consequences to physiology of affected individuals, and far- reaching effects on society in general. In particular, further research is required to advance scientific knowledge of the intricate neurobiology underlying the relationship between excessive alcohol drinking and deficits in sleep, a fundamental component of life. This proposal will integrate in vivo measurements of neural calcium activity with electroencephalogram sleep recordings in animal models of long-term, free-choice intermittent heavy alcohol exposure, in order to establish (or refute) causal relationships between the hypothalamic hypocretin system, extended amygdala corticotropin-releasing factor system, and stress-like states of hyperarousal (disrupted sleep) during alcohol withdrawal. Knowledge gained from the proposed experiments will inform future strategies for mitigation of drug abuse and relapse.

项目摘要 酒精中毒是一种慢性疾病，对受影响的个人的生理造成严重后果， 对整个社会产生影响。特别是，需要进一步研究， 关于过量饮酒与神经系统疾病之间关系的复杂神经生物学知识， 睡眠不足是生命的基本组成部分这项建议将整合在体内测量的神经 在长期自由选择的动物模型中， 间歇性重度酒精暴露，以建立（或反驳） 下丘脑下丘脑分泌素系统、杏仁核促肾上腺皮质激素释放因子系统和应激样 酒精戒断期间的过度觉醒状态（睡眠中断）。从拟议方案中获得的知识 实验将为今后减少药物滥用和复吸的战略提供信息。