Cannabis' Impact on Alcohol Consumption: Integrating Laboratory and Ecological Momentary Assessment Methods

大麻对酒精消费的影响：整合实验室和生态瞬时评估方法

• 批准号: 10339931
• 负责人: JANE METRIK
• 金额: $ 69.19万
• 依托单位: BROWN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-04-01 至 2027-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10339931
• 关键词: Acute; Address; Alcohol consumption; Alcohol dependence; Alcohols; Animal Model; Area; Cannabidiol; Cannabinoids; Cannabis; Cellular Phone; Clinical Data; Clinical Research; Consumption; Cues; DSM-V; Data; Devices; Dose; Ecological momentary assessment; Environment; Event; Heavy Drinking; Human; Individual; Laboratories; Laboratory Study; Life; Link; Location; Marijuana; Measures; Medical; Methods; Motivation; Near-Infrared Spectroscopy; Outcome; Participant; Pattern; Persons; Pharmacodynamics; Phase; Placebos; Prevention; Psychological reinforcement; Psychotropic Drugs; Public Health; Publishing; Randomized; Reporting; Research; Risk; Role; Science; Self Administration; Severities; Smoke; Testing; Tetrahydrocannabinol; Treatment outcome; United States National Institutes of Health; Work; addiction; alcohol abuse therapy; alcohol behavior; alcohol consequences; alcohol craving; alcohol demand; alcohol effect; alcohol measurement; alcohol response; alcohol risk; alcohol use disorder; base; contextual factors; craving; design; development policy; drinking; economic impact; health economics; incentive salience; indexing; marijuana use; mobile computing; prospective; social

PROJECT SUMMARY/ABSTRACT Cannabis is the most common psychoactive drug co-used with alcohol among individuals with alcohol use disorder (AUD). The current proposal advances our team’s research on the impact of cannabis use (CU) and cannabis-alcohol co-use on alcohol-related outcomes. Findings from clinical studies indicate that CU is strongly linked with alcohol use, although evidence regarding whether cannabis reduces or increases drinking is mixed. Our research has demonstrated that Δ-9-tetrahydrocannabinol (THC) acutely reduces relative alcohol value and consumption in heavy cannabis and alcohol co-users under controlled laboratory conditions. Evidence from animal models on cannabidiol (CBD) suggests CBD may also reduce alcohol craving and consumption. An important gap in current clinical research is lack of human laboratory studies that examine alcohol consumption in relation to cannabis varying in cannabinoid composition (THC and CBD). Moreover, aside from data on pharmacodynamic interactions between cannabis and alcohol, no human laboratory studies have examined the combined effects of alcohol and cannabis (i.e., marijuana; simultaneous use-SAM) on alcohol consumption. Finally, no previous study has evaluated the impact of cannabis on alcohol use within the same individual under both controlled laboratory conditions and in the natural environment. This project will provide the most comprehensive tests of the impact of cannabis on alcohol outcomes using a multi-method design: (1) controlled laboratory administration of THC versus CBD smoked alone versus simultaneously with alcohol and (2) ecological momentary assessment (EMA) of event-level contextual factors that can help elucidate the associations between CU and alcohol-related outcomes in daily life contexts. The laboratory phase will employ a 3 (within-subjects cannabinoid dose: 12% THC/<1% CBD, 12% CBD/<1%THC, placebo) X 2 (between-subjects: cannabis + an alcohol-priming dose versus cannabis + alcohol placebo) mixed factorial design to examine these effects on subsequent drinking in 200 nontreatment-seeking heavy episodic alcohol drinkers who use cannabis weekly (Aim 1). Data from this laboratory phase will be integrated with smartphone- based data on CU patterns (amount, THC/CBD ratio, potency, mode), context (location, social), alcohol craving, consumption, and consequences collected from the same individuals over a 4-week EMA period. Integration of laboratory and EMA data enables examining the unique influences of laboratory-based cannabis state-dependent alcohol response variables and field-based CU and contextual factors on alcohol craving, consumption, and consequences (Aim 2). Cannabis (medical and recreational) and SAM motives and AUD severity will be explored as potential moderators of the associations between CU and alcohol behaviors in the natural environment (Aim 3). This research is well-aligned with the objectives of the Collaborative Research on Addiction at NIH and has important implications for cannabis regulatory science and AUD treatment by addressing the relative impact of specific cannabinoids as well as contextual risk in cannabis-alcohol co-use.

项目总结/文摘