Asthma Endotypes: Mechanisms and Consequences for Airway Epithelium and Mucus
哮喘内型:气道上皮和粘液的机制和后果
基本信息
- 批准号:10371127
- 负责人:
- 金额:$ 179.79万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-05-08 至 2023-03-31
- 项目状态:已结题
- 来源:
- 关键词:2019-nCoVAdultAffectAgeAspirate substanceAsthmaBiologicalBiological AssayCOVID-19COVID-19 pandemicCOVID-19 patientCase Fatality RatesChinaChronicClinicalClinical ResearchClinical TrialsCommunitiesCoronavirusDNA Sequencing FacilityDevelopmentDiabetes MellitusDiseaseDisease OutcomeElementsEnrollmentEnvironmental Risk FactorFamilyGeneral HospitalsGeneticGenetic RiskHealthHealthcare SystemsHypertensionImmune System DiseasesImmune responseImmunologicsImmunophenotypingIndividualInstitutionInterventionInvestigationLaboratoriesLung diseasesMedicalMedical centerMetagenomicsMethodsMucous body substanceMyocardial IschemiaNational Institute of Allergy and Infectious DiseaseNatureOnset of illnessOutcomeParticipantPathogenicityPatientsPeripheral Blood Mononuclear CellPersonal SatisfactionPhage DisplayPhage ImmunoPrecipitation SequencingPharmaceutical PreparationsPneumoniaPrognostic MarkerRecurrenceResourcesRisk FactorsSARS-CoV-2 infectionSample SizeSamplingSan FranciscoSerologySerumSeverity of illnessSiteTherapeutic AgentsVariantViral Load resultVirusairway epitheliumbasebiomarker developmentclinical centerclinical riskcohortcomorbiditydesigneffective therapyendotrachealglobal healthhealth care availabilityimprovedinclusion criteriamembermortalityneutralizing antibodyneutralizing vaccinenext generation sequencingnovelnovel therapeuticsnovel viruspandemic diseasepathogenperipheral bloodprospectiverespiratoryresponsesocial structuretherapeutic targettranscriptome sequencingtrauma centerswelfare
项目摘要
PROJECT SUMMARY/ABSTRACT
COVID-19, the pandemic illness caused by the novel virus SARS-CoV-2, is a serious respiratory illness that
has high infectivity and a mortality rate that varies from <1% to up to 20% depending on underlying risk factors.
Indeed, disease severity varies markedly based on recognized clinical risk factors (age and co-morbidities).
The biological underpinnings of this clinical variability are unknown but likely relate to variation in both the virus
and the host response. A detailed understanding of the risk factors for severe disease, including genetic and
environmental factors and the nature of the host immunological response, is essential for the development of
prognostic biomarkers and effective therapies. To meet this urgent need we propose to help develop and to
participate in the IMPACC multi-center longitudinal clinical study of hospitalized patients with COVID-19 and to
immunophenotype participants using shared immunological methods that will be designed an carried out by
core laboratories at UCSF and at other participating institutions. Our specific aims are 1) to develop a
prospective observational convenience cohort of adult subjects hospitalized with known or presumptive
COVID-19, 2) to use this cohort to describe the relationship between specific immunologic assessments and
clinical course of COVID-19 in hospitalized patients, and 3) to implement three core laboratories at UCSF to
support immunophenotyping in this multicenter cohort. These core laboratories will perform bulk RNA
sequencing of blood peripheral blood mononuclear cells (PBMC), bulk metagenomic next-generation
sequencing (mNGS) on endotracheal aspirate samples, and serologic phage display assays (PhIP-Seq).
Successful completion of these aims will yield critical information regarding the relationship between viral load,
host immunological responses, and poor clinical outcomes that are urgently needed for biomarker
development and rational therapeutic targeting. In addition, the cellular samples banked in this study may
directly contribute to the development of neutralizing antibodies and vaccine strategies that will be our ultimate
defense against recurrence of this extraordinary pandemic. A rapid and robust scientific and medical response
of the type proposed by the NIAID and the academic community in this consortium is an essential element of a
broad response required to protect the health and well-being of all individuals, our health care system, and the
broader social structures that maintain global health and welfare.
项目总结/文摘
项目成果
期刊论文数量(0)
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David J Erle其他文献
Differential gene expression by integrin β7+ and β7- memory T helper cells
- DOI:
10.1186/1471-2172-5-13 - 发表时间:
2004-07-05 - 期刊:
- 影响因子:2.700
- 作者:
Madeleine W Rodriguez;Agnés C Paquet;Yee Hwa Yang;David J Erle - 通讯作者:
David J Erle
David J Erle的其他文献
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{{ truncateString('David J Erle', 18)}}的其他基金
Airway epithelial cell gene regulation: new mechanisms and therapeutic strategies
气道上皮细胞基因调控:新机制和治疗策略
- 批准号:
10586412 - 财政年份:2019
- 资助金额:
$ 179.79万 - 项目类别:
Airway epithelial cell gene regulation: new mechanisms and therapeutic strategies
气道上皮细胞基因调控:新机制和治疗策略
- 批准号:
10579268 - 财政年份:2019
- 资助金额:
$ 179.79万 - 项目类别:
Airway epithelial cell gene regulation: new mechanisms and therapeutic strategies
气道上皮细胞基因调控:新机制和治疗策略
- 批准号:
9915971 - 财政年份:2019
- 资助金额:
$ 179.79万 - 项目类别:
Airway epithelial cell gene regulation: new mechanisms and therapeutic strategies
气道上皮细胞基因调控:新机制和治疗策略
- 批准号:
10349455 - 财政年份:2019
- 资助金额:
$ 179.79万 - 项目类别:
Defining A Comprehensive Reference Profile of Circulating Human Extracellular RNA
定义循环人类细胞外 RNA 的综合参考谱
- 批准号:
8775079 - 财政年份:2014
- 资助金额:
$ 179.79万 - 项目类别:
Massively parallel identification of functional 3' UTR variants in asthma
哮喘功能性 3 UTR 变异的大规模并行鉴定
- 批准号:
8901295 - 财政年份:2014
- 资助金额:
$ 179.79万 - 项目类别:
Defining A Comprehensive Reference Profile of Circulating Human Extracellular RNA
定义循环人类细胞外 RNA 的综合参考谱
- 批准号:
9449991 - 财政年份:2014
- 资助金额:
$ 179.79万 - 项目类别:
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