Fluorescence tools that illuminate biology and inspire translation
Fluorescence tools that illuminate biology and inspire translation
批准号:
10372854
负责人:
Alanna Schepartz
金额:
$12.73万
依托单位国家:
美国
项目类别:
财政年份:
2020
资助国家:
美国
项目状态:
未结题
起止时间:
2020-02-01 至 2025-01-31
关键词:
AreaBindingBiologyCellsChemistryComplexDevelopmentDiseaseElementsFluorescenceFluorescence SpectroscopyFunctional disorderGoalsHealthHumanInfluentialsLaboratoriesMolecular AnalysisMolecular StructureNational Institute of General Medical SciencesOrganellesPropertyProteinsResearchTranslationsdesigninnovationmultidisciplinarynovelprogramstool
中文摘要
A.总结(1 R35 GM 134963)。了解蛋白质和细胞器的机制
功能和功能障碍需要动态分析分子结构和相互作用
在活细胞中。我的实验室的一个长期目标是开发工具,揭示这些功能
元素,并将其应用于发现新的重要生物学和分子,
或有影响力的财产。我被复杂的多学科问题所吸引,
催化令人兴奋的非增量进展。我们不仅致力于开发工具,
并以创新的方式加以应用。荧光光谱法的特点突出,
本文所述的两个研究项目。在这两种情况下,我们开发的荧光工具,
先前的NIGMS支持已经发现了有影响力的新生物学;该应用程序继续这一点
开发和扩展新生物学以造福人类健康。
英文摘要
A. Summary (1R35GM134963). Understanding the mechanisms of protein and organelle
function and dysfunction requires dynamic analysis of molecular structures and interactions
in live cells. A long-term goal of my laboratory is to develop tools that reveal these functional
elements and apply them to discover novel an significant biology and molecules with useful
or influential properties. I am drawn to complex, multi-disciplinary problems where chemistry
catalyzes exciting and non-incremental progress. We strive not simply to develop tools but
also apply them in innovative ways. Fluorescence spectroscopy features prominently in the
two research programs described herein. In both, fluorescent tools that we developed using
prior NIGMS support have uncovered influential new biology; this application continues this
development and expands the new biology to benefit human health.
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Fluorescence tools that illuminate biology and inspire translation
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批准号:10365915
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项目类别:
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资助金额:$69.04万
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财政年份:2020
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负责人:Alanna Schepartz
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依托单位:
Fluorescence tools that illuminate biology and inspire translation
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批准号:10091496
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项目类别:
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资助金额:$68.78万
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财政年份:2020
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负责人:Alanna Schepartz
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依托单位:
Fluorescence tools that illuminate biology and inspire translation
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批准号:10809483
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资助金额:$1.58万
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Fluorescence tools that illuminate biology and inspire translation
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资助金额:$69.04万
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Expanding the HIDE nanoscopy toolbox: More organelles, colors, and modalities
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批准号:10019809
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Repurposing the Ribosome for Exotic Polymers
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批准号:9311712
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Repurposing the Ribosome for Exotic Polymers
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批准号:9999711
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资助金额:$6.67万
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Directing the Mediator Complex: Bivalent approaches to Reconstituting or Inhibiti
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批准号:8895755
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资助金额:$13.19万
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Foldamers: Novel Ligands for Diverse Protein Surfaces
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批准号:7928434
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Small Molecule Tools to Image and Understand Sophisticated Protein Function
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批准号:9276914
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资助金额:$18.98万
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Surveying protein partnerships and assembly with bipartite tetracysteine display
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Surveying protein partnerships and assembly with bipartite tetracysteine display
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依托单位:
Small Molecule Tools to Image Sophisticated Protein Function
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批准号:8243508
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资助金额:$31.25万
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财政年份:2008
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负责人:Alanna Schepartz
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依托单位:
Small Molecule Tools to Image Sophisticated Protein Function
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批准号:8445421
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资助金额:$30.15万
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财政年份:2008
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依托单位:
Small Molecule Tools to Image Sophisticated Protein Function
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批准号:8115641
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资助金额:$28.86万
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财政年份:2008
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负责人:Alanna Schepartz
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依托单位:
Small Molecule Tools to Image and Understand Sophisticated Protein Function
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批准号:8887797
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资助金额:$29.8万
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财政年份:2008
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负责人:Alanna Schepartz
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依托单位:
Small Molecule Tools to Image Sophisticated Protein Function
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批准号:8641384
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项目类别:
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资助金额:$31.17万
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财政年份:2008
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负责人:Alanna Schepartz
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依托单位:
STRUCTURE OF HEXAMERIC BUNDLES OF BETA-AMINO ACID PEPTIDE U1F
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批准号:7357748
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资助金额:$1.36万
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财政年份:2006
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负责人:Alanna Schepartz
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依托单位:
Foldamers: Novel Ligands for Diverse Protein Surfaces
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批准号:8536825
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项目类别:
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资助金额:$32.6万
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财政年份:2005
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负责人:Alanna Schepartz
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Foldamers: Novel Ligands for Diverse Protein Surfaces
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批准号:7270020
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资助金额:$41.77万
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财政年份:2005
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负责人:Alanna Schepartz
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依托单位:
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