Spatial patterning in interglomerular inhibitory circuits

摘要 嗅球是研究感觉神经生理学和神经功能的一个很好的模型系统 信息编码许多证据间接表明，嗅觉活动的空间模式 灯泡是重要的编码嗅觉信息，但活动的空间模式之间的关系， 在灯泡和嗅觉刺激空间仍有待充分阐明。感觉系统的侧抑制是 与感官形态的刺激空间有关。在嗅球的小球层，外侧 肾小球之间的抑制性相互作用主要由短轴突细胞介导。这一提议扩大了 先前的工作表明肾小球间抑制是稀疏的和选择性的，以直接测试可能的 这种特异性的机制。两个假说有关的特异性气味诱发抑制的检查 通过光学记录嗅球、二尖瓣和簇状细胞的输出神经元的活动， 来自短轴突细胞。本项目将描述肾小球间的功能和空间特性， 通过刺激嗅觉活性的气味和光遗传学技术抑制。的结果予以 实验将产生对肾小球间抑制作用和短轴突细胞网络的新认识。

Abstract The olfactory bulb is an excellent model system for the study of sensory neurophysiology and neural information coding. Many lines of evidence indirectly suggest that spatial patterning of activity in the olfactory bulb is important for encoding olfactory information, but the relationship between the spatial patterns of activity in the bulb and olfactory stimulus space remain to be fully elucidated. Lateral inhibition in sensory systems is related to the stimulus space of the sensory modality. In the glomerular layer of the olfactory bulb, lateral inhibitory interactions between glomeruli are primarily mediated by short axon cells. This proposal expands on previous work demonstrating that interglomerular inhibition is sparse and selective to directly test possible mechanisms for this specificity. Two hypotheses relating to specificity of odor evoked inhibition are examined through optical recordings of activity from the output neurons of the olfactory bulb, mitral and tufted cells, and from short axon cells. This project will characterize the functional and spatial properties of interglomerular inhibition by stimulating olfactory activity with odors and optogenetic techniques. The results of these experiments will yield new insight into the role of interglomerular inhibition and the short axon cell network.