COBRE for Skeletal Health & Repair

总括 7.项目摘要/摘要 骨骼健康与修复生物医学研究卓越中心(COBRE)的长期目标 是建立一个多学科的翻译研究中心，专注于发现软骨的机制 在这方面，儿童基金会致力于预防和治疗关节疾病以及制定预防和治疗战略。从科布雷开始的八年 在此之前，已有7名完整的项目调查人员获得了R01或R01等值的联邦拨款，并从 Cobre培训计划，并发表了240多篇同行评议文章，包括里程碑式的 自然界、分子细胞和PNA的发现。所有20名目标初级调查员都收到了 作为首席调查员，已经建立了新的最先进的实验室和核心设施 生物工程、成像、分子生物学和纳米医学。第三阶段Cobre的主要目标是 加强科布雷研究基础设施并将其转变为具有竞争力、独立性和自主性的 持续卓越的学术中心-布朗肌肉骨骼和运动科学中心(BCMMS) 五年了。为实现这一主要目标，提出了以下四个具体目标。目标1，行政管理 在翻译研究方面提供强有力的领导，评估技术核心的表现 资源和设施，指导试点项目计划中的指导工作，并实施COBRE 过渡计划；目标2，生物工程核心增强了交互式研究环境，并提供 细胞、组织和器官水平生物力学测试的独特资源；目标3，成像，分子 生物学和纳米医学核心增强了从工作台到床边的转换研究，提供了关键的 在小动物活体成像分析方面的专业知识和设备，并促进新型 用于诊断和治疗的纳米材料输送工具；以及AIM 4，试点项目计划导师a 包括临床医生在内的多学科肌肉骨骼研究的新一代研究人员， 生物学家和工程师，促进研究合作，维持强大的研究环境 在科布雷的前两个阶段开发。我们的愿景是，通过维持和过渡已建立的高- 一流的研究基础设施，我们将使临床医生能够与基础研究科学家并肩工作， 初级调查人员和高级调查人员，以及未来长期拥有生物工程师的生物学家。

Overall 7. Project Summary/Abstract The long-term goal of the Center of Biomedical Research Excellence (COBRE) for Skeletal Health and Repair is to develop a multi-disciplinary translational research center focusing on discovering mechanisms of cartilage joint diseases and developing prevention and treatment strategies. Since the start of the COBRE eight years ago, seven full project investigators have received R01 or R01-equivalent federal grants and “graduated” from the COBRE training program, and published more than 240 peer-reviewed articles including landmark discoveries in Nature, Molecular Cell, and PNAS. All twenty target junior investigators have received exramural funding as Principal Investigator, and new state-of-the-art laboratories and core facilities have been built in bioengineering, imaging, molecular biology and nanomedicine. The main objective of the Phase III COBRE is to strengthen and transition the COBRE research infrastructure into a competitive, independent, and self- sustaining academic center of excellence-Brown Center of Musculoskeletal and Motion Sciences (BCMMS) in five years. To achieve this main objective, four specific aims are proposed as follows. Aim 1, Administrative Core provides strong leadership in translational research, evaluates the performance of technical Core Resources and Facilities, guides mentoring efforts in the Pilot Projects Program, and implements the COBRE transitioning plan; Aim 2, Bioengineering Core enhances an interactive research environment and provides the unique resources of biomechanical testing at the cell, tissue, and organ levels; Aim 3, Imaging, Molecular Biology, and Nanomedicine Core enhances translational research from bench to bedside, provides critical expertise and equipment in small animal live imaging analysis, and facilitates development of novel nanomaterial delivery vehicles for diagnostics and therapeutics; and Aim 4, Pilot Projects Program mentors a new generation of researchers in multiple disciplines of musculoskeletal research including clinicians, biologists, and engineers, facilitates research collaborations, and sustains the strong research environment developed in the first two phases of COBRE. Our vision is, by sustaining and transitioning the established high- caliber research infrastructure, we will enable clinicians working side-by-side with basic research scientists, junior investigators with senior investigators, and biologists with bioengineers for a long term into the future.