COBRE for Skeletal Health & Repair

COBRE 促进骨骼健康

• 批准号: 10263335
• 负责人: QIAN CHEN
• 金额: $ 114.27万
• 依托单位: RHODE ISLAND HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-01 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10263335
• 关键词: American; Animals; Basic Science; Benchmarking; Biomechanics; Biomedical Engineering; Caliber; Cartilage; Cartilage Diseases; Cells; Center for Translational Science Activities; Centers of Research Excellence; Collaborations; Core Facility; Degenerative polyarthritis; Development; Diagnostic; Discipline; Engineering; Environment; Equipment; Faculty; Funding; Future; Generations; Goals; Grant; Health; Hospitals; Image; Infrastructure; International; Joints; Laboratories; Leadership; Mentors; Molecular; Molecular Biology; Motion; Musculoskeletal; Musculoskeletal Diseases; Nature; Organ; Peer Review; Performance; Phase; Pilot Projects; Prevention; Prevention strategy; Principal Investigator; Publishing; Research; Research Infrastructure; Research Peer Review; Research Personnel; Research Project Grants; Resources; Rhode Island; Science; Scientist; Services; Side; Testing; Therapeutic; Tissues; Training; Training Programs; Translational Research; United States National Institutes of Health; Universities; Vision; arthropathies; bench to bedside; disability; interdisciplinary approach; laboratory facility; multidisciplinary; nanomaterials; nanomedicine; novel; programs; recruit; repaired; skeletal; success; translational approach; treatment strategy

Overall 7. Project Summary/Abstract The long-term goal of the Center of Biomedical Research Excellence (COBRE) for Skeletal Health and Repair is to develop a multi-disciplinary translational research center focusing on discovering mechanisms of cartilage joint diseases and developing prevention and treatment strategies. Since the start of the COBRE eight years ago, seven full project investigators have received R01 or R01-equivalent federal grants and “graduated” from the COBRE training program, and published more than 240 peer-reviewed articles including landmark discoveries in Nature, Molecular Cell, and PNAS. All twenty target junior investigators have received exramural funding as Principal Investigator, and new state-of-the-art laboratories and core facilities have been built in bioengineering, imaging, molecular biology and nanomedicine. The main objective of the Phase III COBRE is to strengthen and transition the COBRE research infrastructure into a competitive, independent, and self- sustaining academic center of excellence-Brown Center of Musculoskeletal and Motion Sciences (BCMMS) in five years. To achieve this main objective, four specific aims are proposed as follows. Aim 1, Administrative Core provides strong leadership in translational research, evaluates the performance of technical Core Resources and Facilities, guides mentoring efforts in the Pilot Projects Program, and implements the COBRE transitioning plan; Aim 2, Bioengineering Core enhances an interactive research environment and provides the unique resources of biomechanical testing at the cell, tissue, and organ levels; Aim 3, Imaging, Molecular Biology, and Nanomedicine Core enhances translational research from bench to bedside, provides critical expertise and equipment in small animal live imaging analysis, and facilitates development of novel nanomaterial delivery vehicles for diagnostics and therapeutics; and Aim 4, Pilot Projects Program mentors a new generation of researchers in multiple disciplines of musculoskeletal research including clinicians, biologists, and engineers, facilitates research collaborations, and sustains the strong research environment developed in the first two phases of COBRE. Our vision is, by sustaining and transitioning the established high- caliber research infrastructure, we will enable clinicians working side-by-side with basic research scientists, junior investigators with senior investigators, and biologists with bioengineers for a long term into the future.

整体 7.项目总结/摘要 生物医学研究卓越中心（COBRE）的长期目标是骨骼健康和修复 是发展一个多学科的转化研究中心，重点是发现软骨的机制， 关节疾病和制定预防和治疗战略。自从眼镜蛇计划开始以来， 前，七个完整的项目研究人员已收到R 01或R 01相当于联邦赠款和“毕业”从 COBRE培训计划，并发表了240多篇同行评议的文章，包括里程碑式的 《自然》、《分子细胞》和《美国国家科学院院刊》上的发现。所有20名目标初级调查员都接受了 作为主要研究者，新的最先进的实验室和核心设施已经建成， 生物工程、成像、分子生物学和纳米医学。COBRE第三阶段的主要目标是 加强和过渡的COBRE研究基础设施，成为一个有竞争力的，独立的，自我的， 布朗肌肉骨骼和运动科学中心（BCMMS） 五年为实现这一主要目标，提出了以下四个具体目标。目标1，行政 核心在转化研究中提供强有力的领导，评估技术核心的性能 资源和设施，指导试点项目计划中的辅导工作，并实施COBRE 过渡计划;目标2，生物工程核心增强了互动的研究环境，并提供了 在细胞、组织和器官水平进行生物力学测试的独特资源;目标3，成像，分子 生物学和纳米医学核心增强了从实验室到床边的转化研究， 在小动物活体成像分析方面的专业知识和设备，并促进开发新的 用于诊断和治疗的纳米材料运载工具;目标4，试点项目计划导师 新一代的研究人员在多个学科的肌肉骨骼研究，包括临床医生， 生物学家和工程师，促进研究合作，并维持强大的研究环境 在COBRE的前两个阶段开发的。我们的愿景是，通过维持和过渡既定的高- 口径的研究基础设施，我们将使临床医生与基础研究科学家并肩工作， 初级研究员和高级研究员，生物学家和生物工程师，在未来的很长一段时间里。