COBRE for Skeletal Health & Repair
COBRE 促进骨骼健康
基本信息
- 批准号:10263335
- 负责人:
- 金额:$ 114.27万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2017
- 资助国家:美国
- 起止时间:2017-09-01 至 2024-08-31
- 项目状态:已结题
- 来源:
- 关键词:AmericanAnimalsBasic ScienceBenchmarkingBiomechanicsBiomedical EngineeringCaliberCartilageCartilage DiseasesCellsCenter for Translational Science ActivitiesCenters of Research ExcellenceCollaborationsCore FacilityDegenerative polyarthritisDevelopmentDiagnosticDisciplineEngineeringEnvironmentEquipmentFacultyFundingFutureGenerationsGoalsGrantHealthHospitalsImageInfrastructureInternationalJointsLaboratoriesLeadershipMentorsMolecularMolecular BiologyMotionMusculoskeletalMusculoskeletal DiseasesNatureOrganPeer ReviewPerformancePhasePilot ProjectsPreventionPrevention strategyPrincipal InvestigatorPublishingResearchResearch InfrastructureResearch Peer ReviewResearch PersonnelResearch Project GrantsResourcesRhode IslandScienceScientistServicesSideTestingTherapeuticTissuesTrainingTraining ProgramsTranslational ResearchUnited States National Institutes of HealthUniversitiesVisionarthropathiesbench to bedsidedisabilityinterdisciplinary approachlaboratory facilitymultidisciplinarynanomaterialsnanomedicinenovelprogramsrecruitrepairedskeletalsuccesstranslational approachtreatment strategy
项目摘要
Overall
7. Project Summary/Abstract
The long-term goal of the Center of Biomedical Research Excellence (COBRE) for Skeletal Health and Repair
is to develop a multi-disciplinary translational research center focusing on discovering mechanisms of cartilage
joint diseases and developing prevention and treatment strategies. Since the start of the COBRE eight years
ago, seven full project investigators have received R01 or R01-equivalent federal grants and “graduated” from
the COBRE training program, and published more than 240 peer-reviewed articles including landmark
discoveries in Nature, Molecular Cell, and PNAS. All twenty target junior investigators have received exramural
funding as Principal Investigator, and new state-of-the-art laboratories and core facilities have been built in
bioengineering, imaging, molecular biology and nanomedicine. The main objective of the Phase III COBRE is
to strengthen and transition the COBRE research infrastructure into a competitive, independent, and self-
sustaining academic center of excellence-Brown Center of Musculoskeletal and Motion Sciences (BCMMS) in
five years. To achieve this main objective, four specific aims are proposed as follows. Aim 1, Administrative
Core provides strong leadership in translational research, evaluates the performance of technical Core
Resources and Facilities, guides mentoring efforts in the Pilot Projects Program, and implements the COBRE
transitioning plan; Aim 2, Bioengineering Core enhances an interactive research environment and provides the
unique resources of biomechanical testing at the cell, tissue, and organ levels; Aim 3, Imaging, Molecular
Biology, and Nanomedicine Core enhances translational research from bench to bedside, provides critical
expertise and equipment in small animal live imaging analysis, and facilitates development of novel
nanomaterial delivery vehicles for diagnostics and therapeutics; and Aim 4, Pilot Projects Program mentors a
new generation of researchers in multiple disciplines of musculoskeletal research including clinicians,
biologists, and engineers, facilitates research collaborations, and sustains the strong research environment
developed in the first two phases of COBRE. Our vision is, by sustaining and transitioning the established high-
caliber research infrastructure, we will enable clinicians working side-by-side with basic research scientists,
junior investigators with senior investigators, and biologists with bioengineers for a long term into the future.
整体
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
QIAN CHEN其他文献
QIAN CHEN的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('QIAN CHEN', 18)}}的其他基金
Cell Senescence Regulating Osteoarthritis Progression: Sex-dependent Mechanisms
细胞衰老调节骨关节炎进展:性别依赖性机制
- 批准号:
10567551 - 财政年份:2023
- 资助金额:
$ 114.27万 - 项目类别:
Developing Nanopieces, a Platform RNAi Delivery Technology for Treatment of Multiple Diseases
开发 Nanopieces,一种用于治疗多种疾病的 RNAi 传递技术平台
- 批准号:
9777769 - 财政年份:2020
- 资助金额:
$ 114.27万 - 项目类别:
Repressing Retrotransposon LINE-1: New Concepts for Osteoarthritis Treatment
抑制逆转录转座子 LINE-1:骨关节炎治疗的新概念
- 批准号:
9912431 - 财政年份:2019
- 资助金额:
$ 114.27万 - 项目类别:
Repressing Retrotransposon LINE-1: New Concepts for Osteoarthritis Treatment
抑制逆转录转座子 LINE-1:骨关节炎治疗的新概念
- 批准号:
10019329 - 财政年份:2019
- 资助金额:
$ 114.27万 - 项目类别:
相似海外基金
The earliest exploration of land by animals: from trace fossils to numerical analyses
动物对陆地的最早探索:从痕迹化石到数值分析
- 批准号:
EP/Z000920/1 - 财政年份:2025
- 资助金额:
$ 114.27万 - 项目类别:
Fellowship
Animals and geopolitics in South Asian borderlands
南亚边境地区的动物和地缘政治
- 批准号:
FT230100276 - 财政年份:2024
- 资助金额:
$ 114.27万 - 项目类别:
ARC Future Fellowships
The function of the RNA methylome in animals
RNA甲基化组在动物中的功能
- 批准号:
MR/X024261/1 - 财政年份:2024
- 资助金额:
$ 114.27万 - 项目类别:
Fellowship
Ecological and phylogenomic insights into infectious diseases in animals
对动物传染病的生态学和系统发育学见解
- 批准号:
DE240100388 - 财政年份:2024
- 资助金额:
$ 114.27万 - 项目类别:
Discovery Early Career Researcher Award
Zootropolis: Multi-species archaeological, ecological and historical approaches to animals in Medieval urban Scotland
Zootropolis:苏格兰中世纪城市动物的多物种考古、生态和历史方法
- 批准号:
2889694 - 财政年份:2023
- 资助金额:
$ 114.27万 - 项目类别:
Studentship
Using novel modelling approaches to investigate the evolution of symmetry in early animals.
使用新颖的建模方法来研究早期动物的对称性进化。
- 批准号:
2842926 - 财政年份:2023
- 资助金额:
$ 114.27万 - 项目类别:
Studentship
Study of human late fetal lung tissue and 3D in vitro organoids to replace and reduce animals in lung developmental research
研究人类晚期胎儿肺组织和 3D 体外类器官在肺发育研究中替代和减少动物
- 批准号:
NC/X001644/1 - 财政年份:2023
- 资助金额:
$ 114.27万 - 项目类别:
Training Grant
RUI: Unilateral Lasing in Underwater Animals
RUI:水下动物的单侧激光攻击
- 批准号:
2337595 - 财政年份:2023
- 资助金额:
$ 114.27万 - 项目类别:
Continuing Grant
RUI:OSIB:The effects of high disease risk on uninfected animals
RUI:OSIB:高疾病风险对未感染动物的影响
- 批准号:
2232190 - 财政年份:2023
- 资助金额:
$ 114.27万 - 项目类别:
Continuing Grant
A method for identifying taxonomy of plants and animals in metagenomic samples
一种识别宏基因组样本中植物和动物分类的方法
- 批准号:
23K17514 - 财政年份:2023
- 资助金额:
$ 114.27万 - 项目类别:
Grant-in-Aid for Challenging Research (Exploratory)