Preventing Obesity in Preterm Infants

预防早产儿肥胖

• 批准号: 10370657
• 负责人: Catherine O Buck
• 金额: $ 16.68万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-01 至 2027-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10370657
• 关键词: 2 year old; Adipose tissue; Adolescence; Adult; Affect; Age; Biological Markers; Biometry; Biostatistical Methods; Birth; Birth Weight; Blood Pressure; Body Composition; Body fat; Body mass index; Cardiometabolic Disease; Child; Childhood; Clinical Research; Clinical Trials; Data; Development; Development Plans; Diabetes Mellitus; Dietary Intervention; Endocrinology; Energy Metabolism; Exposure to; Fatty acid glycerol esters; Future; Gestational Age; Gestational Diabetes; Goals; Growth; Growth and Development function; Hospitalization; Hospitals; Infant; Intervention; Lead; Leptin; Life; Longitudinal Studies; Magnetic Resonance Imaging; Mentors; Metabolic syndrome; Metabolism; Monitor; Mothers; Newborn Infant; Nutritional; Obesity; Pattern; Perinatal; Perinatal Epidemiology; Perinatal Exposure; Pharmacotherapy; Phenotype; Pregnancy; Premature Birth; Premature Infant; Prospective cohort; Race; Research; Research Design; Research Methodology; Research Personnel; Research Project Grants; Risk; Role; Skinfold Thickness; Tissues; Training; United States; Visceral; Vulnerable Populations; Weight; Weight Gain; Woman; adiponectin; candidate marker; cardiometabolism; career development; cost estimate; critical period; early childhood; early detection biomarkers; epidemiology study; high risk population; hormone metabolism; infant nutrition; insulin sensitivity; maternal diabetes; maternal obesity; newborn adiposity; non-diabetic; obesity development; obesity in children; obesity prevention; obesity risk; offspring; perinatal environment; perinatal period; postnatal; prepregnancy; prevent; prospective; public health relevance; risk stratification; sex; sociodemographic factors; subcutaneous; therapy development

PROJECT SUMMARY The objective of this research project is to determine if indicators of adipose tissue development and metabolism are candidate biomarkers to identify preterm infants at risk of childhood obesity and cardiometabolic abnormalities. Infants born moderately preterm, between 32- and 36-weeks of gestational age, have 20% higher odds of obesity and cardiometabolic disease in adulthood compared with those born at term. Moderate preterm birth accounts for 8% of all births, or approximately 300,000 children born in the United States each year. Factors that may contribute to obesity risk among preterm infants include developmental re- programming due to perinatal exposure to maternal obesity and diabetes. Preliminary data shows that moderate preterm infants of mothers with diabetes have greater in-hospital growth over an average of 9 days compared with infants of non-diabetic mothers, after adjustment for gestational age, sex, and race. Accelerated growth in these infants may be due to alterations in the development, metabolism, and localization of adipose tissue. In a prospective cohort of moderately preterm infants, the aims of this project are: To determine the effect of maternal obesity and gestational diabetes on the development of adiposity at term corrected age and its association with adipose tissue metabolism biomarkers at birth (Aim 1) and to identify the role of early body composition assessments by magnetic resonance imaging and adipose tissue metabolism biomarkers at birth in predicting early childhood growth and development of adiposity and cardiometabolic abnormalities at age 2 years (Aim 2). Identification of these perinatal biomarkers is critical in the ability to risk-stratify infants at heightened risk of obesity and cardiometabolic abnormalities, and for the future development of interventions to optimize healthy growth and reduce obesity among preterm infants. Dr. Buck is a neonatologist whose long-term goal is to lead independent research examining perinatal risks that influence growth and development among preterm infants. The career development plan for this proposal builds upon Dr. Buck's prior training in epidemiology and clinical research methods through graduate-level coursework and mentored training in longitudinal study design, advanced biostatistical methods, biomarker and body composition assessment, and clinical trial study conduction. Dr. Buck has assembled a strong, committed team of mentors and advisors with expertise in infant nutrition, pediatric endocrinology, perinatal epidemiology, and biostatistics to help guide her successful transition to becoming an independent investigator, optimizing healthy growth and development of preterm infants and minimizing the development of obesity and cardiometabolic abnormalities in this vulnerable population.

项目总结