Predicting glymphatic function via PET/MR imaging biomarkers and Nose to Brain contrast delivery
通过 PET/MR 成像生物标志物和鼻到脑对比剂输送来预测类淋巴功能
基本信息
- 批准号:10370078
- 负责人:
- 金额:$ 41.79万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-02-01 至 2025-01-31
- 项目状态:未结题
- 来源:
- 关键词:3-DimensionalAddressAgingAlzheimer&aposs DiseaseAmyloid beta-ProteinAnatomyAutopsyBiological MarkersBlood CirculationBrainCellsCephalicCerebrospinal FluidCervical lymph node groupClinicClinicalContrast MediaDataData SetDementiaDetectionDevelopmentDiagnosisDiagnosticDiseaseDisease modelEarly DiagnosisEvaluationFDA approvedFluorescence MicroscopyFunctional disorderFutureGadoliniumGoalsGoldHepaticHistologicHumanImageImaging DeviceImmuneImmunohistochemistryImpaired cognitionIncidenceIndividualInjectionsIntercellular FluidInterventionInvestigationLabelLigationLymphaticLymphatic SystemLymphatic clearanceLymphatic functionMagnetic Resonance ImagingMeasuresMediatingMeningeal lymphatic systemMeningesMethodsModalityModelingNerve DegenerationNeuraxisNeurodegenerative DisordersNoseOutcomePathologicPathologyPatient CarePatientsPlayPositron-Emission TomographyPreventive careProteinsRadioactiveRattusReportingResearchRodentRoleRouteSystemTechniquesTestingTracerTranslationsUnited StatesWaste Productsagedbasebrain pathwaybrain tissueclinical imagingcostcribriform platefluorophorefunctional disabilityglymphatic clearanceglymphatic functionglymphatic systemhuman old age (65+)imaging agentimaging biomarkerimaging modalityin vivo imaginginsightlymph flowlymphatic vesselmolecular imagingnervous system disorderneuropathologyneurotoxicneurotoxicitynon-invasive imagingpathological agingperineuralperivascular channelsphysical modelpre-clinicalprotein aggregationquantitative imagingradiotracertoolwasting
项目摘要
PROJECT TITLE: Predicting glymphatic function via PET/MR imaging biomarkers and Nose to Brain
contrast delivery
PROJECT ABSTRACT: The recently identified glymphatic system, which modulates exchange of the brain’s
interstitial fluid and cerebrospinal fluid, has been shown to play a major role in the clearance of waste products
from the brain. Individuals with dementia or old age show diminished glymphatic clearance, which is
hypothesized to contribute to protein aggregation, neurotoxicity, and cognitive decline. The impact of changes
in glymphatic function have not been comprehensively investigated, as clinical methods to evaluate the
glymphatic system are lacking. A sensitive and noninvasive imaging tool for evaluation of glymphatic function is
clearly needed. This proposal addresses this need by testing sensitive, non-invasive methods for quantifying
brain waste clearance that are readily translatable to the clinic. Nose to brain (N2B) delivery is a useful tool for
direct delivery to the brain and is hypothesized to utilize glymphatic vessels for distribution throughout the brain
tissue. We will test whether N2B PET tracer clearance from the brain visualized by noninvasive PET/MRI
provides meaningful information about glymphatic function, and correlate with known anatomical changes by
fluorescence microscopy. Our PET approach will be compared to the MRI current gold standard for glymphatic
imaging and tested in physical and pathological models of glymphatic alterations. If successful, this study could
provide a tool for early detection of diminished glymphatic function before the onset of neurotoxic pathology.
项目标题:通过PET/MR成像生物标志物和鼻-脑预测胶质淋巴功能
造影剂递送
项目摘要:最近发现的胶质淋巴系统,它调节大脑的
间质液和脑脊髓液,已被证明在废物的清除中发挥重要作用
从大脑中。患有痴呆症或老年的个体显示出减少的胶质淋巴清除,
假设其有助于蛋白质聚集、神经毒性和认知能力下降。变化的影响
在胶质淋巴功能尚未全面调查,作为临床方法来评估
glymphatic系统缺乏。评价胶质淋巴功能的一种敏感和非侵入性的成像工具是
显然需要。该提案通过测试敏感的、非侵入性的定量方法来满足这一需求。
大脑废物清除,很容易转移到诊所。鼻到脑(N2 B)递送是一种有用的工具,
直接递送至大脑,并假设利用胶质淋巴管分布于整个大脑
组织.我们将测试N2 B PET示踪剂从脑中的清除是否通过无创PET/MRI可视化
提供有关胶质淋巴功能的有意义的信息,并通过以下方式与已知的解剖学变化相关联:
荧光显微镜我们的PET方法将与MRI目前的胶质淋巴瘤诊断金标准进行比较。
成像并在胶质淋巴改变的物理和病理模型中测试。如果成功,这项研究可以
提供了一种在神经毒性病理学发作之前早期检测胶质淋巴功能减弱的工具。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Kurt R Zinn其他文献
Bioluminescence-based visualization of CD4 T cell dynamics using a T lineage-specific luciferase transgenic model1
- DOI:
10.1186/1471-2172-10-44 - 发表时间:
2009-08-03 - 期刊:
- 影响因子:2.700
- 作者:
Joseph H Chewning;Kari J Dugger;Tandra R Chaudhuri;Kurt R Zinn;Casey T Weaver - 通讯作者:
Casey T Weaver
Kurt R Zinn的其他文献
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{{ truncateString('Kurt R Zinn', 18)}}的其他基金
IN VIVO REPORTER SYSTEM FOR IMAGING GENE TRANSFER
用于成像基因转移的体内报告系统
- 批准号:
2899971 - 财政年份:1999
- 资助金额:
$ 41.79万 - 项目类别:
IN VIVO REPORTER SYSTEM FOR IMAGING GENE TRANSFER
用于成像基因转移的体内报告系统
- 批准号:
6173762 - 财政年份:1999
- 资助金额:
$ 41.79万 - 项目类别:
IN VIVO REPORTER SYSTEM FOR IMAGING GENE TRANSFER
用于成像基因转移的体内报告系统
- 批准号:
6376999 - 财政年份:1999
- 资助金额:
$ 41.79万 - 项目类别:
IN VIVO REPORTER SYSTEM FOR IMAGING GENE TRANSFER
用于成像基因转移的体内报告系统
- 批准号:
6513454 - 财政年份:1999
- 资助金额:
$ 41.79万 - 项目类别:
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