Affective Executive Functioning as a Mechanism of Mindfulness-Based Cognitive Therapy: A Pilot Randomized Controlled Trial

情感执行功能作为基于正念的认知治疗的机制：一项随机对照试验

• 批准号: 10370848
• 负责人: Morganne A Kraines
• 金额: $ 17.33万
• 依托单位: BUTLER HOSPITAL (PROVIDENCE, RI)
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-01-01 至 2026-12-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10370848
• 关键词: Address; Adherence; Adult; Affect; Affective; Attention; Back; Behavior; Clinical Trials; Code; Cognition; Cognitive; Communities; Computers; Conscious; Data Analyses; Depressed mood; Disease; Educational workshop; Emotional; Environment; Executive Dysfunction; Financial Hardship; General Population; Goals; Grant; Health; Health education; Home; Hospitals; Impairment; Individual; Institution; Intervention; Knowledge; Literature; Major Depressive Disorder; Measures; Mental Depression; Mental Health; Mentors; Methods; Mind-Body Intervention; Mindfulness Training; Modeling; Monitor; Mood Disorders; National Center for Complementary and Integrative Health; Neurocognitive; Outcome; Participant; Patients; Personal Satisfaction; Process; Randomized; Randomized Controlled Trials; Reading; Relapse; Research; Research Ethics; Research Methodology; Research Personnel; Risk; Schedule; Services; Severities; Stimulus; Structure; System; Testing; Time; Training; Training Support; Treatment Protocols; Universities; Update; Work; arm; attentional bias; base; cognitive function; daily functioning; depressive symptoms; efficacious treatment; emotional stimulus; executive function; experience; improved; information processing; innovation; meetings; mental set; mindfulness; mindfulness based cognitive therapy; mindfulness intervention; novel; operation; prevent; programs; psychoeducational; recruit; reduce symptoms; research and development; resilience; skills; symposium; theories; training opportunity

PROJECT SUMMARY/ABSTRACT Mindfulness-Based Cognitive Therapy (MBCT) is an efficacious treatment for patients with symptoms of depression. However, the processes by which MBCT achieves its outcomes are not well understood. Drawing on literature on basic cognitive functioning and cognitive biases in depression, this K23 will use a randomized controlled trial to test the effect of MBCT vs. Health Education (HE) on affective inhibition (an important component of executive functioning (EF)), and a possible mechanism of action by which MBCT has an impact on depression symptoms. As a secondary aim, this project will also test the effect of MBCT vs. HE on affective updating and affective shifting (two remaining components of EF). In exploratory analyses, we will examine whether depression symptom severity covaries with change in affective EF (i.e., affective inhibition, shifting, and updating) overtime, and whether adherence to the treatment protocol predicts endpoint EF. To accomplish these goals, 76 adult participants with elevated depression symptoms will be recruited from the community and will be randomized to either an 8-week MBCT course at the Mindfulness Center at Brown University or an 8-week Psychoeducational Health Education Class (i.e., a control arm). Participants will complete validated computer-based tasks of affective EF at 5-assessments, 2 before, 2 during, and 1 after, the 8-week MBCT or HE programs. This project directly addresses NCCIH’s objective to advance the understanding of mechanisms through which mind and body approaches affect health, resilience and well-being. This project will directly address the candidate’s training goals of gaining clinical trials methods experience with mood disorders, expanding knowledge of mindfulness-based interventions (specifically MBCT), gain knowledge in neurocognitive assessment of individuals with depression symptoms, receive training in repeated longitudinal assessment, and further develop professional development, research ethics, and grants management skills. The candidate will complete a number of formal and informal activities (e.g., courses, workshops, conferences, directed readings, and regularly scheduled meetings with mentors) to meet the training goals. These training goals will assist the candidate to become a successful independent investigator examining cognitive mechanisms of mind-body interventions for depression and related disorders. The Mindfulness Center at Brown University and Butler Hospital are the ideal environments for this project, as they are leading institutions in clinical trials research and mindfulness-based interventions, with numerous opportunities for training and support services embedded within the systems.

项目摘要/摘要 基于正念的认知疗法（MBCT）是抑郁症状患者的有效治疗方法。但是，MBCT实现其结果的过程尚不清楚。该K23借鉴了有关抑郁症的基本认知功能和认知偏见的文献，将使用一项随机对照试验来测试MBCT与健康教育（HE）对情感抑制的影响（执行功能的重要组成部分（EF）），以及MBCT的可能作用机制对抑郁症状有影响。作为次要目标，该项目还将测试MBCT与他对情感更新和情感转移的影响（EF的剩余两个组成部分）。在探索性分析中，我们将检查抑郁症状严重程度协方差是否随着情感EF的变化（即情感抑制，转移和更新）是否加班，以及对治疗方案的遵守是否预测终点EF。为了实现这些目标，将从社区招募76名患有抑郁症状升高的成年参与者，并将在布朗大学的正念中心或为期8周的心理教育健康教育班（即控制臂）随机分为8周的MBCT课程。参与者将完全验证5个评估的情感EF的基于计算机的情感EF任务，2，在2和1之后，为8周的MBCT或HE计划。该项目直接解决了NCCIH的目标，以促进对心理和身体方法影响健康，韧性和福祉的机制的理解。该项目将直接解决候选人的培训目标，即获得情绪障碍的临床试验方法经验，扩大基于正念的干预措施的知识（特别是MBCT），在抑郁症状症状的个体的神经认知评估中获得知识，在反复纵向评估中接受培训，以及进一步的纵向评估以及进一步的发展专业发展，研究道德，研究道德和管理技能。候选人将完成许多正式和非正式活动（例如，课程，讲习班，会议，定向阅读以及与导师的定期会议），以实现培训目标。这些培训目标将有助于候选人成为成功的独立研究者，研究抑郁症和相关疾病的心身干预的认知机制。布朗大学和巴特勒医院的正念中心是该项目的理想环境，因为它们是临床试验研究和基于正念的干预措施的领导机构，并且在系统中嵌入了许多培训和支持服务的机会。