The Study of the Environment and Alzheimer's disease and related Dementias (SEAD)
环境与阿尔茨海默病和相关痴呆症的研究 (SEAD)
基本信息
- 批准号:10371214
- 负责人:
- 金额:$ 66.65万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-03-15 至 2026-02-28
- 项目状态:未结题
- 来源:
- 关键词:AddressAffectAlzheimer&aposs DiseaseAlzheimer&aposs disease related dementiaAlzheimer&aposs disease riskAmericanAnimal ModelBehavioralBiologicalBiological MarkersBiologyBloodCadmiumCase-Control StudiesChemicalsClinicalCognitionCohort StudiesComplexDataDevelopmentDietDiscriminationEarly InterventionEnvironmentEnvironmental ExposureEnvironmental Risk FactorEtiologyEvaluationExposure toFutureGeneticGenotypeGoalsHumanIndividualInfectionInterventionLeadLife StyleLinkMeasurementMeasuresMedicareModelingModernizationNational Health and Nutrition Examination SurveyNational Institute on AgingNeurodegenerative DisordersNeurotoxinsParticipantPoliciesPopulationPrecision HealthPrevalencePreventionProspective cohort studyPublic HealthRecommendationResearchRiskRisk FactorsRoleScientific Advances and AccomplishmentsStrategic PlanningTestingTimeToxic Environmental SubstancesUnited StatesUrineVulnerable Populationsabeta depositionadvanced diseasebasebonechronic Pb exposureclinical phenotypedementia riskdemographicsdisorder preventiondisorder riskeffective interventionenvironmental chemicalenvironmental chemical exposurefollow-uphuman population studyimprovedlead exposuremachine learning methodmodifiable riskmolecular phenotypemulti-ethnicneurotoxicneurotoxicitynovelpopulation basedprecision medicinepreventprospectiverisk predictionrisk prediction modelrisk stratificationsymposiumtau expressiontoxicant
项目摘要
PROJECT SUMMARY
The rising prevalence of Alzheimer's disease and related dementias (ADRD) is a major public health and
clinical challenge in the United States. Identification of ADRD causes to inform prevention and policy is the
most efficient way to address these challenges. Most research to date has focused on identifying genetic
causes of ADRD, however, recent population-scale studies have shown that environmental exposures, such as
lead and cadmium, also contribute to ADRD risk and etiology. Initial findings on environmental factors linked to
ADRD risk is promising, but human evidence is limited. A wide range of environmental exposures (exposome)
have never been evaluated systematically in relation to incident ADRD. While there is a growing demand to
predict future risk for ADRS more precisely, the role of exposomic data in improving ADRD risk prediction has
never been evaluated. To address these gaps, we propose a prospective cohort study by capitalizing on
existing large-scale, United States nationally representative, multi-ethnic population-based data. The National
Health and Nutrition Examination Survey (NHANES, from 1998-2010, n>15,000) has a variety of
environmental chemical exposure measurements, behavioral risk factors, and clinical phenotypes, and when
linked to Medicare data, provides up to 25 years of incident ADRD. We aim to (1) conduct a biologic
hypothesis-based approach to test the associations of chronic exposure to lead and cadmium with incident
ADRD; (2) conduct a data-driven environment-wide association study to systematically evaluate a wide-range
of environmental toxicants with incident ADRD; and (3) develop and validate an exposome-based risk
prediction model for ADRD using machine learning methods. The proposed study will advance scientific
understanding on how modifiable and currently ubiquitous environmental neurotoxicants can lead to the
development of ADRD. This study assesses the exposome to improve prediction of future disease risk and
define vulnerable populations more precisely. This research will highlight individual-level and population-level
interventions (i.e. precision health) to effectively prevent or reduce the risk of ADRD in the US population.
项目摘要
阿尔茨海默病和相关痴呆(ADRD)的患病率上升是一个主要的公共卫生问题,
美国的临床挑战。确定ADRD原因以告知预防和政策是
最有效的方法来应对这些挑战。到目前为止,大多数研究都集中在识别遗传
然而,最近的人口规模研究表明,环境暴露,如
铅和镉也是ADRD风险和病因。与环境因素有关的初步调查结果
ADRD风险是有希望的,但人类证据有限。广泛的环境暴露(麻烦)
从未对ADRD事件进行过系统评价。虽然有越来越多的需求,
为了更准确地预测ADRS的未来风险,药物组学数据在改善ADRD风险预测中的作用已经
从未被评估过。为了解决这些差距,我们提出了一项前瞻性队列研究,
现有的大规模,美国全国代表性,多种族人口为基础的数据。国家
健康和营养检查调查(NHANES,1998-2010年,n> 15,000)有各种各样的
环境化学品暴露测量、行为风险因素和临床表型,以及
与医疗保险数据相关联,提供长达25年的ADRD事件。我们的目标是(1)进行生物学
基于假设的方法来检验慢性铅和镉暴露与事件的关系
ADRD;(2)进行数据驱动的全环境关联研究,以系统地评估广泛的
环境毒物与事件ADRD;和(3)开发和验证基于麻烦的风险
使用机器学习方法建立ADRD的预测模型。这项研究将推动科学
了解可改变的和目前普遍存在的环境神经毒物如何导致
ADRD的发展。这项研究评估了该基因组,以改善对未来疾病风险的预测,
更准确地界定弱势群体。这项研究将突出个人水平和群体水平
干预措施(即精准健康),以有效预防或降低美国人群中ADRD的风险。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Kelly Marie Bakulski其他文献
Kelly Marie Bakulski的其他文献
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{{ truncateString('Kelly Marie Bakulski', 18)}}的其他基金
Risk of Alzheimer's Disease and Related Dementias from Perinatal Lead Exposure: Brain Region and Cell Type Effects
围产期铅暴露导致阿尔茨海默病和相关痴呆的风险:大脑区域和细胞类型的影响
- 批准号:
10369814 - 财政年份:2022
- 资助金额:
$ 66.65万 - 项目类别:
Risk of Alzheimer's Disease and Related Dementias from Perinatal Lead Exposure: Brain Region and Cell Type Effects
围产期铅暴露导致阿尔茨海默病和相关痴呆的风险:大脑区域和细胞类型的影响
- 批准号:
10570921 - 财政年份:2022
- 资助金额:
$ 66.65万 - 项目类别:
The Study of the Environment and Alzheimer's disease and related Dementias (SEAD)
环境与阿尔茨海默病和相关痴呆症的研究 (SEAD)
- 批准号:
10579862 - 财政年份:2021
- 资助金额:
$ 66.65万 - 项目类别:
DNA Methylation,Genetics, and Modifiable Risk Factors of Dementia in a Nationally Representative, Multi-Ethnic Cohort
具有全国代表性的多种族队列中痴呆症的 DNA 甲基化、遗传学和可改变的危险因素
- 批准号:
10163117 - 财政年份:2020
- 资助金额:
$ 66.65万 - 项目类别:
DNA Methylation,Genetics, and Modifiable Risk Factors of Dementia in a Nationally Representative, Multi-Ethnic Cohort
具有全国代表性的多种族队列中痴呆症的 DNA 甲基化、遗传学和可改变的危险因素
- 批准号:
10374124 - 财政年份:2020
- 资助金额:
$ 66.65万 - 项目类别:
DNA Methylation,Genetics, and Modifiable Risk Factors of Dementia in a Nationally Representative, Multi-Ethnic Cohort
具有全国代表性的多种族队列中痴呆症的 DNA 甲基化、遗传学和可改变的危险因素
- 批准号:
10371393 - 财政年份:2020
- 资助金额:
$ 66.65万 - 项目类别:
DNA Methylation,Genetics, and Modifiable Risk Factors of Dementia in a Nationally Representative, Multi-Ethnic Cohort
具有全国代表性的多种族队列中痴呆症的 DNA 甲基化、遗传学和可改变的危险因素
- 批准号:
10605184 - 财政年份:2020
- 资助金额:
$ 66.65万 - 项目类别:
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