Greater Intermountain Node

项目摘要 目前阿片类药物危机的范围要求卫生系统对成瘾做出广泛的反应， 超越了专门的成瘾护理系统。迫切需要扩大研究基础设施 开发、测试和实施新的临床干预措施和循证阿片使用障碍(OUD) 在不同的临床环境中进行治疗。我们建议犹他大学(UofU)的大山间节点 (GIN)通过开发和测试来扩展现有的NIH NIDA临床试验网络(CTN)基础设施 创新的OUD干预措施，扩大了CTN研究的环境，并带来了新的研究敏锐性 CTN。杜松子酒带来了OUD研究的三个领域的专业知识：1)非成瘾医疗保健环境，2) 大型保健系统，以及3)实施科学。金氏非成瘾专科护理领域 设置研究将使CTN能够通过以下方式继续并进一步建立用于OUD研究的这些设置 利用GIN教职员工进行持续研究的环境，例如，在初级保健方面， 产科和社区药房。GIN的保健系统研究领域将使CTN 访问犹他州全面的、相关联的健康/社会服务系统数据库和退伍军人健康 管理集成数据系统，除了带来丰富的数据科学和 信息学。GIN的实施科学领域将使CTN能够促进和支持实施 研究建议、专业知识和环境，重点是研究/改进实施 OUD的药物治疗、OUD识别和农村临床治疗，以及改进 提供者对OUD患者的知识、态度和临床行为。推进这些方面的工作 目标领域将使杜松子酒能够成功实现以下具体目标(SA)：SA1：增强 CTN在初级保健和非成瘾护理环境中进行研究的能力(例如初级保健、住院病人、 药房)；SA2：利用“大数据”增强CTN在综合护理系统内进行研究的能力 资源(犹他州人口级数据库，退伍军人事务部)；SA3：加强CTN执行工作的能力 科学研究迅速有效地将循证成瘾护理整合和传播到 不同的非成瘾和健康系统目标。杜松子酒的跨学科领导团队已经证明 在成瘾调查奖学金方面的记录。我们将利用强有力的机构承诺和 基础设施，专注于与成瘾相关的研究的机构中心，以及具有强大 与临床医生、教育工作者和社区利益相关者建立地区和国家联系。

PROJECT ABSTRACT The scope of the current opioid crisis necessitates a broad-based health system response to addiction that extends beyond the specialty addiction care system. There is a critical need to expand research infrastructure to develop, test, and implement new clinical interventions and evidence-based opioid use disorder (OUD) treatment into diverse clinical settings. We propose the University of Utah’s (UofU) Greater Intermountain Node (GIN) to expand the existing NIH NIDA Clinical Trial Network’s (CTN) infrastructure by developing and testing innovative OUD interventions, expanding the settings for CTN research, and bringing new research acumen to the CTN. The GIN brings expertise in three spheres of OUD research: 1) non-addiction health care settings, 2) large health systems of care, and 3) implementation science. GIN’s sphere of non-addiction specialty care settings research will enable the CTN to continue and further establish these settings for OUD research by leveraging environments where GIN faculty are conducting ongoing research, for example, in primary care, obstetrical, and community pharmacies. GIN’s sphere of health systems of care research will enable the CTN access to Utah’s comprehensive, linked health/social service system databases and the Veterans Health Administration integrated data system in addition to bringing extensive experience in data science and informatics. GIN’s sphere of implementation science will allow CTN to promote and support implementation research proposals, expertise, and environments with a focus on studying/improving implementation of medication treatment for OUD, OUD identification and treatment in rural clinical settings, and improving provider knowledge, attitudes, and clinical behaviors toward patients with OUD. Advancing the work of these targeted spheres will enable the GIN to successfully achieve the following Specific Aims (SA): SA1: Enhance CTN’s ability to conduct research in primary care and non-addiction care settings (e.g. primary care, inpatient, pharmacy); SA2: Enhance CTN’s ability to conduct research within integrated systems of care with “big data” resources (Utah population-level databases, VA); and SA3: Enhance CTN’s ability to conduct implementation science research to rapidly and effectively integrate and disseminate evidence-based addiction care into diverse non-addiction and health system targets. The GIN’s interdisciplinary leadership team has a proven track record in addiction investigative scholarship. We will leverage a robust institutional commitment and infrastructure, institutional centers focused on addiction-related research, and training programs with strong regional and national connections to clinicians, educators, and community stakeholders.