Greater Intermountain Node

项目摘要 当前阿片类药物危机的范围需要对成瘾问题采取广泛的卫生系统应对措施， 超出了专业成瘾护理系统的范围。迫切需要扩大研究基础设施 开发、测试和实施新的临床干预措施和基于证据的阿片类药物使用障碍 (OUD) 治疗进入不同的临床环境。我们提议犹他大学 (UofU) 大山间节点 (GIN) 通过开发和测试来扩展现有的 NIH NIDA 临床试验网络 (CTN) 基础设施 创新的 OUD 干预措施，扩大 CTN 研究的环境，并为 CTN。 GIN 带来了 OUD 研究三个领域的专业知识：1) 非成瘾医疗保健环境，2) 大型卫生保健系统，以及 3) 实施科学。 GIN 的非成瘾专业护理领域 设置研究将使 CTN 能够继续并进一步为 OUD 研究建立这些设置 利用 GIN 教师正在进行的研究环境，例如在初级保健领域， 产科和社区药房。 GIN 的卫生保健系统研究领域将使 CTN 成为可能 访问犹他州全面的、相互关联的健康/社会服务系统数据库和退伍军人健康 管理集成数据系统除了带来数据科学和数据方面的丰富经验外 信息学。 GIN 的实施科学领域将使 CTN 能够促进和支持实施 研究提案、专业知识和环境，重点是研究/改进实施 OUD 的药物治疗、农村临床环境中 OUD 的识别和治疗，以及改善 提供者对 OUD 患者的知识、态度和临床行为。推进这些工作 目标领域将使 GIN 能够成功实现以下具体目标 (SA)： SA1：增强 CTN 有能力在初级保健和非成瘾护理环境（例如初级保健、住院、 药房）； SA2：增强CTN利用“大数据”在综合护理系统中进行研究的能力 资源（犹他州人口级数据库，VA）； SA3：增强CTN的实施能力 科学研究，以快速有效地将基于证据的成瘾治疗整合并传播到 多样化的防成瘾和卫生系统目标。 GIN 的跨学科领导团队拥有久经考验的能力 成瘾调查奖学金的记录。我们将利用强有力的机构承诺和 基础设施、专注于成瘾相关研究的机构中心以及具有强大实力的培训计划 与临床医生、教育工作者和社区利益相关者的区域和国家联系。

PROJECT ABSTRACT The scope of the current opioid crisis necessitates a broad-based health system response to addiction that extends beyond the specialty addiction care system. There is a critical need to expand research infrastructure to develop, test, and implement new clinical interventions and evidence-based opioid use disorder (OUD) treatment into diverse clinical settings. We propose the University of Utah’s (UofU) Greater Intermountain Node (GIN) to expand the existing NIH NIDA Clinical Trial Network’s (CTN) infrastructure by developing and testing innovative OUD interventions, expanding the settings for CTN research, and bringing new research acumen to the CTN. The GIN brings expertise in three spheres of OUD research: 1) non-addiction health care settings, 2) large health systems of care, and 3) implementation science. GIN’s sphere of non-addiction specialty care settings research will enable the CTN to continue and further establish these settings for OUD research by leveraging environments where GIN faculty are conducting ongoing research, for example, in primary care, obstetrical, and community pharmacies. GIN’s sphere of health systems of care research will enable the CTN access to Utah’s comprehensive, linked health/social service system databases and the Veterans Health Administration integrated data system in addition to bringing extensive experience in data science and informatics. GIN’s sphere of implementation science will allow CTN to promote and support implementation research proposals, expertise, and environments with a focus on studying/improving implementation of medication treatment for OUD, OUD identification and treatment in rural clinical settings, and improving provider knowledge, attitudes, and clinical behaviors toward patients with OUD. Advancing the work of these targeted spheres will enable the GIN to successfully achieve the following Specific Aims (SA): SA1: Enhance CTN’s ability to conduct research in primary care and non-addiction care settings (e.g. primary care, inpatient, pharmacy); SA2: Enhance CTN’s ability to conduct research within integrated systems of care with “big data” resources (Utah population-level databases, VA); and SA3: Enhance CTN’s ability to conduct implementation science research to rapidly and effectively integrate and disseminate evidence-based addiction care into diverse non-addiction and health system targets. The GIN’s interdisciplinary leadership team has a proven track record in addiction investigative scholarship. We will leverage a robust institutional commitment and infrastructure, institutional centers focused on addiction-related research, and training programs with strong regional and national connections to clinicians, educators, and community stakeholders.