Greater Intermountain Node

项目摘要 目前阿片类药物危机的范围需要一个基础广泛的卫生系统对成瘾作出反应， 超越了专业戒毒治疗系统迫切需要扩大研究基础设施 开发，测试和实施新的临床干预措施和基于证据的阿片类药物使用障碍（OUD） 在不同的临床环境中进行治疗。我们建议犹他州大学（UofU）的大山间节点 (GIN)通过开发和测试现有的NIH NIDA临床试验网络（CTN）基础设施， 创新的OUD干预措施，扩大CTN研究的设置，并带来新的研究敏锐度， CTN。GIN带来了OUD研究三个领域的专业知识：1）非成瘾医疗保健环境，2） 大型医疗保健系统，以及3）实施科学。GIN的非成瘾专业护理领域 环境研究将使CTN能够继续并进一步为OUD研究建立这些环境， 利用GIN教师正在进行研究的环境，例如，在初级保健中， 产科和社区药房。GIN的护理研究卫生系统领域将使CTN 访问犹他州全面的、链接的健康/社会服务系统数据库和退伍军人健康 管理集成数据系统，除了带来丰富的数据科学经验， 信息学. GIN的实施科学领域将使CTN能够促进和支持实施 研究建议，专业知识和环境，重点是研究/改善实施 OUD的药物治疗，农村临床环境中OUD的识别和治疗，以及改善 提供者对OUD患者的知识、态度和临床行为。推动这些机构的工作 有针对性的球体将使全球导航网能够成功地实现以下特定目标（SA）： CTN在初级保健和非成瘾护理环境（如初级保健，住院， SA 2：增强CTN在综合护理系统中利用“大数据”进行研究的能力 资源（犹他州人口级数据库，弗吉尼亚州）;和SA 3：提高CTN的能力，进行实施 科学研究，以迅速有效地整合和传播基于证据的成瘾护理， 不同的非成瘾和卫生系统目标。GIN的跨学科领导团队拥有经过验证的 在成瘾调查奖学金方面的成绩我们将利用强有力的机构承诺， 基础设施，专注于成瘾相关研究的机构中心，以及具有强大 与临床医生、教育工作者和社区利益相关者的区域和国家联系。

PROJECT ABSTRACT The scope of the current opioid crisis necessitates a broad-based health system response to addiction that extends beyond the specialty addiction care system. There is a critical need to expand research infrastructure to develop, test, and implement new clinical interventions and evidence-based opioid use disorder (OUD) treatment into diverse clinical settings. We propose the University of Utah’s (UofU) Greater Intermountain Node (GIN) to expand the existing NIH NIDA Clinical Trial Network’s (CTN) infrastructure by developing and testing innovative OUD interventions, expanding the settings for CTN research, and bringing new research acumen to the CTN. The GIN brings expertise in three spheres of OUD research: 1) non-addiction health care settings, 2) large health systems of care, and 3) implementation science. GIN’s sphere of non-addiction specialty care settings research will enable the CTN to continue and further establish these settings for OUD research by leveraging environments where GIN faculty are conducting ongoing research, for example, in primary care, obstetrical, and community pharmacies. GIN’s sphere of health systems of care research will enable the CTN access to Utah’s comprehensive, linked health/social service system databases and the Veterans Health Administration integrated data system in addition to bringing extensive experience in data science and informatics. GIN’s sphere of implementation science will allow CTN to promote and support implementation research proposals, expertise, and environments with a focus on studying/improving implementation of medication treatment for OUD, OUD identification and treatment in rural clinical settings, and improving provider knowledge, attitudes, and clinical behaviors toward patients with OUD. Advancing the work of these targeted spheres will enable the GIN to successfully achieve the following Specific Aims (SA): SA1: Enhance CTN’s ability to conduct research in primary care and non-addiction care settings (e.g. primary care, inpatient, pharmacy); SA2: Enhance CTN’s ability to conduct research within integrated systems of care with “big data” resources (Utah population-level databases, VA); and SA3: Enhance CTN’s ability to conduct implementation science research to rapidly and effectively integrate and disseminate evidence-based addiction care into diverse non-addiction and health system targets. The GIN’s interdisciplinary leadership team has a proven track record in addiction investigative scholarship. We will leverage a robust institutional commitment and infrastructure, institutional centers focused on addiction-related research, and training programs with strong regional and national connections to clinicians, educators, and community stakeholders.