Essential characterization of the Randall's plaque-overgrowth interface

兰德尔斑块过度生长界面的基本特征

• 批准号: 10373023
• 负责人: JAMES C WILLIAMS
• 金额: $ 23.78万
• 依托单位: INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-05-01 至 2024-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10373023
• 关键词: 3-Dimensional; American; Automobile Driving; Benign; Calcium Oxalate; Characteristics; Collection; Data; Deposition; Disease; Dissection; Duct (organ) structure; Event; Female; Fluorescence; Foundations; Future; Goals; Growth; Health Care Costs; Histologic; In Situ; Kidney; Kidney Calculi; Kidney Papilla; Label; Lasers; Learning; Light; Maps; Mass Spectrum Analysis; Methods; Microdissection; Microscopy; Minerals; Pathogenesis; Pathology; Pathway interactions; Patients; Pattern; Persons; Pharmacologic Substance; Phase; Proteins; Proteome; Set protein; Site; Structure; Sum; Symptoms; Testing; Time; Urine; Work; base; calcification; common treatment; effective therapy; infrared microscopy; interstitial; kidney interstitial tissue; male; metabolic profile; microCT; mineralization; multiphoton imaging; prevent; sex; therapy development

Kidney stones afflict about 1 in 11 Americans and the most common stones are composed of calcium oxalate (CaOx), but no therapies exist to treat CaOx kidney stone formation at its earliest stages. Recent evidence strongly suggests that patients who retain stones in their kidneys during the earliest phase of stone growth solely via the mechanism of Randall’s (interstitial) plaque (RP) have a fundamentally different pathology of early stone growth than do those patients who retain stones in the kidney via other mechanisms. In spite of how common this pathway seems to be, the mechanism by which early stone growth proceeds on RP—and how this form of early stone growth may be different from other mechanisms—is not understood well enough to direct therapies toward blocking the growth of early stones in this most-common of CaOx patients. The overall objective for the present proposal is to map the mineral and protein transitions as CaOx stones initiate on Randall’s plaque. The work proposed here is foundational for learning how to block the genesis of these stones, and thus to provide treatment to prevent stones from forming on Randall’s plaques.

肾结石困扰着大约11个美国人，最常见的石头由草酸钙（Caox）组成，但没有治疗Caox肾结石形成的疗法。最近的证据强烈表明，在最早的石材生长阶段保留石头的患者仅通过Randall（间质）斑块（RP）的机制（RP）与早期石材生长的病理根本不同，而那些通过其他机制保留肾脏中的石头的患者的病理根本不同。尽管这种途径似乎是多么常见，但早期石材生长在RP上进行的机制以及这种早期石材生长的形式与其他机制的不同 - 不够理解，无法将疗法直接用于阻止这种最常见的CAOX患者中早期石材的生长。发起兰德尔的牌匾。这里提出的工作是学习如何阻止这些石头起源的基础，因此提供治疗以防止石头在兰德尔的斑块上形成。