SkyScan 1172 High-resolution desk-top micro-CT system

描述(由申请人提供)：这项提案是为了购买SkyScan 1172微型计算机断层扫描(CT)系统，该系统将为NIH资助的10个研究小组提供服务。我们目前的微型CT系统已经在最大限度地工作了五年，但其图像分辨率质量不足以应用于软组织或任何小于25？m的结构。我们校园对微型CT的需求持续增长，拟议的系统将允许在低对比度样本中也能很好地分辨率精细结构，以便适应或开发微型CT的新应用。SkyScan 1172可以以非常高的分辨率对标本进行成像--体素尺寸小于1？m，低对比度分辨率为5？m。一次典型的扫描只需要大约一个小时，该系统配备了一个由集群PC组成的重建工作站和特殊软件，允许快速计算图像切片，以便用户可以在下一个样本进行扫描时重建扫描。这将提供所需的高吞吐量，以满足我们的研究界对微型CT的需求。该设备的应用包括：1)阐明肾结石的精细结构，用于研究冲击波碎石的机制和结石形成的研究。2)手术中取自结石患者的肾活检组织的细微结构可视化，显示了肾结石形成的最早阶段。3)早期龋病的检测。4)慢性肾脏病血管钙化的标测和定量。5)对肢体和器官血管床进行定量和成像，以研究周围血管疾病和心肌梗死。6)骨质疏松症、骨结构的遗传基础、溶骨性癌、药物对骨的影响、微裂纹的发展、骨伤口愈合和人工支架中骨再生的研究中的骨结构的成像和定量。收购SkyScan 1172对于这些和未来需要这种最先进技术的项目的持续进展至关重要。 关联性。这项建议是为了购买一个新的微型CT(“CAT”扫描仪)系统，该系统将用于研究几个实验室的生物标本。这项技术将可能在骨病(如骨质疏松症)、血管疾病(包括慢性肾脏疾病中血管中的钙沉积)、牙齿腐烂和肾结石疾病等领域做出新发现。

DESCRIPTION (provided by applicant): This proposal is for the purchase of a SkyScan 1172 micro computed tomography (CT) system, which will serve ten NIH-funded research groups. Our present micro CT system has been working at maximum capacity for five years, but its quality of image resolution is not adequate for applications to soft tissue or to any structures smaller than about 25 ¿m. The demand for micro CT on our campus continues to grow, and the proposed system will allow excellent resolution of fine structure even in low contrast samples, so that new applications for micro CT can be accommodated or developed. The SkyScan 1172 can image specimens with very high resolution-less than 1 ¿m voxel size and low-contrast resolution of 5 ¿m. A typical scan takes only about one hour, and the system comes with a reconstruction workstation of clustered PC's and special software to allow rapid calculation of image slices, so that a user can reconstruct a scan while the next specimen is scanning. This will provide the high throughput required to service the needs of our research community for micro CT. Applications for the proposed facility include: 1) Elucidation of the fine structure of kidney stones, for studies of the mechanisms of stone breakage by shock wave lithotripsy and study of stone formation. 2) Visualization of fine structure of kidney biopsies taken from stone patients during surgery, showing the earliest stages of the formation of kidney stones. 3) Detection of the earliest stages of dental caries. 4) Mapping and quantitation of vascular calcification in chronic renal disease. 5) Quantitation and imaging of vascular beds in limbs and organs injected with contrast fill, to study peripheral vascular disease and myocardial infarction. 6) Imaging and quantitation of bone structure in studies of osteoporosis, of the genetic basis of bone architecture, of osteolytic cancer, drug effects on bone, development of microcracks, wound healing in bone, and of bone regrowth in artificial scaffolds. The acquisition of the SkyScan 1172 is essential for continued progress on these and future projects requiring this state-of-the-art technology. Relevance. This proposal is for purchase of a new micro CT ("cat" scanner) system, which will be used to study biological specimens from several laboratories. This technology will make possible new discoveries in the areas of bone disease (such as osteoporosis), blood vessel disease (including the deposition of calcium in vessels in chronic kidney disease), tooth decay, and kidney stone disease.