SkyScan 1176 Micro CT System

描述(申请人提供)：此方案是为了购买SkyScan 1176活体Micro CT系统，这将为我们的核心用户增加新的功能。参与这一合作的17个实验室参与了一系列由NIH资助的项目，我们有在这个共享设施中成功合作的历史。为了方便这些共享设备的管理，我们与印第安纳生物医学成像科学研究所合作，后者在校园范围内提供生物医学成像方面的帮助。对Skyscan1176系统的要求有三个理由：增加活体扫描能力，允许大样本体外扫描，以及减少现有CT系统的容量。目前的微型CT系统(2007年获得的SkyScan 1172)对矿化组织提供了出色的成像，但只能用于体外标本。SkyScan 1176将使研究人员能够利用实验方案来监控他们的实验动物体内组织随时间的变化，从而在使用更少动物的同时提供纵向数据。SkyScan 1176还将允许扫描更大的完整标本(如猪心和人肾)，而目前的系统无法容纳这些标本。就容量而言，目前的系统无法处理NIH资助的该校园项目所需的大量微型CT成像。SkyScan 1176可以用来扫描许多现在旧的1172系统上正在扫描的标本，参数相同，从而缓解了现有设施的压力。SkyScan 1176系统是对现有系统的补充。这意味着，目前的用户只需进行最低限度的再培训。此外，对于大多数用户来说，这两个系统可以互换使用，从而可以减轻现有系统目前的全部负荷，从而使每个实验室都能及时获得其标本的数据。

DESCRIPTION (provided by applicant): This proposal is for the purchase of a SkyScan 1176 In-vivo Micro CT system, which will add new capabilities to our core of users. The seventeen laboratories collaborating in this venture are involved in a wide range of NIH-funded ventures, and we have a history of working together successfully in this shared facility. To facilitate administration of this shared equipment we have partnered with the Indiana Institute for Biomedical Imaging Sciences, who provide campus-wide assistance with biomedical imaging. The request for a Skyscan 1176 system has a three-fold rationale: adding in vivo scanning capability, allowing large specimen ex vivo scanning, and reducing capacity on the present CT system. The present micro CT system (a SkyScan 1172, obtained in 2007) provides excellent imaging of mineralized tissues, but can be used only for ex vivo specimens. The SkyScan 1176 will enable researchers to utilize experimental protocols that can monitor the changes in tissue over time in their experimental animals, thereby provided longitudinal data while simultaneously using fewer animals. The SkyScan 1176 will also allow the scanning of larger intact specimens (like pig hearts and human kidneys) which cannot be accommodated on the present system. With regard to capacity, the present system cannot handle the high volume of micro CT imaging demanded by NIH-funded projects on this campus. The SkyScan 1176 can be used to scan many of the specimens now being scanned on the old 1172 system, with identical parameters, and so relieve pressure on the present facility. The SkyScan 1176 system is complementary to the presently existing system. This means that minimal retraining will be required for present users. Moreover, for most users the two systems can be used interchangeably, so that the present full load on the existing system can be relieved, thus allowing every laboratory to obtain data on its specimens in a timely manner.