Speech Profiles and Cue Responsiveness After Left Hemisphere Stroke

左半球中风后的言语轮廓和提示反应

• 批准号: 10376843
• 负责人: KATARINA L HALEY
• 金额: $ 48.77万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-04-01 至 2025-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10376843
• 关键词: Acoustics; Affect; Aphasia; Apraxias; Articulation; Attention; Auditory; Behavior Therapy; Behavioral; Categories; Characteristics; Clinical; Clinical Management; Clinical Practice Guideline; Clinical Research; Confusion; Consequentialism; Cues; Custom; Data; Diagnosis; Diagnostic; Diagnostic Procedure; Differential Diagnosis; Dimensions; Disease; Documentation; Dysarthria; Evidence based practice; Foundations; Goals; Guidelines; Impairment; Individual; Intervention; Intervention Studies; Laboratories; Left; Life; Link; Literature; Measurement; Methodology; Methods; Motor; Motor Neurons; Nature; Outcome; Performance; Persons; Phase; Practice Guidelines; Procedures; Process; Production; Prognosis; Psychometrics; Quality of life; Reference Standards; Research; Research Personnel; Sample Size; Sampling; Severities; Speech; Speech Disorders; Standardization; Stroke; Structure; Syndrome; System; Taxonomy; Testing; Time; Uncertainty; United States; Variant; base; clinically relevant; diagnosis standard; diagnostic criteria; feasibility testing; impression; improved; individualized medicine; personalized intervention; phonology; post stroke; programs; sound; tool; treatment planning

ABSTRACT Speech production difficulties affect most of the approximately 2 million people with aphasia in the United States. Behavioral manifestations of speech impairment are heterogeneous and imperfectly categorized with current systems for differential diagnosis. Though customized treatment based on different speech profiles is widely believed to improve communicative abilities and quality of life, evidence-based practice is limited due to a poorly defined diagnostic process and uncertainty about which speech features distinguish among the core disorder categories (apraxia of speech, aphasia with phonemic paraphasia, unilateral upper motor neuron dysarthria), as they are defined behaviorally. In this project, we introduce a system for quantitative documentation and analysis of clinically relevant speech characteristics. The purpose of Aim 1 is to develop a new assessment for documenting speech profiles and estimating their severity. We define boundaries between normal and impaired speech production across key dimensions and metrics and identify a psychometrically sound and clinically feasible test for estimating severity and characterizing multidimensional speech profiles. In Aim 2, we develop a quantitative signature for speech profiles through empirically focused analyses. By replacing existing diagnostic checklists with empirically validated profiles, we expect project outcomes will resolve diagnostic confusion that has persisted for decades. The link between diagnosis and intervention is developed in Aim 3, in order to establish a foundation for precision intervention research. The project is expected to generate sound assessment and diagnostic procedures and remove fundamental barriers to scientific discovery concerning speech production difficulties after stroke.

摘要 语言产生困难影响了大约200万失语症患者中的大多数， 美国的言语障碍的行为表现是异质的， 不完全与目前的系统进行分类的鉴别诊断。虽然定制 基于不同语音特征的治疗被广泛认为可以改善交际能力。 能力和生活质量，循证实践是有限的，由于定义不清的诊断 过程和不确定性的语音特征区分之间的核心障碍 类别（言语失用症，失语伴音位错语，单侧上运动 神经元构音障碍），因为它们是行为上定义的。在这个项目中，我们介绍了一个系统， 临床相关语音特征的定量记录和分析。的 目标1的目的是开发一种新的评估方法，用于记录语音特征， 估计其严重性。我们定义了正常言语和受损言语的界限 生产跨越关键尺寸和指标，并确定一个心理测量的声音， 用于估计严重性和表征多维语音的临床可行的测试 数据区.在目标2中，我们通过经验开发了语音轮廓的定量签名， 集中分析。通过用经验验证的配置文件替换现有的诊断检查表， 我们预计项目成果将解决持续数十年的诊断混乱。 目标3中建立了诊断和干预之间的联系，以建立 精准干预研究基金会。该项目预计将产生声音 评估和诊断程序，消除科学发现的根本障碍 关于中风后的言语产生困难。