A preconception cohort study of air pollution, fertility, and miscarriage
空气污染、生育力和流产的孕前队列研究
基本信息
- 批准号:10376355
- 负责人:
- 金额:$ 31.21万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2018
- 资助国家:美国
- 起止时间:2018-07-01 至 2023-12-31
- 项目状态:已结题
- 来源:
- 关键词:AddressAffectAirAir PollutantsAir PollutionCanadaCardiovascular systemChemicalsChildClinicalCohort StudiesConceptionsConfounding Factors (Epidemiology)CouplesDataData CollectionDenmarkEnrollmentEnvironmental HazardsEpidemiologyEtiologyExposure toFertilityFollow-Up StudiesFoundationsFundingFutureGeographic Information SystemsGeographyGrantGravidHealthHumanIndividualInfertilityInterdisciplinary StudyInternetJointsLeadLinkLiteratureLow Birth Weight InfantMeasuresMedicalModelingMothersNational Institute of Child Health and Human DevelopmentNeighborhoodsNitrogen DioxideNorth AmericaOnline SystemsOutcomeOzoneParticipantParticulate MatterPollutionPre-EclampsiaPredispositionPregnancyPregnancy lossPregnant WomenPremature BirthPrimary PreventionProbabilityProspective StudiesProspective cohort studyProxyPublic HealthQuestionnairesReproductive HealthResearch DesignRetrospective StudiesRiskRisk FactorsSample SizeSpontaneous abortionStatistical MethodsTechniquesTimeUnited StatesUniversitiesUnsafe SexWashingtonWomanadverse pregnancy outcomeagedbasechild bearingcohortcostcost effectivecost estimatedensityearly pregnancyethnic diversityfine particlesfollow-uphealth goalshigh riskimprovedinfertility treatmentinsightinterestmodifiable risknovelparticlepollutantpregnantprospectivepsychologicrecruitreproductiveresidencesoftware systemsspatiotemporalstillbirthsubfertilitysuccesstime-to-pregnancytraffic-related air pollution
项目摘要
ABSTRACT
Infertility and spontaneous abortion (SAB) are significant public health problems, each affecting up to 20% of
reproductive-aged couples in the United States. As couples increasingly postpone childbearing to the later
reproductive years, many seek infertility treatment, which has relatively low success rates, costs an estimated
$5 billion per year, and is associated with adverse pregnancy outcomes. Therefore, identifying modifiable risk
factors for subfertility and SAB is an important public health goal. The potential effects of air pollution on risk of
subfertility and SAB are understudied. The few existing human studies have major limitations including
retrospective study design, small study size, suboptimal assessment of exposure and outcome, inadequate
control for potential confounding variables, and limited generalizability. The proposed study will assess the
relation of several air pollutants to risk of subfertility and SAB in two interrelated preconception prospective cohort
studies in North America and Denmark. Using web-based recruitment, data collection, and follow-up, we have
enrolled over 16,500 women attempting pregnancy, collectively comprising the largest preconception cohort
study ever conducted on factors related to fertility and SAB. We have collected prospective data on time-to-
pregnancy, SAB, potential confounders in both partners, and residential addresses at baseline and on bi-monthly
follow-up questionnaires for all participants, providing the foundation for accurate time-varying assessment of
exposure to air pollution throughout the preconception and early pregnancy periods. Our specific aims are to
develop spatio-temporal models of ambient PM2.5, NO2, and O3 for the etiologic time periods of interest, construct
measures of traffic and roadway density around each residence using geographic information system software,
and assign appropriate time-varying estimates of exposure. Among 18,500 women, we will examine the
association between individual measures of air pollution (PM2.5, NO2, O3 and measures of traffic density) and
fecundability, the cycle-specific probability of conception. We will evaluate the same measures of air pollution
with risk of SAB. We will also utilize state-of-the-art statistical methods, including predictive k-means clustering,
to examine the effects of pollutant mixtures, with an emphasis on speciation of PM components. Strengths of
this application include its large study size, preconception enrollment of a geographically and ethnically diverse
cohort of pregnancy planners, assessment of repeated measures of exposure during the preconception and
early pregnancy periods, excellent control for individual-level and neighborhood-level confounding via collection
of data on a wide range of covariates, and the use of multi-pollutant modeling techniques. The present application
is cost-effective in leveraging already-established cohort studies funded by the NICHD. The proposed study
addresses novel and important reproductive health outcomes that have had only limited study in relation to air
pollution. Study results are likely to inform primary prevention of infertility and SAB, and add to evidence used
by regulators to improve air quality.
摘要
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
ELIZABETH E HATCH其他文献
ELIZABETH E HATCH的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('ELIZABETH E HATCH', 18)}}的其他基金
A preconception cohort study of environmental chemicals, fertility, and miscarriage
环境化学物质、生育力和流产的孕前队列研究
- 批准号:
10057270 - 财政年份:2019
- 资助金额:
$ 31.21万 - 项目类别:
A preconception cohort study of environmental chemicals, fertility, and miscarriage
环境化学物质、生育力和流产的孕前队列研究
- 批准号:
10294233 - 财政年份:2019
- 资助金额:
$ 31.21万 - 项目类别:
A preconception cohort study of air pollution, fertility, and miscarriage
空气污染、生育力和流产的孕前队列研究
- 批准号:
9892011 - 财政年份:2018
- 资助金额:
$ 31.21万 - 项目类别:
An internet-based preconception cohort study in North America and Denmark
北美和丹麦基于互联网的孕前队列研究
- 批准号:
9982084 - 财政年份:2016
- 资助金额:
$ 31.21万 - 项目类别:
An internet-based preconception cohort study in North America and Denmark
北美和丹麦基于互联网的孕前队列研究
- 批准号:
10434313 - 财政年份:2016
- 资助金额:
$ 31.21万 - 项目类别:
An internet based prospective study of time to pregnancy
基于互联网的怀孕时间前瞻性研究
- 批准号:
8225330 - 财政年份:2010
- 资助金额:
$ 31.21万 - 项目类别:
An internet based prospective study of time to pregnancy
基于互联网的怀孕时间前瞻性研究
- 批准号:
8434255 - 财政年份:2010
- 资助金额:
$ 31.21万 - 项目类别:
An internet based prospective study of time to pregnancy
基于互联网的怀孕时间前瞻性研究
- 批准号:
7786408 - 财政年份:2010
- 资助金额:
$ 31.21万 - 项目类别:
An internet based prospective study of time to pregnancy
基于互联网的怀孕时间前瞻性研究
- 批准号:
8600705 - 财政年份:2010
- 资助金额:
$ 31.21万 - 项目类别:
An internet based prospective study of time to pregnancy
基于互联网的怀孕时间前瞻性研究
- 批准号:
8013944 - 财政年份:2010
- 资助金额:
$ 31.21万 - 项目类别:
相似海外基金
How Does Particle Material Properties Insoluble and Partially Soluble Affect Sensory Perception Of Fat based Products
不溶性和部分可溶的颗粒材料特性如何影响脂肪基产品的感官知觉
- 批准号:
BB/Z514391/1 - 财政年份:2024
- 资助金额:
$ 31.21万 - 项目类别:
Training Grant
BRC-BIO: Establishing Astrangia poculata as a study system to understand how multi-partner symbiotic interactions affect pathogen response in cnidarians
BRC-BIO:建立 Astrangia poculata 作为研究系统,以了解多伙伴共生相互作用如何影响刺胞动物的病原体反应
- 批准号:
2312555 - 财政年份:2024
- 资助金额:
$ 31.21万 - 项目类别:
Standard Grant
RII Track-4:NSF: From the Ground Up to the Air Above Coastal Dunes: How Groundwater and Evaporation Affect the Mechanism of Wind Erosion
RII Track-4:NSF:从地面到沿海沙丘上方的空气:地下水和蒸发如何影响风蚀机制
- 批准号:
2327346 - 财政年份:2024
- 资助金额:
$ 31.21万 - 项目类别:
Standard Grant
Graduating in Austerity: Do Welfare Cuts Affect the Career Path of University Students?
紧缩毕业:福利削减会影响大学生的职业道路吗?
- 批准号:
ES/Z502595/1 - 财政年份:2024
- 资助金额:
$ 31.21万 - 项目类别:
Fellowship
感性個人差指標 Affect-X の構築とビスポークAIサービスの基盤確立
建立个人敏感度指数 Affect-X 并为定制人工智能服务奠定基础
- 批准号:
23K24936 - 财政年份:2024
- 资助金额:
$ 31.21万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Insecure lives and the policy disconnect: How multiple insecurities affect Levelling Up and what joined-up policy can do to help
不安全的生活和政策脱节:多种不安全因素如何影响升级以及联合政策可以提供哪些帮助
- 批准号:
ES/Z000149/1 - 财政年份:2024
- 资助金额:
$ 31.21万 - 项目类别:
Research Grant
How does metal binding affect the function of proteins targeted by a devastating pathogen of cereal crops?
金属结合如何影响谷类作物毁灭性病原体靶向的蛋白质的功能?
- 批准号:
2901648 - 财政年份:2024
- 资助金额:
$ 31.21万 - 项目类别:
Studentship
Investigating how double-negative T cells affect anti-leukemic and GvHD-inducing activities of conventional T cells
研究双阴性 T 细胞如何影响传统 T 细胞的抗白血病和 GvHD 诱导活性
- 批准号:
488039 - 财政年份:2023
- 资助金额:
$ 31.21万 - 项目类别:
Operating Grants
New Tendencies of French Film Theory: Representation, Body, Affect
法国电影理论新动向:再现、身体、情感
- 批准号:
23K00129 - 财政年份:2023
- 资助金额:
$ 31.21万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
The Protruding Void: Mystical Affect in Samuel Beckett's Prose
突出的虚空:塞缪尔·贝克特散文中的神秘影响
- 批准号:
2883985 - 财政年份:2023
- 资助金额:
$ 31.21万 - 项目类别:
Studentship