Impact of Pediatric Atopic Dermatitis on Neurocognitive Function

小儿特应性皮炎对神经认知功能的影响

• 批准号: 10377528
• 负责人: Joy Wan
• 金额: $ 17.21万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-11-01 至 2026-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10377528
• 关键词: 16 year old; Address; Affect; Anxiety; Area; Atopic Dermatitis; Attention; Attention deficit hyperactivity disorder; Behavior; Birth; Child; Childhood; Chronic; Chronic Disease; Clinic; Cognition; Cognitive; Cognitive deficits; Cross-Sectional Studies; Cutaneous; Data; Data Analyses; Demographic Factors; Dermatologist; Dermatology; Development; Disease; Eczema; Emotions; Enrollment; Environment; Epidemiologist; Epidemiology; Epithelial Cell Aggregation and Separation; Fatigue; Fellowship; Funding; Future; Goals; Growth; Health; Impaired cognition; Impairment; Individual; Intelligence; Intervention; Knowledge; Learning Disabilities; Life; Longitudinal Studies; Longitudinal cohort study; Measurement; Measures; Mediating; Mediation; Mediator of activation protein; Medical; Memory; Mental Depression; Mental Processes; Mentored Patient-Oriented Research Career Development Award; Mentors; Mentorship; Moods; Neurocognition; Neurocognitive; Neuropsychology; Occupational; Outcome; Outcome Measure; Pain; Parents; Participant; Patient Outcomes Assessments; Pediatric Hospitals; Pediatric Research; Pennsylvania; Philadelphia; Positioning Attribute; Problem Solving; Pruritus; Psoriasis; Psychometrics; Quality of life; Questionnaires; Reporting; Research; Research Infrastructure; Research Personnel; Residencies; Resources; Risk; Risk Factors; Services; Severities; Sleep; Sleep disturbances; Social outcome; Socioeconomic Factors; Statistical Methods; Subgroup; Symptoms; Testing; Time; Training; United Kingdom; United States National Institutes of Health; Universities; associated symptom; base; career; career development; clinical examination; clinical practice; cognitive ability; cognitive development; cognitive function; cognitive performance; cognitive testing; cohort; critical developmental period; critical period; economic outcome; emerging adult; executive function; experience; improved; inattention; innovation; instrument; modifiable risk; neuroinflammation; patient oriented; patient oriented research; peer; post-doctoral training; programs; prospective; screening; skin disorder; social; socioeconomics; systemic inflammatory response

PROJECT SUMMARY / ABSTRACT The overall objective of this K23 application is to provide support for the additional training and experience that Dr. Joy Wan, a pediatric dermatologist and epidemiologist, needs to develop an independent, patient-oriented research program in pediatric atopic dermatitis and chronic skin disease. Research: Atopic dermatitis, also known as eczema, affects 20% of children and frequently overlaps with the critical period of cognitive development that occurs in the first two decades of life. Although children with atopic dermatitis are more likely to suffer from learning disabilities, inattention, and poor memory, the impact of atopic dermatitis on cognition has not been rigorously examined. This project will: (1) test the hypothesis that atopic dermatitis, particularly when severe or persistent, is both directly and indirectly associated with cognitive impairments in children, and (2) identify modifiable risk factors that mediate the effects of atopic dermatitis on cognitive function. To achieve these aims, Dr. Wan will use data from a longitudinal study of over 14,000 individuals followed from birth until their 20s and also prospectively enroll a cohort of children with active atopic dermatitis. The results of this project will fill critical gaps in knowledge about the impact of atopic dermatitis on cognition and carry significant implications for clinical practice. Candidate: Dr. Wan earned her MD and MSCE degrees from the University of Pennsylvania, where she also completed dermatology residency followed by pediatric dermatology fellowship at the Children’s Hospital of Philadelphia. Dr. Wan is pursuing post-doctoral training in epidemiology with the goal of becoming an R01-funded investigator and leader in pediatric dermatology research. Environment: Dr. Wan will be primarily mentored by Dr. Joel Gelfand, a dermatologist and epidemiologist with expertise in patient-oriented research in psoriasis and atopic dermatitis, and co-mentored by Dr. Susan Furth, a pediatric nephrologist with expertise in chronic disease epidemiology and patient-oriented pediatric research, Dr. Kristin Linn, a biostatistician with expertise in advanced statistical methods, and Dr. Nina Thomas, a pediatric neuropsychologist with expertise in neurocognition research. She will be further advised by a complementary committee of NIH-funded investigators in pediatric dermatology, neuropsychology, epidemiology, and atopic dermatitis. With its robust research infrastructure and rich resources, Penn provides an ideal environment for Dr. Wan’s research and career growth. Career Development: Dr. Wan’s proposal includes advanced training in longitudinal data analysis and causal inference, neurocognitive development, and patient-reported outcome measures, achieved through a combination of didactic coursework, practical research experience, and focused mentorship. The support of a K23 award will enable Dr. Wan to launch a successful career as an independent investigator dedicated to optimizing the health, social, and life outcomes for children with chronic skin disease.

项目总结/摘要 此K23应用程序的总体目标是为额外的培训和经验提供支持， 博士Joy Wan是一位儿科皮肤病学家和流行病学家，他需要建立一个独立的，以病人为导向的 儿童特应性皮炎和慢性皮肤病的研究计划。研究：特应性皮炎，也 湿疹，影响20%的儿童，并经常与认知能力的关键时期重叠。 在生命的前二十年发生的发展。虽然患有特应性皮炎的儿童 患有学习障碍、注意力不集中和记忆力差，特应性皮炎对认知的影响 还没有经过严格的检验。本项目将：（1）检验特应性皮炎，特别是 严重或持续时，与儿童认知障碍直接或间接相关， (2)识别介导特应性皮炎对认知功能影响的可改变的风险因素。实现 为了实现这些目标，万博士将使用一项纵向研究的数据，该研究对14,000多名个体进行了从出生到 他们的20多岁，并前瞻性地招募了一组患有活动性特应性皮炎的儿童。的结果 该项目将填补关于特应性皮炎对认知影响的知识空白， 对临床实践的影响。候选人：万博士获得了她的MD和MSCE学位，从大学 在宾夕法尼亚州，她还完成了皮肤病学住院医师，随后获得了儿科皮肤病学奖学金 在费城儿童医院温博士目前正在攻读流行病学博士后培训， 目标是成为R 01资助的研究员和儿科皮肤病学研究的领导者。环境：博士 Wan将主要由Joel Gelfand博士指导，他是一位皮肤病学家和流行病学家， 银屑病和特应性皮炎患者为导向的研究，并共同指导博士苏珊Furth，儿科 Kristin博士是一位肾脏病学家，在慢性病流行病学和以患者为导向的儿科研究方面具有专长， Linn博士是一位生物统计学家，擅长先进的统计方法，Nina托马斯博士是一位儿科医生， 在神经认知研究方面有专长的神经心理学家。她将通过一份补充报告进一步了解情况。 NIH资助的儿科皮肤病学、神经心理学、流行病学和特应性过敏症研究者委员会 皮炎凭借其强大的研究基础设施和丰富的资源，宾夕法尼亚大学提供了理想的环境， 博士万的研究和职业成长。职业发展：万博士的建议包括高级培训 在纵向数据分析和因果推理中，神经认知发展和患者报告的结果 措施，通过教学课程，实践研究经验的结合，并集中 导师制K23奖的支持将使温博士能够作为独立人士开始成功的职业生涯。 研究人员致力于优化健康，社会和生活结果的儿童慢性皮肤病。