Impact of Pediatric Atopic Dermatitis on Neurocognitive Function

项目摘要/摘要 此K23应用程序的总体目标是为以下附加培训和体验提供支持 儿科皮肤科医生和流行病学家喜悦万医生需要发展一种独立的、以患者为导向的 儿童特应性皮炎和慢性皮肤病研究计划。研究：特应性皮炎 称为湿疹，影响20%的儿童，经常与认知的关键期重叠 发生在生命的前二十年的发育。尽管患有特应性皮炎的儿童更有可能 患有学习障碍、注意力不集中和记忆力差的特应性皮炎对认知的影响 没有经过严格的审查。该项目将：(1)检验特应性皮炎的假设，特别是 当严重或持续时，与儿童的认知障碍直接或间接相关，以及 (2)确定特应性皮炎对认知功能影响的可改变的危险因素。要实现 为了达到这些目标，万博士将使用一项纵向研究的数据，该研究对14,000多个个体从出生到 他们的20多岁，也前瞻性地登记了一组患有活动性特应性皮炎的儿童。这样做的结果 该项目将填补关于特应性皮炎对认知的影响的知识的关键空白，并具有重大意义 对临床实践的影响。候选人：万博士在加州大学获得医学博士和硕士学位 在宾夕法尼亚州，她还完成了皮肤科住院医师资格，随后又获得了儿科皮肤科研究员资格 在费城儿童医院。万博士现正与 目标是成为R01资助的儿科皮肤病研究的研究员和领导者。环境：Dr。 Wan将主要由Joel Gelfand博士指导，Joel Gelfand博士是一位皮肤科医生和流行病学家，在 以患者为中心的牛皮癣和特应性皮炎研究，由儿科医生Susan Furth共同指导 在慢性病流行病学和以患者为导向的儿科研究方面拥有专业知识的肾病学家克里斯汀博士 林恩是一位在先进统计方法方面拥有专业知识的生物统计学家，尼娜·托马斯博士是一名儿科医生 在神经认知研究方面有专长的神经心理学家。她将得到补充的一份补充意见 美国国立卫生研究院资助的儿科皮肤病、神经心理学、流行病学和特应性研究委员会 皮炎。凭借其强大的研究基础设施和丰富的资源，宾夕法尼亚大学为 万博士的研究和职业发展。职业发展：万博士的建议包括高级培训 在纵向数据分析和因果推断中，神经认知发展和患者报告的结果 措施，通过教学课程、实践研究经验和专注的结合来实现 师徒关系。K23奖项的支持将使万博士作为一名独立人士开始成功的职业生涯 致力于优化慢性皮肤病儿童的健康、社会和生活结果的调查者。

PROJECT SUMMARY / ABSTRACT The overall objective of this K23 application is to provide support for the additional training and experience that Dr. Joy Wan, a pediatric dermatologist and epidemiologist, needs to develop an independent, patient-oriented research program in pediatric atopic dermatitis and chronic skin disease. Research: Atopic dermatitis, also known as eczema, affects 20% of children and frequently overlaps with the critical period of cognitive development that occurs in the first two decades of life. Although children with atopic dermatitis are more likely to suffer from learning disabilities, inattention, and poor memory, the impact of atopic dermatitis on cognition has not been rigorously examined. This project will: (1) test the hypothesis that atopic dermatitis, particularly when severe or persistent, is both directly and indirectly associated with cognitive impairments in children, and (2) identify modifiable risk factors that mediate the effects of atopic dermatitis on cognitive function. To achieve these aims, Dr. Wan will use data from a longitudinal study of over 14,000 individuals followed from birth until their 20s and also prospectively enroll a cohort of children with active atopic dermatitis. The results of this project will fill critical gaps in knowledge about the impact of atopic dermatitis on cognition and carry significant implications for clinical practice. Candidate: Dr. Wan earned her MD and MSCE degrees from the University of Pennsylvania, where she also completed dermatology residency followed by pediatric dermatology fellowship at the Children’s Hospital of Philadelphia. Dr. Wan is pursuing post-doctoral training in epidemiology with the goal of becoming an R01-funded investigator and leader in pediatric dermatology research. Environment: Dr. Wan will be primarily mentored by Dr. Joel Gelfand, a dermatologist and epidemiologist with expertise in patient-oriented research in psoriasis and atopic dermatitis, and co-mentored by Dr. Susan Furth, a pediatric nephrologist with expertise in chronic disease epidemiology and patient-oriented pediatric research, Dr. Kristin Linn, a biostatistician with expertise in advanced statistical methods, and Dr. Nina Thomas, a pediatric neuropsychologist with expertise in neurocognition research. She will be further advised by a complementary committee of NIH-funded investigators in pediatric dermatology, neuropsychology, epidemiology, and atopic dermatitis. With its robust research infrastructure and rich resources, Penn provides an ideal environment for Dr. Wan’s research and career growth. Career Development: Dr. Wan’s proposal includes advanced training in longitudinal data analysis and causal inference, neurocognitive development, and patient-reported outcome measures, achieved through a combination of didactic coursework, practical research experience, and focused mentorship. The support of a K23 award will enable Dr. Wan to launch a successful career as an independent investigator dedicated to optimizing the health, social, and life outcomes for children with chronic skin disease.