Spike Timing Defects and State Representation Impairments in Nonhuman Primates
非人类灵长类动物的尖峰计时缺陷和状态表征损伤
基本信息
- 批准号:10377364
- 负责人:
- 金额:$ 35.54万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-04-01 至 2025-03-31
- 项目状态:未结题
- 来源:
- 关键词:Action PotentialsAnatomyAreaBackBehavior ControlBehavioralBeliefBiologyBrainCellsClinicalCognitionCognitive deficitsCorpus striatum structureDNA Sequence AlterationDataDecision MakingDefectDorsalElectrodesElectroencephalographyEquilibriumExhibitsFailureFunctional disorderGeneticHumanImpaired cognitionImpairmentIndividualLearningLinkMeasuresMediatingMonkeysN-Methyl-D-Aspartate ReceptorsNeural Network SimulationNeuronal PlasticityNeuronsNoiseParietalParietal LobePatientsPatternPerceptionPerceptual DisordersPersonsPharmacologyPlayPrefrontal CortexProcessProductionPsychosesRegimenRoleSchizophreniaSeriesSignal TransductionSiliconesStructureSymptomsSynapsesSynaptic ReceptorsSynaptic TransmissionTechniquesTestingThinkingTimeTrainingTranslatingbasebehavioral responsecognitive trainingearly psychosisimprovedindexingneurophysiologyneurotransmissionnonhuman primatepsychosis riskrelating to nervous system
项目摘要
PROJECT SUMMARY: PROJECT 1
The purpose of PROJECT 1 is to use nonhuman primates to examine prefrontal local circuit and distributed
network impairments associated with state representation dysfunctions of relevance to individuals with
psychosis. PROJECT 1 will relate synaptically mediated functional interactions between neurons in prefrontal
networks to computations that support state representation processes. In Aim 1, we will quantify functional
neural interactions by measuring temporal correlations in the timing of action potentials (‘spikes’) imposed by
synaptic interactions between the neurons. In Aim 2, we will disrupt those interactions by pharmacologically
blocking NMDA receptors (NMDAR), which induces a period of transient cognitive impairment during which
monkeys commit similar patterns of behavioral errors during the DPX decision-making task as do people with
schizophrenia. We will record neural activity in prefrontal cortex and anatomically connected brain areas
(posterior parietal cortex and the dorsal striatum) concurrently during the period of cognitive impairment, while
monkeys perform the DPX and Bandit tasks, which allow us to index state estimation, state learning, and state
stability processes. We will discover how reducing NMDAR synaptic transmission alters functional interactions
between neurons in prefrontal networks, leading to computational failures in state representation processes.
To provide a bridge to neural signals that we can record in humans, we will record neural signals that reflect
brain activity at the microscale (single neuron action potentials), mesoscale (local field potentials within a
cortical area) and macroscale (local field potentials and EEG across cortical areas) from prefrontal cortex and
connected structures simultaneously. We will use causal discovery analysis to identify the parameters that can
be found with more limited neurophysiological techniques available in humans (for PROJECTS 3 and 4). As
PROJECT 4 identifies specific cognitive training regimens that improve state estimation and state stability in
individuals with early psychosis, PROJECT 1 will back-translate these paradigms to monkeys to identify
training-induced changes in attractor network parameters at the neurophysiological (micro-, meso- and macro-
circuit) levels.
项目总结:项目1
项目成果
期刊论文数量(0)
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MATTHEW V CHAFEE其他文献
MATTHEW V CHAFEE的其他文献
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{{ truncateString('MATTHEW V CHAFEE', 18)}}的其他基金
Spike Timing Defects and State Representation Impairments in Nonhuman Primates
非人类灵长类动物的尖峰计时缺陷和状态表征损伤
- 批准号:
10597068 - 财政年份:2020
- 资助金额:
$ 35.54万 - 项目类别:
Circuit and synaptic basis of cognitive control in monkey prefrontal cortex
猴前额皮质认知控制的回路和突触基础
- 批准号:
9263766 - 财政年份:2015
- 资助金额:
$ 35.54万 - 项目类别:
Circuit and synaptic basis of cognitive control in monkey prefrontal cortex
猴前额皮质认知控制的回路和突触基础
- 批准号:
8943506 - 财政年份:2015
- 资助金额:
$ 35.54万 - 项目类别:
Prefrontal network dynamics and top-down control of spatial representation
前额网络动力学和空间表征的自上而下控制
- 批准号:
8234208 - 财政年份:2009
- 资助金额:
$ 35.54万 - 项目类别:
Prefrontal network dynamics and top-down control of spatial representation
前额网络动力学和空间表征的自上而下控制
- 批准号:
7877708 - 财政年份:2009
- 资助金额:
$ 35.54万 - 项目类别:
Prefrontal network dynamics and top-down control of spatial representation
前额网络动力学和空间表征的自上而下控制
- 批准号:
8437283 - 财政年份:2009
- 资助金额:
$ 35.54万 - 项目类别:
Prefrontal network dynamics and top-down control of spatial representation
前额网络动力学和空间表征的自上而下控制
- 批准号:
8035911 - 财政年份:2009
- 资助金额:
$ 35.54万 - 项目类别:
Prefrontal network dynamics and top-down control of spatial representation
前额网络动力学和空间表征的自上而下控制
- 批准号:
7730744 - 财政年份:2009
- 资助金额:
$ 35.54万 - 项目类别:
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