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Prefrontal network dynamics and top-down control of spatial representation

前额网络动力学和空间表征的自上而下控制

基本信息

批准号：
8234208
负责人：
MATTHEW V CHAFEE
金额：
$ 27.74万
依托单位：
UNIVERSITY OF MINNESOTA
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-06-20 至 2014-02-28
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8234208
关键词：
Area Behavioral Behavioral Paradigm Biological Neural Networks Brain Categories Cerebral cortex Code Cognition Cognitive Event Experimental Designs Goals Grouping Human Individual Joints Knowledge Left Measurable Measures Mediating Monkeys Morphologic artifacts Nature Network-based Neurons Output Parietal Parietal Lobe Pattern Performance Persons Physiological Physiological Processes Play Positioning Attribute Prefrontal Cortex Process Property Recruitment Activity Relative (related person)Research Role Schizophrenia Sensory Process Signal Transduction Stimulus Stroke System Testing Time Training Ursidae Family Visual Work abstracting base cognitive function design executive function flexibility human disease member neuromechanism nonhuman primate relating to nervous system research study response spatial relationship success visual receptive field visual stimulus

项目摘要

Abstract The human brain processes sensory input flexibly to extract the most useful information and generate the most advantageous response given current behavioral strategies and goals. Computational flexibility of this type is often referred to as executive control, particularly when it involves the brain selecting to implement one cognitive process over another in order to determine the best course of action within a given context. We have a limited understanding of how executive control, as such, is mediated by physiological events in cortical neurons. To increase our knowledge of the cellular basis of executive control, I propose to simultaneously record the electrical activity of ensembles of 20-30 individually isolated neurons in prefrontal cortex (area 46) and in posterior parietal cortex (area 7a) of monkeys as they perform a task requiring them to exert executive control over spatial cognition. Specifically, monkeys will assign visual stimuli to alternative spatial categories according to a variable grouping criterion (rule) that we instruct and change on a trial-by-trial basis. In this task, we present a line that serves as a category boundary, and define spatial categories as groups of spatial positions that bear the same spatial relationship to the line - such that, for example, all points to the left of the line comprise one category, and all points to the right another. By shifting and rotating the boundary, we require the brain to flexibly reassign a fixed set of spatial positions to alternative spatial categories in a rule- dependent manner, and this requires the brain to exert executive control over spatial categorization as a cognitive and physiological process. Our objective is to discover how executive control over spatial categorization is implemented at a cellular level, by measuring rule-dependent changes in distributed neural representations of the spatial category to which the brain has assigned a stimulus under a given rule. We will test the hypothesis that rule-dependent changes in category representation will emerge first and be strongest in prefrontal cortex. This will support our hypothesis that prefrontal cortex sits above parietal cortex in a hierarchy of areas mediating executive control over cognitive processing in distributed cortical systems, and provide some of the first detail about the neural mechanisms by which this control is implemented at a cellular level.

摘要